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In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer¿s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. This volume provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

Neurobiology of TRP channels will review the current knowledge on how these important proteins participate in physiological and pathophysiological processes. The book is includes chapters by experts on the role of TRP channels in the peripheral and central nervous system.

Neurobiology of TRP channels will review the current knowledge on how these important proteins participate in physiological and pathophysiological processes. The book is includes chapters by experts on the role of TRP channels in the peripheral and central nervous system.

An ideal introduction to statistical neurocomputing, this book examines current statistical methods for solving emerging problems in neuroscience. These methods have been applied to data involving multichannel neural spike train, spike sorting, blind source separation, functional and effective neural connectivity, spatiotemporal modeling, and multimodal neuroimaging technique. It provides an overview of various methods being applied to specific research areas of neuroscience. The book emphasizes statistical principles and their software. It includes examples and experimental data so that readers can understand the principles and master the methods.

Integrating expert perspectives across disciplines, this book address knowledge gaps in the field of TBI. Topics include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more.

Exploring the role of the chemical senses in mediating intraspecific communication, this volume examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, cats, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of the different species.

Offers coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. This book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments.

Describes molecular, electrophysiological, engineering, genetic, behavioral, psychophysical, and imaging techniques that have been adapted to investigate the basic neuronal mechanisms underlying chemoreception. This book investigates various aspects of taste and olfaction.

Focusing on how increased understanding of brain function affects clinical neuroscience, this title explores the interface between neuroscience advances and clinical neuroscience advances by examining the hypotheses that drive this evolution. It reviews the relevant underpinnings of neurosurgical techniques, treatments, and conceptual approaches.

Offering a description of the techniques and theories employed in both basic and clinical research, this book delineates the mechanisms underlying neuronal damage induced by ischemia. It covers methods to elucidate the pathogenesis of ischemia, and technologies used in the design of specific strategies to protect neurons from further injury.

Offers a comprehensive description of the experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture control. This text demonstrates how spinal cord circuits operate under a variety conditions.

TRP channels have been shown to respond to a range of stimuli within and outside the cell. This book highlights progress in the elucidation of the in-vivo function of the various members of the TRP ion channel family, and examines research leading up to the development of novel pharmaceuticals for the treatment of cancer and heart disease.

Designed as an introduction to realistic modeling methods, this title focuses on methodological approaches, selecting appropriate methods, and identifying potential pitfalls. It provides various chapters that include theoretical foundations, parameters needed, appropriate software descriptions, evaluation of the model, and future directions.

Brings the contrasting views of the behavior-biology divide into focus to promote a concerted view of timing and time perception. This book describes the basic mathematical and psychological aspects of scalar timing theory and mode-control models of counting and timing. It also examines the roles of attention and memory in interval timing.

Covers developments in electrode design and analyses from ensembles. This work contains material that cover: multi-electrode array design, strategies for multi-electrode recording data analysis, chronic recordings, using multi-electrode recordings to build brain-machine interfaces, and explorations of future directions.

Bridges the gap between cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. This book covers procedures, methods, and equipment used in experiments, that, in many cases, combine multiple technical approaches.

Presents a study of apoptosis in neurobiology and its significance to the nervous system. This book describes various methods that are used in the study and evaluation of apoptosis. It is suitable for biomedical researchers.

With excerpts from international specialists in the field of neurobiology, this book presents state of the art research on the neurobiological aspects of depression. It discusses opioid and endocannabinoid systems and depression and explores other sources for depression provided by research in biochemistry, molecular biology, and genomics. Topics covered include genetic factors of depression; monoaminergic pathways and depression; serotonergic pathways and depression; melantonergic system, chronobiological rhythms, and depression; the significance of tachykinin mechanisms in depression; and the melatonergic system, chronobiological rhythms, and depression. This book serves as a reference for researchers in neuroscience and related fields, as well as graduate students.

It has become accepted in the neuroscience community that perception and performance are quintessentially multisensory by nature. Using the full palette of modern brain imaging and neuroscience methods, this volume details current understanding in the neural bases for these phenomena as studied across species, stages of development, and clinical statuses.Topics discussed include anatomy, neurophysiological bases and how multisensory stimuli can dramatically change the encoding processes for sensory information, combinatorial principles and modeling, development and plasticity, clinical manifestations, how perception and action are affected by altered sensory experience, and attention and spatial representations.

Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. This volume emphasizes cellular connections and surveys the most current findings on astrocyte activity. The book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. It examines the role of these connections and explains how their function can be manipulated and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain.

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, this title focuses on the many aspects of the research on drugs to treat Huntington's disease. It also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.

Focuses on critical concerns regarding dietary fat and its relation to obesity. This work presents scientific data on the many aspects of fat consumption including psychological, behavioral, genetic, and physiologic factors that contribute to its desirability, perception, intake and impact on human health.

Covers a range of topics from contemporary techniques in receptor research to fundamental interactions of the 5-HT receptors with the lipid bilayer to behavioral studies.

Provides an overview of the status of knowledge and research on olfaction. This book includes content from genetics to behavior and from nematodes to humans. It also contains chapters about the discoveries on odor coding from the olfactory epithelium to cortical centers and about neurogenesis in the olfactory epithelium and in the olfactory bulb.

Featuring contributions from leading experts, this book presents an overview of various approaches used to investigate the biologic mechanisms of drug addiction. It includes the behavioral strategies and characteristics of addiction as well as the mechanistic approaches to understanding the underlying neurobiology.

Presents a coherent summary of vagal afferent neuroscience obtained within the body's organ systems. This book contains chapters that deal with vagal nerves in the central nervous system, lungs, esophagus, heart, and gastrointestinal tract. It also covers critical aspects ranging from vagus nerves in the embryo to vagus nerves in the adult.

Neurosteroids play a critical role in the neurobiology and treatment of such disorders as schizophrenia, bipolar disorder, and depression. The field of neurosteroids is evolving from a large body of basic knowledge into key elements that are being translated into clinical therapeutics, biomarkers, and potentially laboratory tests for a host of neuropsychiatric disorders. This book provides a comprehensive overview of the most exciting, late-breaking data in the neurosteroid field today, contributed by a pioneering panel of experts in the field.