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Frontmatter -- Contents -- Introduction / Ackermann, R. -- Transurethral prostatic surgery at the Mayo Clinic / Utz, D. C. -- Morphological aspects of the human prostate and the development of benign prostatic hyperplasia / Aumüller, G. -- Stem cell organization of the prostate and the development of benign prostatic hyperplasia / Isaacs, J. T. -- Benign prostatic hyperplasia: morphometric studies in relation to the pathogenesis / Bartsch, G. / Brüngger, A. / Schweikert, U. / Hintner, H. / Höpfl, R. / Rohr, H. P. -- The extracellular matrix and cellular proliferation in the etiology of benign prostatic hyperplasia / Mawhinney, M. -- Steroid hormones, receptors and benign prostatic hyperplasia / Romijn, J. C. -- Growth factors in benign prostatic hyperplasia / Lawson, R. K. / Story, M. T. / Jacobs, S. C. / Begun, F. P. -- Transurethral prostatectomy - complications / Bandhauer, K. -- Results of surgical management of BPH - TUR-P by cold punch technique / Bülow, H. -- Urodynamic implications of benign prostatic hyperplasia, parameters and suggestions for the set-up of prostatic studies / Jensen, K. M.-E. / Anderson, J. T. -- Conservative nonhormonal treatment of patients with benign prostatic hyperplasia / Dreikorn, K. / Richter, R. -- Management of benign prostatic hyperplasia with antiandrogens and antiestrogens - clinical results (Review) / Tenaglia, R. / Silverio, F. Di -- Androgen ablation in the treatment of stage II benign prostatic hyperplasia / Schröder, F. H. / Bosch, R. J. L. H. / Blom, J. H. M. -- Aromatase inhibitors in the management of benign prostatic hyperplasia / Tunn, U. W. / Schweikert, H. U. -- Closing remarks / Frohmüller, H. -- Contributors

Frontmatter -- Contents -- Opening remarks / Hannse, H. -- Prologue / Greenblatt, R. B. -- 1. Physiology and pathophysiology of the perimenopausal years -- Some aspects of oogenesis, follicular growth, and endocrine involution / Nocke, W. -- The climacteric syndrome / Schneider, H. P. G. -- Skin and the menopause / Brincat, M. -- Osteoporosis: occurrence and diagnosis / Lindsay, R. -- Lipids, hormonal status and the cardiovascular system in the postmenopause / Tikkanen, M. J. / Nikkila, E. A. / Kuusi, T. -- Psychosocial aspects in the perimenopause / Wenderlein, J. M. -- The bladder in the menopausal woman / Versi, E. -- Discussion -- 2. Management of the climacteric patient -- 2.1. General aspects -- The influence of nutrition and exercise / Notelovitz, M. -- Non-hormonal medication / Utian, W. H. -- Discussion -- 2.2. Hormonal treatment -- Selection of patients - kind and duration of treatment / Studd, J. W. W. / Andersen, H. M. / Montgomery, J. C. -- Routes of estrogen administration / Cardozo, L. -- Sex steroids and lipoproteins / Larsson-Cobn, U. / Wallentin, L. -- Discussion -- 2.3. Risk-benefit evaluation of hormonal therapy -- Prospective study on long term risk of hormone replacement therapy / Hunt, K. / Vessey, M. -- Long-term metabolic effects of estrogen therapy / Husmann, F. -- Hormonal replacement therapy and breast cancer / Gambrell, R. D. -- Prevention of endometrial abnormalities / Whitehead, M. I. -- Estrogen/progestogen as a prophylactic treatment of postmenopausal osteoporosis / Christiansen, C. -- Discussion -- 2.4. Special aspects in premenopausal women -- Management of the premenstrual syndrome / Magos, A. L. / Studd, J. W. W. -- Contraception in premenopausal age / Schwartz, U. -- Discussion -- Closing remarks / Crosignani, P. G. -- Epilogue / Greenblatt, R. B. -- List of contributors -- Backmatter

