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This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection.

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies.

This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD).

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development.

Although some chitin-containing organisms are a threat to human health, food safety and agricultural production, non-chitin containing organisms like humans, mammals and plants have an innate immune response to these hazardous organisms.

This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation.

This book focuses on issues in clinical practice and research that are of general interest. Further, the book enhances the current body of knowledge on diagnostics and patient treatment and offers valuable new perspectives on practical clinical issues.

This book shows the huge impact the gut microbiota has on the gastrointestinal health of humans with a particular focus on children.

Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Expertsalso discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Respiratory allergy is constantly encountered and is sharply on the rise, particularly in the two most vulnerable age-groups: young children and seniors.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series ''Cell Biology and Translational Medicine (CBTMED)'' as part of SpringerNatureΓÇÖs longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fifth volume of a continuing series.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models.

This second edition emphasizes the environmental impact on reproduction, with updated chapters throughout as well as complete new chapters on species such as sharks and rays.

Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma.

This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ. Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues.

With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers.

When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity - Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.With a goal to accelerate advances by timely information exchange, this new book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series is launched. Emerging areas of regenerative medicine and translational aspects of stem cells will be covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the first volume of a continuing series.

This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.

a chapter on regulation of nephrin phosphorylation in diabetes and chronic kidney injury and a chapter on The Structure-Forming Juncture in oxidative protein folding and the events in the ER.

This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases.

Nearly 30 years ago, a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders University, in Adelaide, Australia to discuss the advances and future of their research. It was a friendly and stimulating meeting, attended by most of the major players, in what was to become the discipline of 'Neurogastroenterology'.In 2014, the main Australasian Neuroscience Society meeting was held in Adelaide, Australia, providing the perfect opportunity to recreate a follow-up ENS meeting. As such, the 'ENS II 2014 meeting' aimed to identify how far the field of enteric neuroscience had developed, where the future was heading, and what technological advances had been made to address current and future unresolved questions. 30 speakers from around the world were invited to give talks and revisit the original expectations, the advances made since, and the future directions of ENS research. These discussions included three generations of investigators from 7 different countries. This publication represents the majority of proceedings from the 'The Enteric Nervous System II 2014' conference, which was held on February 1st - 2nd 2014 at the National Wine Centre of Australia, Adelaide. This meeting was an Official satellite meeting of the 34th Annual Meeting of Australasian Neuroscience Society, which was also held in Adelaide. The 20 contributions contained within this submission are from international researchers in the field of the ENS, who reviewed the advances made since the first meeting in the early 1980s and summarizes the present and future perspectives of neuro-gastroenterology. Some colleagues could not attend but did send greetings and their messages are included in these proceedings.

The BAR (Bin-Amphiphysin-Rvs) domain is a membrane lipid binding domain present in a wide variety of proteins, often proteins with a role in Rho-regulated signaling pathways.

This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown.These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammation, or the vulnerability of cancer patients to bacterial meningitis, the infection that remains underdiagnosed due to limited expression of symptoms. The book also covers other key topics, such as the psychological care of lung cancer patients; difficulties in the diagnosis of diffuse axonal injury in traumatic brain injury ΓÇô a disorder with a poor prognosis and high mortality rate; and the virological aspects of seasonal influenza epidemic outbreaks ΓÇô a perennial modern scourge. Further, it addresses recent developments in targeted drug delivery from titanium implants and a novel integrated thermal approach to rehabilitation of neurodegeneration-related disabilities. Featuring the latest interdisciplinary trends in biomedicine, this book connects research, theory and practice to help alleviate suffering caused by a variety of diseases.It is a resource for medical professionals, including academics, practitioners and all allied healthcare workers.

Guido N├║├▒ez-Mujica, Therese Kichuk and Cesar Carrasco-Lopez Data Analysis of Infection Rates Among Exposed Healthcare Workers Could Reveal Effective Prophylactics Against SARS-CoV-2Nihal ─░NANDIKLIO─₧LU, Tun├º AKKO├ç IMMUNE RESPONSES TO SARS-CoV, MERS-CoV AND SARS-CoV-2Mariusz Bral MD PhD, and A.M. James Shapiro MD PhD Normothermic Preservation of Liver - What does the Future Hold?Gregor Haring, Janja Zupan,  Tissues from Post-Mortem Donors as Alternative Sources of Stem Cells for Regenerative Medicine├û. Sezin SOMUNCU, H. Matthew BERNS, J. Guillermo SANCHEZ New Pioneers of Optogenetics in NeuroscienceP─▒nar Ercal, Gorke Gurel Pekozer A Current Overview of Scaffold-Based Bone Regeneration Strategies with Dental Stem CellsMahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini, Mohamadreza Baghaban Eslaminejad The Importance of Stem Cell Senescence in Regenerative MedicineZehra Narli Ozdemir Sinem Civriz Bozdag Hematological Malignancies and FertilityC. Fornaguera, C. Castells, S. Borr├│s Unraveling polymeric nanoparticles cell uptake pathways: two decades working to understand nanoparticles journey to improve gene therapyMotahareh Sheikh Hosseini; Peyvand Parhizkar Roudsari; Kambiz Gilany; Parisa Goodarzi; Moloud Payab;  Akram Tayanloo-Beik; Bagher Larijani; Babak Arjmand Cellular Dust as a Novel Hope for Regenerative Cancer Medicine

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.