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This book reviews biochemistry, molecular biology and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. Surveys cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts.

C-type Lectin Receptors in Antifungal Immunity.- Immune recognition of pathogen-derived glycolipids through Mincle.- CLEC5A: A promiscuous pattern recognition receptor to microbes and beyond.- Collectins: Innate immune pattern recognition molecules.- Insect C-type lectins in microbial infections.- Galectins in Host Defense against Microbial Infections.- Galectins in Host-Pathogen Interactions: Structural, Functional and Evolutionary Aspects.- Siglecs at the Host-Pathogen Interface.- Siglecs that associate with DAP12.

This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins.

This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems.

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment.

1. Novel techniques to study the bone-tumor microenvironment2. An emerging model for cancer development from a tumor microenvironment perspective in mice and humans3. Effects of Exercise on the Tumour Microenvironment4. Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment5. Multimodal molecular imaging of the tumour microenvironment6. Necrosis in the tumor microenvironment and its role in cancer recurrence7. The Multifaceted Effects of Autophagy on the Tumor Microenvironment8. The Sociobiology of Brain Tumors9. Tumor microenvironment conditioning by abortive lytic replication of oncogenic ╬│-herpesviruses10. The microbiome as a component of the tumor microenvironmentIndex

Chapter 1: The intestinal tumour microenvironmentChapter 2: Gastric Tumor MicroenvironmentChapter 3: Parathyroid tumor microenvironmentChapter 4: Microenvironment in Cardiac Tumor Development: What Lies Beyond the Event Horizon?Chapter 5: The roles of bone marrow-resident cells as a microenvironment for bone metastasisChapter 6: Adipose tumor microenvironmentChapter 7: Appendix Tumor MicroenvironmentChapter 8: Spinal cord tumor microenvironmentChapter 9: Cancer stem cell niche and immune-active tumor microenvironment in testicular germ cell tumorsChapter 10: Tumor microenvironment in skin carcinogenesisIndex 

In addition, laboratory and clinical studies have confirmed that the chemical components of Ganoderma, such as Ganoderma lucidum polysaccharide peptides and triterpenes isolated from the fruiting body of Ganoderma lucidum, produce diverse pharmacological effects.

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment.

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development.

1. Notch signalling and embryology: an introduction2. Notch signaling and embryonic development: an ancient friend, revisited3. The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development4. Epigenetic regulation of Notch signaling during Drosophila development5. Regulation of proneural wave propagation through a combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion6. A nucleolar protein, Nepro, is essential for the maintenance of early neural stem cells and preimplantation embryos7. The role of Notch signaling in leg development in Drosophila melanogaster8. Notch pathway and inherited diseases: challenge and promiseIndex

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment.

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment.

This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer.

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic.

This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease.The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges.The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued.Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.

In this book, renowned scientists describe how cholesterol interacts with various proteins. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.

Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology - Novel Concepts, Pericyte Biology in Disease presents a comprehensive update on the latest information and most novel functions attributed to pericytes.

Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably ¿primitive¿) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the ¿natural¿ immunity brought about by immune phagocytes.The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.

There are several types of damage that can be found in the male gamete. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods.

The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders.

Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies.

Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies.

Good health and medical care in childhood and adolescence are essential for the ability to neutralize health threats later in life and to extend longevity.

The chapters in this topical volume of Advances in Microbiology, Infectious Diseases and Public Health present exciting, insightful observations on emerging viral infections like influenza, Middle East respiratory syndrome, or mosquito-transmitted diseases, as well as the potential of social media in preventing and fighting infectious diseases.

It also discusses metastatic renal cell carcinoma - a global scourge with an extremely poor long-term survival prognosis, the course and sequelae of renal cell carcinoma, as well as advances in targeted molecular therapy with sunitinib, a receptor tyrosine kinase inhibitor.

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2018 Impact Factor: 2.126.

There few books that currently cover the field of emerging sample treatments in proteomics, this new volume will be the first to cover all emerging and existing studies.