Frontmatter -- Welcome address / Flamigni, C. -- Contents -- Introduction / Haspels, A. A. / Vange, N. van der -- Antiandrogen therapy for signs of androgenization: an overview / Schindler, A. E. -- I. Pharmacology and physiology -- Pharmacological aspects of cyproterone acetate / Neumann, F. -- Pharmacokinetics of cyproterone acetate and ethinyl estradiol in smoking and non-smoking women during treatment with Diane-35 / Zurth, Chr. / Täuber, U. -- Ovulation inhibitory effect of SH B 209 AE (Diane-35)-a new antiandrogen-estrogen combination / Spona, J. / Huber, J. / Schmidt, J. B. -- A study to investigate the maintenance of ovulation inhibition when patients switch over from Diane to Diane-35 / Higgins, H. P. / Davies, T. G. / Hutchinson, P. E. -- Effect of a new antiandrogen-estrogen sub-fifty combination on the endometrium / Fedele, L. / Marchini, M. / Carinelli, S. G. / Zamberletti, D. / Baglioni, A. -- II. Polycystic ovary syndrome -- Endocrinological and clinical findings on the therapy with Diane-35 in polycystic ovary syndrome / Falsetti, L. / Casarotti, G. A. / Gastaldi, A. -- Discussion -- III. Effects on the haemostatic system -- Longitudinal study on the effects of a cyproterone acetate and ethinyl estradiol combination on haemostasis / Bruni, V. / Bucciantini, S. / Rosati, D. / Verni, A. / Abbate, R. / Pinto, S. -- Haemorheological effects of Diane-35 and Microgynon®-Preliminary results of a double blind study / Ernst, E. / Schmölzl, Ch. / Matrai, A. / Schramm, W. -- Antiandrogen treatment in women with acne: a controlled trial / Ashton, R. E. / Miller, J. A. / Wojnarowska, F. T. / Dowd, P. M. / O'Brien, T. J. / Griffiths, W. A. D. / Jacobs, H. S. -- IV Special aspects -- Clinical assessment of two antiandrogen treatments, cyproterone acetate combined with ethinyl estradiol and spironolactone in hirsutism / Rubens, R. / Vermeulen, A. -- Treatment of severe androgenization symptoms with Diane and intramuscularly applied cyproterone acetate (Androcur Depot) / Kaiser, E. -- One-year experience with a new oral contraceptive using natural estradiol and cyproterone acetate / Hirvonen, E. / Stenman, U.-H. / Vartiainen, E. -- Discussion -- V. Metabolic and clinical aspects -- Clinical and metabolic effects of a new estrogenantiandrogen low dose combination / Cecco, L. De / Capitanio, G. L. / Bertolini, S. / Croce, S. / Centonze, A. -- Effects of cyproterone acetate on serum lipoproteins when administered alone and in combination with ethinyl estradiol / Silfverstolpe, G. / Lindberg, U.-B. / Enk, L. / Samsioe, G. / Crona, N. -- Clinical, metabolic and endocrine effects of long term use of a cyproterone acetate and ethinyl estradiol combination in hyperandrogenized women / Gaspard, U. J. / Bonnivert, J. / Emonts, P. / Gillain, D. / Lambotte, R. -- Cyproterone acetate versus levonorgestrel combined with ethinyl estradiol in the treatment of acne : results of a multi-center study / Carlborg, L. -- Comparison of Diane-35 with Neo-Eunomin from the dermatological viewpoint / Nürnberger, F. -- A double blind comparative study of tetracycline and Diane, alone and in combination in the treatment of acne / Greenwood, R. / Brummitt, L. / Burke, B. / Cunliffe, W. J. -- The comparative efficacy and safety of Diane- 35 versus Diane-50 in the treatment of moderate to severe acne and seborrhea: preliminary results / Fugère, P. / Percival-Smith, R. K. L. / Lussier-Cacan, S. / Tétrault, C. / Farquhar, D. J. -- Results of an extended open phase m study with Diane-35 / Aydinlik, S. -- Discussion -- Closing remarks / Lachnit-Fixson, U. -- List of first-mentioned contributors

Frontmatter -- Contents -- I. Mechanism of hormonal action at cellular level and biochemistry -- Mechanism and effects of androgen withdrawal therapies / Bruchovsky, N. / Rennie, P. S. / Goldenberg, S. L. -- Target-cell response to androgen withdrawal / Voigt, K. D. / Klein, H. -- Effects of chronic treatment with an LH-RH agonist on human testis tissue / Huhtaniemi, I. T. -- Animal models for prostate cancer / Otto, U. / Wagner, B. / Kloppel, G. / Baisch, H. / Klosterhalfen, H. -- The significance of the nude mice model for studies on human prostatic carcinoma / Steenbrugge, G. J. van / Jong, F. H. de / Gallee, M. P. W. / Schroder, F. H. -- II. Etiology and experimental basis of therapy -- Etiology and natural history of early prostatic cancer / Schröder, F. H. -- Pharmacological basis of androgen deprivation by various antiandrogens and their combination with LH-RH agonists / Neumann, F. / El Etreby, M. F. / Habenicht, U.-F. / Radlmaier, A. / Bormacher, K. -- III. Clinics -- Evaluation of different endocrine approaches in the treatment of prostatic carcinoma / Turkes, A. O. / Peeling, W. B. / Wilson, D. W. / Griffiths, K. -- Rationale of total androgen blockade by cyproterone acetate / Tunn, U. W. -- Clinical experience with Androcur® in the treatment of prostatic cancer / Becker, H. / Klosterhalfen, H. -- Prostate cancer treatment: tolerance of different endocrine regimens / Varenhorst, E. -- Result of long-term treatment with cyproterone acetate (CPA) in advanced prostatic cancer patients / Di Silverio, F. / Sciarra, F. -- Results and experience with the androgen ablation therapy: current trends in the USA / Kirchheim, D. -- Long-term results of an LH-RH agonist monotherapy in patients with carcinoma of the prostate and reflections on the so-called total androgen blockade with pre-medicated cyproterone acetate / Jacobi, G. H. -- List of first-mentioned contributors