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Written by the pioneers of the sildenafil (Viagra) phosphodiesterase inhibitor drug, this timely reference discusses emerging applications of novel PDE inhibitors in a variety of disease fields with contributions from major pharmaceutical companies.

A comprehensive review of small and large open data sources relevant for rational drug design, covering small molecules, drug targets, ligand design, and many more drug-related aspects.

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

Well-documented case studies from recent drug development projects highlight the current and future importance of natural products as drug precursors, including much valuable practical knowledge for medicinal chemists working in or entering the field.

The first overview of mass spectrometry-based pharmaceutical analysis, this reference is the key to high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. Contains contributions from leading pharma companies and pharmaceutical research institutions.

This practice-oriented handbook highlights all issues relating to chirality of pharmaceuticals, from challenges in the synthesis of these complex molecules to analytical techniques to aspects of pharmacology and drug development. It is highly useful for every medicinal chemist involved in small molecule drug development.

Highlights the critical role of targeted drug delivery for unmet medical needs, by describing a wide range of different approaches for targeting small molecule as well as peptide and macromolecular drugs.

A timely and topical survey of modern simulation tools and their applications in realΓÇôlife drug discovery, allowing for better and quicker results in structureΓÇôbased drug design. The first part of this practical guide for industry professionals describes common tools used in the biomolecular simulation of drugs and their targets. A critical analysis of the accuracy of the predictions, the integration of modeling with other experimental data combined with numerous case studies from different therapeutic fields enable users to quickly adopt these new methods for their current projects. The second part then shows how these tools can be applied to drug discovery and development projects. Modeling experts from the pharmaceutical industry and from leading academic institutions present realΓÇôlife examples for important target classes such as GPCRs, kinases and amyloids as well as for common challenges in structureΓÇôbased drug discovery. With its inclusion of novel methods and strategies for the modeling of drugΓÇôtarget interactions in the framework of realΓÇôlife drug discovery and development, this applicationΓÇôoriented reference is tailorΓÇômade for medicinal chemists and those working in the pharmaceutical industry.

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology.

The secret of success in drug discovery written by the pioneers in the field with unrivaled experience in fragment-based methods. In this handbook, the first-hand knowledge imparted by the world's leading experts provides a comprehensive overview of current methods and applications of fragment-based discovery.

The complete picture of methods and strategies in industrial and academic lead finding and optimization, covering standard as well as novel approaches and highlighting their strengths and weaknesses. Includes several case studies of recent successful lead generation projects.

A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors?noted experts on the topic?examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: * Provides a guide for the effective development of solid drug forms *' Compares different characterization methods for solid state APIs * Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs * Includes information on automation, process control, and machine learning as an integral part of the development and production workflows * Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.

Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy.

A concise introduction to the parameters and processes governing the absorption, distribution and retention of drug compounds in the body, now expanded to cover prodrugs, antitumor drugs and predictive approaches.

Key content for every medicinal chemist: The understanding of ligand-target interactions is the basic skill that every medicinal chemist needs.

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design.

This practical referene for drug developers addresses the most common antitarget-related side effects, including hepatic, cardiovascular, kinase- and GPCR-mediated toxicity. Current strategies how to manage side effects as well as several case studies are included.

Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models. This title also presents a survey of the advances in the synthesis, separation and analysis of drugs. It also contains a special section devoted to molecular genetics methods.

Combinatorial chemistry is a revolutionary method, which allows you to synthesize millions of compounds within a few steps and in a very short amount of time. Millions of products, e.g. potential drugs, can be analyzed in one go, so that you know very fast if one or a few substances in your product mixture show biological activity.

By addressing both drug efficiency and drug safety, this modern practical reference shows how each aspect shapes the key decisions for assessing the risk/benefit ratio of any novel compound during the early drug development stages, using both in vitro and in silico methods.

Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists and virologists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronavirus-2 causing the present pandemic. 'New Drug Development for Known and Emerging Viruses' describes the discovery and development process of antiviral agents for different species of viruses and their targets based on the experiences from seven human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HCMV, and HSV). It covers the properties and potential of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. * Covers the entire field of antiviral drug discovery and development * Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 * Summarizes the successes of the past years in developing ground-breaking medicines against 7 major human viruses, both from the medicinal chemistry and the pharmacological angle * Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues 'New Drug Development for Known and Emerging Viruses' is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

Computer-controlled chemical synthesis using flow chemistry microreactors is the key enabling technology for the chemistry laboratory of the future. Early adopters of this ground-breaking technology describe current and future uses in medicinal chemistry.