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This issue of Immunology and Allergy Clinics, guest edited by Mariana C. Castells, MD, is devoted to Mastocytosis. Articles in this issue include: New Insight into Clonal Mast Cell Disorders Including Mastocytosis; Cutaneous Mastocytosis in Adults and Children: New Classification and Prognostic Factors; Hymenoptera Anaphylaxis as a Clonal Mast Cell Disorder; Non Clonal Mast Cell Activation Syndrome:  A growing body of evidence; Familial Tryptasemia Syndromes: Genotyping and Symptoms; POTS and EDS: Entities Associated to Mast Cell Activation; KIT Mutations: New Insight and Diagnostic Value; Patients'' Perceptions in Mast Cell Activation Disorders; Mast Cell Mediators of Significance in Clinical Practice; Tyrosine Kinase Inhibition in Mast Cell Activation Disorders; Gastrointestinal Involvement in Mast Cell Activation Disorders; Bone Marrow Expression of Mast Cell Disorders; Genomics and Proteonomics in Clonal Mast Cell Disorders; and Pediatric Expression of Mast Cell Activation Disorders.

This issue of Heart Failure Clinics--edited by Drs. Giuseppe Limongelli, Sharlene Day, and Perry Elliott--will cover Clinical and Molecular Aspects of Cardiomyopathies: On the Road from Gene to Therapy. Topics include, but are not limited to, Epidemiology and Clinical aspects of Genetic Cardiomyopathies, Existing and New therapies, Gene editing and gene-based therapeutics, Controversies surrounding exercise in genetic cardiomyopathies, Genetic infiltrative cardiomyopathies, LV Noncompaction, Clinical presentation and natural history of hypertrophic cardiomyopathy in Rasopathies, and Moelcular basis and new treatments of cardiac diseases in Rasopathies.

This issue of Rheumatic Disease Clinics, guest edited by Dr. Sindhu Johnson, will cover Advances in Epidemiologic Methods to Study Rheumatic Diseases. This unique volume will discuss the following topics, among others: Minimal clinically important difference (MCID) for outcome measures, Alternative longitudinal study designs, Propensity score methods for observational data, Approaches to deal with missing data, Applied Bayesian Methods in Rheumatology, Qualitative methods, Similarity Network Fusion, Systematic reviews/meta-analysis and randomized trials, and Integrated analysis of data obtained in various reading campaigns of images.

This issue of Psychiatric Clinics, guest edited by Dr. Thomas Franklin, will provide a unique look into several key topics in Psychodynamic Psychiatry. Articles in this volume include, but are not limited to: Preserving the Person in contemporary psychiatry, Psychodynamic psychiatrist as advocate, The role of Personality Dynamics and Disrupted Grieving, Obstacles for Parity for Psychotherapy Benefits, Psychodynamic Theory and Treatment of PTSD, Using Transference-Focused Psychotherapy (TFP) principals in Acute Care Settings, The Overall Diagnosis, Innovative educational initiatives to train psychodynamic psychiatrists in underserved areas of the world, and Psychodynamic treatment of substance use disorders.

This issue of Endocrinology and Metabolism Clinics, edited by Dr. Ashley Grossman, will focus on Innovations in the Management of Neuroendocrine Tumors. Topics include, but are not limited to, Molecular targeted therapy of NETs - State of the art; Surgical approaches to the management of liver metastases; Liquid biopsies for NETs - circulating tumour cells and DNA; Novel functional imaging of NETs; The problem of appendiceal carcinoids; Peptide radioreceptor therapy comes of age; Current chemotherapy use in NETs; The problem of grade 3 NETs; Molecular genetic studies of pancreatic neuroendocrine tumours reveal new therapeutic approaches; The new WHO classification; Gastrinomas - medical or surgical treatment; When and how to use somatostatin analogues; The NETest as the way forward; Lung and thymic carcinoids; Carcinoid heart disease; Gastric carcinoids; New treatments for the carcinoid syndrome; and The genesis of the NETs concept - From Oberdorfer to 2018.

With consultation of Dr. Bonita Stanton, Consulting Editor, Drs. Li and Higgins have secured experts in the field to provide clinical reviews on the latest updates in diagnosing and treating children with rheumatologic disease. The issue contains articles on the following topics: Approach to the Child with Joint Pain; What goes wrong that Leads to Rheumatic Disease; Juvenile Idiopathic Arthritis; Spondyloarthropathies; Systemic Arthritis; Systemic Lupus Erythematosus; Sjogren's and Mixed CTD in Children and Adolescents; Idiopathic Inflammatory Myopathies in Children; Juvenile Scleroderma; Chronic Non-Infectious Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis; Non-Inflammatory Musculoskeletal Pain in Children or Pediatric Pain Syndromes; Complications of Immunosuppressive and Biologic Response Modifier Therapy; General Health Concerns and Fitness for the Child with Rheumatic Disease; Transition of Rheumatic Disease Care: Pediatric to Adult Care; and Advocacy for Children with Rheumatic Diseases. Readers will be able to utilize the information in the issue to improve outcomes in patients with rheumatologic disease.

