Bøker i Molecular Medicine And Medicinal Chemistry-serien

Merkel cell carcinoma is an uncommon but not rare aggressive cutaneous malignancy. This book summarizes the knowledge about Merkel cell carcinoma and provides a perspective on future opportunities for diagnostic and therapeutic advances. It also offers practical how to advice on diagnosis, treatment and follow-up.

Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. This title offers guidance to those evaluating and preparing to enter particular areas within the field.

MicroRNAs have emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. This book discusses how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease.

Covers the understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge.

Focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. This title introduces various concepts on the challenges relating to the development of resistance by androgen-independent tumors, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways.

Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers' understanding of oligomerisation and fibril formation.