Bøker i Computational Neuroscience Series-serien

A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition.This textbook presents a wide range of subjects in neuroscience from a computational perspective. It offers a comprehensive, integrated introduction to core topics, using computational tools to trace a path from neurons and circuits to behavior and cognition. Moreover, the chapters show how computational neuroscience—methods for modeling the causal interactions underlying neural systems—complements empirical research in advancing the understanding of brain and behavior. The chapters—all by leaders in the field, and carefully integrated by the editors—cover such subjects as action and motor control; neuroplasticity, neuromodulation, and reinforcement learning; vision; and language—the core of human cognition.The book can be used for advanced undergraduate or graduate level courses. It presents all necessary background in neuroscience beyond basic facts about neurons and synapses and general ideas about the structure and function of the human brain. Students should be familiar with differential equations and probability theory, and be able to pick up the basics of programming in MATLAB and/or Python. Slides, exercises, and other ancillary materials are freely available online, and many of the models described in the chapters are documented in the brain operation database, BODB (which is also described in a book chapter).ContributorsMichael A. Arbib, Joseph Ayers, James Bednar, Andrej Bicanski, James J. Bonaiuto, Nicolas Brunel, Jean-Marie Cabelguen, Carmen Canavier, Angelo Cangelosi, Richard P. Cooper, Carlos R. Cortes, Nathaniel Daw, Paul Dean, Peter Ford Dominey, Pierre Enel, Jean-Marc Fellous, Stefano Fusi, Wulfram Gerstner, Frank Grasso, Jacqueline A. Griego, Ziad M. Hafed, Michael E. Hasselmo, Auke Ijspeert, Stephanie Jones, Daniel Kersten, Jeremie Knuesel, Owen Lewis, William W. Lytton, Tomaso Poggio, John Porrill, Tony J. Prescott, John Rinzel, Edmund Rolls, Jonathan Rubin, Nicolas Schweighofer, Mohamed A. Sherif, Malle A. Tagamets, Paul F. M. J. Verschure, Nathan Vierling-Claasen, Xiao-Jing Wang, Christopher Williams, Ransom Winder, Alan L. Yuille

Churchland and Sejnowski address the foundational ideas of the emerging field of computational neuroscience, examine a diverse range of neural network models, and consider future directions of the field.

A textbook for students with limited background in mathematics and computer coding, emphasizing computer tutorials that guide readers in producing models of neural behavior.This introductory text teaches students to understand, simulate, and analyze the complex behaviors of individual neurons and brain circuits. It is built around computer tutorials that guide students in producing models of neural behavior, with the associated Matlab code freely available online. From these models students learn how individual neurons function and how, when connected, neurons cooperate in a circuit. The book demonstrates through simulated models how oscillations, multistability, post-stimulus rebounds, and chaos can arise within either single neurons or circuits, and it explores their roles in the brain. The book first presents essential background in neuroscience, physics, mathematics, and Matlab, with explanations illustrated by many example problems. Subsequent chapters cover the neuron and spike production; single spike trains and the underlying cognitive processes; conductance-based models; the simulation of synaptic connections; firing-rate models of large-scale circuit operation; dynamical systems and their components; synaptic plasticity; and techniques for analysis of neuron population datasets, including principal components analysis, hidden Markov modeling, and Bayesian decoding. Accessible to undergraduates in life sciences with limited background in mathematics and computer coding, the book can be used in a "flipped” or "inverted” teaching approach, with class time devoted to hands-on work on the computer tutorials. It can also be a resource for graduate students in the life sciences who wish to gain computing skills and a deeper knowledge of neural function and neural circuits.

Using experimental and theoretical findings from cellular biophysics, this book explains the computational functions of single neurons. The topics include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; and chemical and electrical synapses and how to treat them from a computational point of view.

This volume, on unsupervised learning algorithms, focuses on neural network learning algorithms that do not require an explicit teacher. The goal of unsupervised learning is to extract an efficient internal representation of the statistical structure implicit in the inputs. These algorithms provide insights into the development of the cerebral cortex and implicit learning in humans. They are also of interest to engineers working in areas such as computer vision and speech recognition who seek efficient representations of raw input data.

An introduction to the computational biology of reaching and pointing, with an emphasis on motor learning.

A mathematical framework that describes learning of invariant representations in the ventral stream, offering both theoretical development and applications.

A practical guide to neural data analysis techniques that presents sample datasets and hands-on methods for analyzing the data. As neural data becomes increasingly complex, neuroscientists now require skills in computer programming, statistics, and data analysis. This book teaches practical neural data analysis techniques by presenting example datasets and developing techniques and tools for analyzing them. Each chapter begins with a specific example of neural data, which motivates mathematical and statistical analysis methods that are then applied to the data. This practical, hands-on approach is unique among data analysis textbooks and guides, and equips the reader with the tools necessary for real-world neural data analysis.The book begins with an introduction to MATLAB, the most common programming platform in neuroscience, which is used in the book. (Readers familiar with MATLAB can skip this chapter and might decide to focus on data type or method type.) The book goes on to cover neural field data and spike train data, spectral analysis, generalized linear models, coherence, and cross-frequency coupling. Each chapter offers a stand-alone case study that can be used separately as part of a targeted investigation. The book includes some mathematical discussion but does not focus on mathematical or statistical theory, emphasizing the practical instead. References are included for readers who want to explore the theoretical more deeply. The data and accompanying MATLAB code are freely available on the authors' website. The book can be used for upper-level undergraduate or graduate courses or as a professional reference.A version of this textbook with all of the examples in Python is available on the MIT Press website.