With collaboration from Consulting Editor Dr. Norman Gitlin, Dr. Rosenthal has created an issue that provides current clinical information on the diagnosis and treatment of liver diseases in children. Expert authors from top institutions have contributed review articles on the following topics: Biliary atresia; Alagille Syndrome; Hepatitis B & C in Children; NAFLD/NASH; Bile acid defects; Progressive Familial Intrahepatic Cholestasis; Autoimmune hepatitis/PSC/Overlap syndrome; Portal hypertension/Cirrhosis in Children; Alpha-1-antitrypsin deficiency; Hepatic tumors; Acute Liver Failure; and Liver transplantation in Children. Readers will come away with the information they need to make clinical decisions that will improve patient outcomes.

This issue of Critical Care Clinics, guest edited by Drs. Marie Baldisseri, Mary Reed, and Randy Wax, in collaboration with Consulting Editor John Kellum, is devoted to Intensive Care Unit in Disaster. Topics in this issue include: Intensive care role in disaster management; Preparing the ICU for disaster; Augmenting capacity; Triage; Natural disasters; Biological/pandemic disasters; Chemical disasters; Radiation; Anthropogenic (terrorist/criminal act) disasters; Special populations (i.e., chronically ill, morbidly obese, pregnant); Pediatrics; Austere environments; Hospital as disaster Ground Zero; and Special considerations (i.e., mental health, ethics, public relations).

This issue of Interventional Cardiology Clinics will explore Transcatheter mitral valve repair and replacement. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Transcatheter Mitral Valve Direct Annuloplasty With the Millipede Device, Transcatheter Mitral Valve Replacement with Intrepid, Transcatheter Mitral Valve Replacement with Tendyne, Treatment of functional mitral regurgitation with transcatheter edge-to-edge repair, Transcatheter Edge-to-Edge repair for Degenerative Mitral Regurgitation, Predicting Left Ventricular Outflow Tract Obstruction Following Transcatheter Mitral Valve Replacement, Prevention and Treatment of Left Ventricular Outflow Tract Obstruction after Transcatheter Mitral Valve Replacement, and Transatrial implantation of transcatheter heart valve for mitral disease, among others.

In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Paul Edward Sax has put together a state-of the-art issue of the Infectious Disease Clinics of North America devoted to HIV. Clinical review articles from expert authors are specifically devoted to the following topics: HIV Diagnostics -- Current Recommendations and Opportunities for Improvement; Update on HIV Prevention -- PreP, PEP, and Other Strategies; Initial Assessment -- What Tests to Order and Why; Why Everyone (Almost) with HIV Needs to be on Treatment -- A Review of the Critical Data; Initial Therapy in the Integrase Inhibitor Era -- Can We Do Better than Two NRTIs plus an INSTI?; Switching Therapy in Patients with Virologic Suppression -- A Why and a How-To Guide; Management of Treatment Failure, With and Without Resistance; Reproduction Options for People with HIV, and Management of Pregnancy; HIV and Addiction - the Role of the ID Clinician; Management of Patients with Advanced HIV Disease - Challenges and Opportunities; HIV and Aging - Focus on Cardiovascular Risk and Metabolic Abnormalities; Key Principles in HIV Pharmacology; One Patient Has Been Cured of HIV - Will There Ever Be More?; and Linkage and Retention in Care - The Keys to Treatment Success. Readers will come away with the latest information they need to manage diagnosis, treatment and outcomes of HIV patients.

