Bøker i Handbook of Clinical Neurology-serien

Interventional Neuroradiology, Volume 179, provides a basic outline of the field of interventional neuroradiology that is accessible to fellows, residents, clinicians and researchers in various disciplines, from diagnostic and interventional radiology to vascular neurology, general and vascular neurosurgery, and vascular biology. This volume offers a timely update to experienced clinical practitioners in a logical, easy-to-follow format. Content includes neurovascular anatomy, vascular biology, neurovascular physiology, vascular imaging, as well as sections on the diagnosis and therapeutic treatment of neurovascular disease. Explores the general scope of current clinical interventional neuroradiology, both for endovascular and percutaneous image-guided diagnosis and interventions in a variety of pathologiesDefines basic physiological principles (e.g., cerebral perfusion pressure, intracranial pressure, vasospasm, tissue osmolality) with reference to those most essential to the management of neurovascular diseasesDiscusses pathophysiology and the unique challenges of pediatric cerebrovascular diseases, as well as endovascular and surgical therapies

Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered.

Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable.

Neurological Channelopathies, Volume 203 begins with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations, but that also have potential for common treatment approaches, considering classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter considers Pathophysiological underpinnings - genetic or immunological; Clinical presentations; Diagnostic approach; and Treatment and management.In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological, and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the topics at hand.

Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable are also critically reviewed.Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also explored.

Migraine Biology, Diagnosis, and Co-Morbidities, Volume 198 covers a wide range of issues related to migraine. The epidemiology, global, and personal impacts of migraine are covered, including topics on the pathophysiology of migraine and migraine aura, the pathophysiology of the associated symptoms of photophobia and phonophobia, and the genetics of migraine. The classification and diagnostic criteria of common and uncommon subtypes of migraine are also explored in detail, including childhood variants. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also covered. Finally, the important comorbidities of migraine such as anxiety, depression and other forms of chronic pain are discussed, along with the current state and future directions of migraine research and management.

Interoperative Monitoring, Volume 186 provides a concise overview of advances in interoperative monitoring targeted for clinical neurologists. It identifies techniques (EEG, ECoG, EMG, etc.), optimal anesthesia for use, safety issues to be considered, and then discusses advances as they relate to intracranial, spinal, peripheral nerve and vascular surgery. Best practices and case studies are included for all chapters as well as surgical microscope views, illustrations, and medical imaging.

Neuropalliative Care, Part Two, Volume 191 covers a type of care that is given when there is no cure for the neurological disorder and the patient is in distress. It provides a scholarly background of neuropalliative care, from historic underpinnings to its practice in various geographical regions, along with best practices for specific neurological disorders. It covers the work of multi or interdisciplinary teams whose care is intended to make the patient as comfortable as possible and includes partners and families in treatment plans.

Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within.This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases.

Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summarize the basic mechanisms of neuroplasticity, focus on neuroplasticity in movement disorders, discuss brain oscillations in neurological disorders, segue into plasticity in neurorehabilitation, and cover issues of inflammation and autoimmunity in neuroplasticity. The book concludes with a section on neuroplasticity and psychiatric disorders.

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson¿s, Alzheimer¿s and other neurological disorders relate to the hypothalamus.

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson¿s, Alzheimer¿s and other neurological disorders relate to the hypothalamus.

The neurology of sex and bladder disorders requires specialized knowledge and represents a challenge for clinical neurologists focused on the neurological condition. This title provides tutorial reference to the science, diagnosis and treatment of sex and bladder disorders from a neurologic perspective.

The Handbook of Clinical Neurology volumes on Traumatic Brain Injury (TBI) provide the reader with an updated review of emerging approaches to TBI research, clinical management and patient rehabilitation. Chapters in Part II offer coverage of clinical sequelae and long-term outcome, brain plasticity and long-term risks, and clinical trials.  Contemporary investigations on blast injury and chronic traumatic encephalopathy are presented, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI. Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including complications to movement, mood, cognition and moreExplores cellular/molecular and genetic factors contributing to plasticity Presents up-to-date expert recommendation for clinical trials and issues related to effective rehabilitationNew findings are included on the long-term effects of traumatic brain injury that may impact aging and lead to dementia

The neuroscience of the human auditory system is a dynamic area of basic research with dramatic clinical application. This volume provides a comprehensive and focused reference on the neuroscience of hearing and the associated neurological diagnosis and treatment of auditory disorders.

The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI. Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injuryExplores cellular and molecular mechanisms as well as genetic predictors of outcomeOffers coverage of various diagnostic tools - CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and moreState-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care

Suitable for clinicians and researchers, this reference summarizes clinical features and management of many neurological manifestations of sleep disorders. It also offers the research, information, and laboratory techniques on topics such as sleep-wake-dependent genes, the role of sleep duration in mortality and morbidity, and more.

Offers information on the technological advancements that have occurred in neuroimaging, thus furthering diagnostic and treatment modalities. This title includes philosophical and ethical implications involving the relationship between clinicians and patients with impaired levels of consciousness.

Provides an understanding of developments and advancements in the study of ataxic disorders. This book gives clinicians a reference for the management of the many etiologies and neurological manifestations of ataxic disorders.

Offers an account of the human hypothalamus. The human hypothalamus is a complex structure and consists of a large number of very different functional units (nuclei) that are not included in the standard neuropathological investigation of the human brain.

Sports Neurology is designed to be a comprehensive overview of neurology within the context of sports medicine. This definitive text addresses the history of sports neurology, including its unique role within sports medicine, and provides a detailed assessment of central and peripheral nervous system injuries and illnesses in athletes. Sports Neurology is a critical companion for all sports medicine clinicians and for neurologists who manage athletes. Provides an introduction and overview of concussion in sport, discussing the epidemiology, biomechanics and pathophysiology of concussion, as well as considerations for sideline evaluation and emergency room diagnosis and managementExplores the long-term consequences of concussion and repetitive head impacts and the relationship with neurodegenerationOffers an overview of mild, moderate and severe brain injury classification; compares moderate and severe traumatic brain injury within the context of civilian, military and sports circumstancesDescribes key issues for the evaluation and treatment of cervical spinal cord injuries, peripheral nerve injuries, and sports-related painProvides an overview of neuroepidemiology and the importance of obtaining meaningful sport-related neuroepidemiologic data that will ultimately provide the foundation for making data-driven decisions for central and peripheral nervous system injuries in sport

Neuro-Otology: a volume in the Handbook of Clinical Neurology series,áprovides a comprehensive translational reference on the disorders of the peripheral and central vestibular system. The volume is aimed at serving clinical neurologists who wish to know the most current established information related to dizziness and disequilibrium from a clinical, yet scholarly, perspective. This handbook sets the new standard for comprehensive multi-authored textbooks in the field of neuro-otology. The volume is divided into three sections, including basic aspects, diagnostic and therapeutic management, and neuro-otologic disorders. Internationally acclaimed chapter authors represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience. The Basic Aspects section is brief and covers the material in sufficient depth necessary for understanding later translational and clinical material. The Diagnostic and Therapeutic Management section covers all of the essential topics in the evaluation and treatment of patients with dizziness and disequilibrium. The section on Neuro-otologic Disorders is the largest portion of the volume and addresses every major diagnostic category in the field.Synthesizes widely dispersed information on the anatomy and physiology of neuro-otologic conditions into one comprehensive resourceFeatures input from renowned international authors in basic science, otology, and neurosciencePresents the latest assessment of the techniques needed to diagnose and treat patients with dizziness, vertigo, and imbalanceProvides the reader with an updated, in-depth review of the clinically relevant science and the clinical approach to those disorders of the peripheral and central vestibular system