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This handbook collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. It provides practical details on animal ethics, models, and handling to assist researchers in planning and executing their small animal imaging studies. The book also explains how to measure and quantify images and explores a broad spectrum of disease types and disease sites where small animal imaging and therapy are currently applied, including cardiovascular disease and intracellular targets.

The first text to focus solely on quality and safety in radiotherapy, this work encompasses not only traditional technically oriented quality assurance activities, but also general approaches regarding quality and safety. It includes contributions from experts both inside and outside the field to discuss both the processes and the people deliver

About ten years after the first edition comes this second edition of Monte Carlo Techniques in Radiation Therapy: Introduction, source modelling and patient dose calculations, thoroughly updated and extended with the latest topics, edited by Frank Verhaegen and Joao Seco.

Thoroughly updated throughout, this second edition of Monte Carlo Techniques in Radiation Therapy: Applications to Dosimetry, Imaging, Preclinical radiotherapy, edited by Joao Seco and Frank Verhaegen, explores the use of Monte Carlo methods for modelling various features of international and external radiation sources.

This book provides a complete summary of principles, instrumentation, methods, and clinical applications of 3D dosimetry in modern radiation therapy treatment. It is an essential guide for those involved in design and implementation of treatment technology and applications in advanced radiation therapy.

This book provides a detailed treatment of online interventional techniques for motion compensation radiotherapy. It explains how adaptive motion intervention is imaging-intensive and relies on near real-time image acquisition and processing. With a focus on the strategy of online motion compensation, the book discusses necessary motion detection methodology, repositioning methodology, and how to interpret and respond to target movement data in real time. It covers methods of detection and correction and then offers examples. It also gives attention to the distinct problems in dose planning and delivery posed by each adaptation technology.

This book provides a complete, introductory overview of this growing field and its applications in medical imaging, utilizing worked examples and exercises to demystify statistics for readers of any background. It covers discussion of study design basics and use of the techniques in imaging system optimization, among other topics.

This first dedicated overview for beam¿s eye view (BEV) covers instrumentation, methods, and clinical use of this exciting technology, which enables real-time anatomical imaging. It highlights how the information collected is used in the clinic for treatment verification, adaptive radiotherapy, and in-treatment interventions.

Exposed to ionizing radiation from medical imaging technology has increased dramatically in recent years, with annual X-ray and nuclear medicine studies numbering over two billion. This book provides a focused treatment of key aspects of dose, benefit, and risk in medical imaging and how to best apply this information for informed decision making to improve patient outcomes.

This book on radiochromic film covers the basic principles with a focus on the latest methods and applications in radiation dosimetry. It reflects advances in digital imaging and scanning equipment and modern uses of radiochromic films in diagnostic x-rays, brachytherapy, radiosurgery, and other emerging techniques.

This book provides a complete summary of principles, instrumentation, methods, and clinical applications of 3D dosimetry in modern radiation therapy treatment. It is an essential guide for those involved in design and implementation of treatment technology and applications in advanced radiation therapy.

This text provides coverage of PET and SPECT instrumentation and multimodality imaging. It takes an integrative approach, bridging the researcher and clinician¿s perspectives. It begins with an introduction to basic physics of PET and SPECT, followed by a section on detector technology. It addresses various aspects of producing quantitative images, such as techniques for image reconstruction, corrections to the data to produce quantitative images, and dynamic imaging. It also discusses instrumentation for multimodality imaging and technologies used in pre-clinical imaging using PET and SPECT.

This comprehensive book provides a detailed introduction to plastic scintillation dosimetry and its use in the field of radiation dosimetry. Comprised of chapters authored by leading experts in the medical physics community, the text discusses a broad range of state-of-the-art technical implementations, from point source dosimetry scaling to 3D-volumetric and 4D-scintillation dosimetry. It addresses a wide scope of clinical applications, from machine quality assurance to small-field and in vivo dosimetry. It also examines related optical techniques, such as optically stimulated luminescence (OSL) or ¿erenkov luminescence.

Due to improvements in image quality and the reduced cost of advanced features, ultrasound imaging is playing a greater role in the diagnosis and image-guided intervention of a wide range of diseases. Designed for individuals working on diagnostic and therapeutic applications, this book highlights the latest advances in using ultrasound imaging in image-guided interventions and ultrasound-based therapy. It presents current and emerging techniques, identifies trends in the use of ultrasound imaging, and addresses technical and computational problems that need to be solved.

This book gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. Basic principles are covered early on, and clinical applications become the focus thereafter. A final section introduces emerging models for cancer prevention and detection.

Detailing multi-modality image co-registration and radiobiology, this book discusses state-of-the-art strategies for patient simulation and immobilization, treatment planning, and dose calculation algorithms in stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT). It presents a comprehensive treatment of the field¿s history, major technological developments, clinical status, and practical considerations. The three main sections of the book cover delivery systems, precision patient positioning and immobilization, and treatment planning and dosimetry. The final section gives an overview of clinical outcomes and future directions for the field.

This cutting-edge book presents a comprehensive overview of tomosynthesis, a new quasi-three-dimensional x-ray imaging technique that provides improved visualization of complex anatomic structures. The text covers technical aspects and clinical applications and offers detailed discussions of system design and image reconstruction strategies. It provides readers with an in-depth understanding of the process of image formation and the practical tools necessary to tailor their tomosynthesis systems for new clinical applications.

Radioembolization is now the preferred treatment for both primary and secondary liver cancer. This handbook addresses the radiation biology, physics, nuclear medicine, and imaging for radioembolization using Yttrium-90 (90Y) microspheres, in addition to discussing aspects related to interventional radiology. The contents reflect new on-label hepatic treatment indications, both in the US and worldwide, as well as dose-response relationships associated with radioembolization and the utility of adjuvant radioembolization and systemic chemotherapy.

This book provides a comprehensive overview of computational methods used in radiation oncology and imaging physics, addressing clinical and research applications. It reflects the way in which technology has revolutionized these fields, for example showing how highly accurate model-based dose calculation engines are derived from transport theory, and how optimization tools enable delivery of highly conformal dose distributions, and how image processing, registration, and reconstruction tools are driving towards adaptive treatment planning. Readers will gain the skillset needed to adapt general mathematical techniques to real problems encountered in today's practice.