Drs. Robert Wachter and Lee Goldman coined the term hospitalist in their New England Journal of Medicine article in 1996. Hospital Medicine is now the fastest growing medical specialty in the United States, due in part to the evolution of inpatient care. In this issue, the Guest Editor, Dr. Nancy Spector, and Consulting Editor Dr. Bonita Stanton, have assembled expert authors to examine the changing nature of inpatient care, including the major movements and trends that have influenced hospital-based practice, patient centered care, and education in this clinical learning environment. Articles are focused on the following: Quality of Care and Quality Improvement; Evidence-based Medicine; Patient Outcomes and Metrics; Inter-professional Teams; Handoffs; Patient Centeredness; Communication with Patients; Health Literacy; Bedside Rounds; Education in the Inpatient; Clinical Learning Environment and Workplace-based Assessment; Simulation in Medical Education; Feedback; Bedside Teaching and Learning; and Hospital Medicine: State of the Specialty, Looking Forward. The intended audience for this issue are frontline providers that provide care in community hospitals and faculty in academic medical centers. Pediatricians will come away with the information they need to improve patient outcomes with evidentiary support.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Dr. Lisa Kobrynski, is devoted to Primary Immune Deficiencies. Articles in this issue include: Personalized therapy: Immunoglobulin replacement for antibody deficiency; Newborn Screening for Severe Combined Immunodeficiency: Update on newborn screening and lessons learned; Update on Advances in Hematopoietic Cell Transplantation for Primary Immunodeficiency Disorders; Hereditary Autoinflammatory Disorders: Recognition and treatment of inflammatory disorders of the immune system; Use of Immunomodulatory Agents to Treat Primary Immune Deficiencies: Mechanism-based therapy; Secondary Hypogammaglobulinemia: An increasingly recognized complication of treatment with immunomodulators and post-solid organ transplantation; Use of Vaccines in Primary Immunodeficiency; Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders; Hyper IgE Syndromes; Early Onset Inflammatory Bowel Disease; and Genome Testing to Diagnose Primary Immunodeficiency Disorders and to Identify Targeted Therapy.

This issue of Hematology/Oncology Clinics, guest edited by Drs. Nicole R. LeBoeuf and Cecilia Larocca, with consulting editors George Canellos and Franklin Bunn, will focus on Cutaneous Malignancy. Topics include, but are not limited to, Squamous Cell Carcinoma, Basal Cell Carcinoma, Melanoma, Malignant Neuroendocrine Tumors, Mycosis Fungoides/Sezary Syndrome, CD30+ lymphoproliferative Disorders, Rare Cutaneous T Cell Lymphoma, Cutaneous Involvement of Hematologic Malignancies, Cutaneous B Cell Lymphoma, Adnexal Tumors, Extramammary Paget''s Disease, Cutaneous sarcomas, and Cutaneous metastases.

In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Vivian Chu has created an issue that provides current clinical updates on device-associated infections. Authors are represented by experts across the world, who have contributed clinical reviews on the following topics: Intravascular Catheter-Related Bloodstream Infections; Vascular Graft Infections; Cardiovascular Implantable Electronic Device-Associated Infections; Left Ventricular Device-Associated Infections; Urinary Catheter-Associated Infections; Prosthetic Joint Infections; Neurosurgical Device-Related Infections; Breast Implant Infections; Cochlear Implant Infections; Gastrointestinal Scope-Related Infections; Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated infections;  and Infections of Hemodialysis Access Devices. Readers will come away with the information they need to make informed clinical decisions that improve patient outcomes.

Guest edited by Dr. Daniel Levi, this issue of Interventional Cardiology Clinics will cover several key areas of interest related to Congenital Heart Disease Intervention. This issue is one of four selected each year by our series Editor-in-Chief, Dr. Matthew Price of Scripps Translational Science Center. Articles in this issue include, but are not limited to: Current Transcatheter Approaches for the Treatment of Aortic Coarctation in Children and Adults, Biodegradable Stents for Congenital Heart Disease, State of the Art ASD Closure Devices for Congenital Heart, New PDA Closure Devices and Techniques, Lymphatic Interventions, VSD Closure Devices, Techniques and Outcomes, Pulmonary Artery and Bronchial Stenting: Available Devices, Techniques and Outcomes, and Transcatheter Valve, and Interventions for Adults with Congenital Heart Disease.

With consultation of Dr. Bonita Stanton, Dr. James Chan has assembled a comprehensive list of articles that update the topic of kidney disorders in children. He has secured expert authors from around the world to contribute clinical reviews on the following topics: Urinary tract infection; Hematuria and proteinuria; Metabolic syndrome in childhood obesity; Hypertension; Post-infectious glomerulonephritis; Nephrotic syndrome and glomerular disease; Lupus nephritis; IgA nephropathy and anaphylactoid purpura nephropathy; Tubulointerstitial nephritis; Bartter syndrome and Gitelman syndrome; Renal tubular acidosis; Fanconi syndrome; Dent disease; Hypophosphatemic rickets; Syndrome inappropriate ADH secretion (SIADH); Nephrogenic diabetes insipidus; Hemolytic uremic syndrome and other acute kidney injuries; Chronic kidney disease and dietary measures to slow progression; and Long-term outcome of renal transplantation. Readers will come away with the most current clinical information they need to inform decisions to improve outcomes in pediatric patients.

