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The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Annual Reports in Medicinal Chemistry series

Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.Provides an overview of the status of some of the current novel compounds in development as well as new emerging treatment options targeting novel mechanisms of actionIdentification of hits from phenotypic whole cell screening, followed by target identificationStrategies aimed at improving the efficacy of existing clinically used anti-TB drugs by taking advantage inhibitors of mycobacterial transcriptional regulators to boost the anti-tubercular activity, and circumvent acquired-resistance

Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Annual Reports in Medicinal Chemistry seriesIncludes the latest information on Medicinal Approaches to Malaria and Other Tropical Diseases

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Focuses on providing critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences. Sections I-IV in this work are disease orientated and generally report on specific medicinal agents. Sections V and VI emphasize important topics in medicinal chemistry, biology, and drug design.

Provides critical reviews of important topics in medicinal chemistry together with an emphasis on topics in the biological sciences. This title highlights major developments in medicinal chemistry.

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies.

"Annual Reports in Medicinal Chemistry" provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.