In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Jo-Ann Young has put together a state-of the-art issue of the Infectious Disease Clinics of North America devoted to Management of Infectious Diseases in Stem Cell Transplantation and Hematologic Malignancy. Clinical review articles from expert authors are specifically devoted to the following topics, addressing both the stem cell transplant recipient and the hematologic malignancy patient: Chemotherapy Regimens for Hematologic Malignancies and Issues That Affect Infection; Stem Cell Transplantation Technical Issues That Affect Infection in The Recipient; Complications of Stem Cell Transplantation That Cause Infections; Antimicrobial Prophylaxis and Preemptive Agents and Regimens for the Prevention of Infection; Workup for Fever During Neutropenia; Herpesvirus Infections; Cytomegalovirus Infections; Respiratory Virus Infections; Other DNA Virus Infections; Bacterial Infections; Fungal Infections; Parasitic Infections; Vaccination; and Immunoglobulin Replacement. Readers will come away with the latest information they need to manage infections and improve outcomes in these patients.

This issue of Physician Assistant Clinics, Guest Edited by Jane McDaniel of Yale University, is devoted to Laboratory Medicine. Articles in this issue include: Rheumatology; Sexually Transmitted Infections; Provider Performed Microscopy Procedures; New Methods in Dementia Testing; Cardiology Testing; Thyroid Testing; Renal Function Testing; Anti-Xa for Heparin Monitoring and other Coagulation Studies; ABG Interpretation; Transfusion Medicine; Diagnostics for WBC Abnormalities: Leukocytosis/Leukopenia; Anemia Diagnostics for Iron Deficiency, B12/Folate Deficiency, Thalassemias, and Anemia of Chronic Disease; Hematology Testing for Hemolytic Anemias; and Liver Function Testing.

This issue of Clinics in Geriatric Medicine, Guest Edited by William B. Ershler, MD of the Institute for Advanced Studies in Aging and Geriatric Medicine, is devoted to Anemia in the Older Adult. Articles in this important issue include: Aging and Hematopoiesis; Prevalence of Anemia in Older Populations; Functional Consequences of Anemia in Older Patients; Mechanisms of Anemia in Older Populations; Unexplained Anemia in Older Populations; Significance of Elevated RDW in Older Populations; Iron Deficiency; Vitamin B12; Myelodysplasia; Chronic Kidney Disease and Anemia in Older Populations; Inflammation, Aging and Anemia; Emergence of Sickle Cell Disease in Older Populations; Heyde''s Syndrome; and Special Considerations for Anemia in the Nursing Home.

This issue of Cardiology Clinics, guest edited by Drs. Silvi Shah and Charuhas V. Thakar, will focus on Diabetes/Kidney/Heart Disease. Topics include, but are not limited to, Cardiorenal syndrome-Pathophysiology; Cardiorenal syndrome- treatment; Hypertensive Emergencies; Contrast induced acute kidney injury; Acute Kidney Injury, Heart failure, and health outcomes; Hypertension management in CKD/ESRD/DM; Arrhythmias/ICD/LVAD, Afib, and dialysis; Apol1 and blood pressure changes/hypertension; Novel ant-diabetic therapies and CV reduction; and Hypertensive disorders of pregnancy.

This issue of Sleep Medicine Clinics, guest-edited by Drs. Rachel Markwald and Anne Germain, focuses on Sleep and Performance. This issue is one of four selected each year by series Consulting Editor, Dr. Teofilo Lee-Chiong. Articles include: Work productivity and sleep issues; Sleep apnea and performance; Sleep and athletic performance: the role of untreated sleep issues in sports; Early detection of sleep disorders in safety critical jobs; Insomnia and performance; Exercise for improving insomnia symptoms: implications on performance; Sleep and athletic performance: sleep and visuomotor performance; Brain stimulation for improving sleep and memory; Prevalence of sleep disorders in students and academic performance; PTSD/TBI, Sleep, and Military Operational Performance; New technology for measuring sleep and assessing sleep disorders: implications for public health and safety; and Use of hypnotic medications on learning and memory consolidation.

In collaboration with the Consulting Editors, Ranjan K. Thakur and Andrea Natale, Drs. David R. Holmes Jr., Saibal Kar, Dhanunjaya Lakkireddy, and Vivek Reddy have assembled an issue of Cardiac Electrophysiology Clinics on Left Atrial Appendage. Topics include, but are not limited to, why we have an atrial appendage, thromboembolism in AF, role of LAA in systemic homeostasis, history of LAA closure, impact of LAA closure on systemic thromboembolization, perirprocedural imaging, anatomical considerations for epicardial and endocardial appendage closure, epicardial vs endocardial closure, technical considerations of endocardial and epicardial closure, surgical LAA occlusion, post procedural management, AF patients undergoing ablation, and more.

For this important and unique issue of Gastroenterology Clinics, Consulting Editor Dr. Alan Buchman decided to serve as co-Guest Editor with Dr. David Hackam to provide a "bench to bedside” look at intestinal failure. Authors have contributed reviews on the status of the science behind artificial organs while emphasizing how to clinically prepare for intestinal failure. Articles are devoted to the following topics: Initial Evaluation and Care of the Patient with New Onset Intestinal Failure; Getting the Patient Ready for Home Parenteral Nutrition; Pediatric Intestinal Failure:  Etiology and Management; Predictors of Intestinal Adaptation in Children; Management of the Patient with Chronic Intestinal Pseudo-obstruction and Intestinal Failure; Intestinal Growth and Adaptation Following Resection in Intestinal Failure; Fluid and Electrolyte Management and Prevention of Dehydration in Intestinal Failure; The Oley Foundation and Consumer Support Groups; Weaning from Parenteral Nutrition; Hepatobiliary Complications of Intestinal Failure; Non-Transplant Surgery in Intestinal Failure; Indications for Intestinal Transplantation in Intestinal Failure; Intestinal Regeneration and the Artificial Gut; Bench to Bedside Approaches for Engineered Intestine, Esophagus and Colon; and Fetal and Amniotic Stem Cells in Gut Engineering. Readers will come away with a true state-of-the-art look at how to manage intestinal failure.

This issue of Critical Care Clinics, guest edited by Drs. Hernando Gomez Danies and Joseph Carcillo, focuses on Coagulation/Endothelial Dysfunction. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Cell-cell communication breakdown and endothelial dysfunction; Role of the Tie2/Angiopoetin pathway in endothelial dysfunction; The Glycocalyx; Platelet activation and endothelial dysfunction; Role of antithrombin III and tissue factor pathway; Red blood cell dysfunction; Microvascular hemodynamics, autoregulation and mechanotransduction control of blood flow distribution; Nitric oxide and endothelial dysfunction; Microvascular dysfunction; Hemolytic Uremic Syndrome and atypical HUS; Thrombotic thrombocytopenic purpura, Heparin induced thrombocytopenia and Disseminated intravascular coagulation in the critically ill; Thrombocytopenia associated multiple organ failure (TAMOF); Meningococcemia; Immune consequences of endothelial dysfunction during sepsis; Therapeutic targets in thrombotic microangiopathies with a focus on endothelial disorders; and Coagulation disorders in HLH/Macrophage activation syndrome.

Approx.240 pages

This issue of Critical Care Clinics, Guest Edited by Dr. Stephen M. Pastores and Dr. Wendy R. Greene, focuses on Critical Care of the Cancer Patient (Pastores) and Geriatric Critical Care (Greene). Dr. Pastores'' section of the issue is devoted to Critical Care of the Cancer Patient and includes the following topics: Triage and Prognostication of Cancer Patients Admitted to the ICU; ICU Organization and Interdisciplinary Care for Critically Ill Patients with Cancer; Critical Care of the Hematopoietic Stem Cell Transplant Recipient; Management of Drug Toxicities; Acute Kidney Injury in the Critically Ill Patient with Cancer; Infectious Disease Complications in Cancer Patients; and Palliative, Ethics, and End-of-Life Care Issues in the Cancer Patient. Dr. Green''s section of the issue, devoted to Geriatric Critical Care, includes the following topics: The effect of aging physiology on critical care; The frailty syndrome: a critical issue in geriatric oncology; Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratings; Evidence-based geriatric nursing protocols for best practice; The effect of dementia in the critically ill geriatric patient; Nutritional assessment: a primary component of multidimensional geriatric assessment in the ICU; Rehabilitation concerns in the geriatric critically ill and injured; and Geriatric palliative care.

Approx.240 pages

Approx.240 pages

Presents articles that deals with therapies for treatment of HCV. This title addresses such novel therapies as interferons, viral kinetics and anti-viral resistance, anti-fibrotics, immunotherapeutics, hepatoprotectants and caspace inhibitors, and cyclosporine analogues.

Addresses movement disorders. This title contains the following articles: Etiogenesis of Parkinson's Disease; Medical Treatment of Parkinson's Disease; Surgical Treatment of Movement Disorders; Tremor: Clinical Features, Pathophysiology and Treatment; Dystonia - Genetics and Treatment; and, Huntington's Disease and Other Choreas.