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Includes topics on: A Critical re-appraisal of Factor VIIa; Thrombocytopenia: Hit vs non-HIT causes; Transfusion Reactions: Newer concepts on the pathophysiology, incidence, treatment and prevention of TRALI; The utility of diagnostic scoring systems for DIC; Newer anticoagulants; The role of plasmapheresis in critical illness; and more.

Reviews Venous Thromboembolism, a critical area for pulmonary medicine specialists. This title offers an epidemiological overview and looks at the following topics: use of clinical probability algorithms (Geneva Score, Wells Criteria, and others), imaging techniques, deep vein thrombosis prophylaxis, and upper extremity DVT.

Assembles top experts to write reviews on the management of chronic myelogenous leukemia. This title includes articles: Selection of Therapy: Rational Decisions Based on Molecular Events; Is There a Potential Cure for CML in Current Therapies? Hurdles Toward a Cure for CML: The CML Stem Cell; and, Management of Ph+ ALL and CML Blast Crisis.

Discusses such topics as: the population genetics and dynamimcs of thalassemia; alpha thalassemia; HbE/beta thalassemia; management of iron overload in thalassemia syndromes; allogeneic cellular gene therapy for hemoglobinopathies; cord blood transplantation for beta thalassemia major; and, gene therapy for haemoglobin disorders.

Acute respiratory infections are responsible for an estimated 4 million deaths annually worldwide, and are the leading cause of death in children younger than 5 years. Over 1 million people in the United States are hospitalized each year with pneumonia. Mycobacterium tuberculosis infects one third of world's population. There are more than 1 million tuberculosis-related deaths worldwide each year. Emerging resistance to multiple available antimicrobial agents has hampered the ability to treat tuberculosis and hospital-acquired respiratory infections. The laboratory diagnosis of respiratory infections is an important part of patient management and treatment. In addition to culture isolation of pathogens, advances have been made in a number of non-culture methods. This issue of Clinics in Laboratory Medicinee reviews state-of-the-art laboratory diagnosis of respiratory infections, as well as the testing of susceptibility to antibiotics and antiviral agents. Among some of the respiratory infections covered are: Cystic fibrosis infections; Pertussis; Pharyngitis; Fungal infections. Among the diagnostic tests are: Interferon gamma release assays; Molecuar diagnosis of TB; Urine antigen tests and discussion of Antibiotic resistance in nosocomial respiratory infections.

Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

This issue of Rheumatic Disease Clinics is devoted to Sjogren's Disease. The articles will include everything from the Use of Biologics, Autoantibodies, and Genetics, to Proteomics of Saliva/Tears, Parotid Biopsy, Use of Ultrasound, and many more!

The understanding of hemostasis physiology has been considerably advanced by models of kinetics and by the complicated interplay of cells and soluble coagulation factors. This book explains how this physiology is reflected in clinical laboratory testing.

Covers such topics as: the size and burden of Anxiety worldwide - an update, patterns of comorbidity and the structure of anxiety and mental disorders revisited - lumping or splitting, anxiety and anxiety disorders in children and adolescents - developmental issues, precursor conditions, etcetera and Public Health Perspective - Why did we fail?

Provides important updates in myopathies. This title covers topics such as: clinical features, pathophysiology, and treatment of polymyositis and dermatomyositis; inclusion body myositis; metabolic myopathies; drug-induced myopathies; muscular dystrophies and neurologic diseases; and, more.

Suitable for surgical pathologists, this title presents concepts in pathology diagnosis, key features, differential diagnosis, overview, pitfalls, and molecular approaches for various disease entities and body regions.

Discusses issues in gastroenterology unique to female patients. This title features articles that help readers to determine whether gender influences diagnosis and treatment of functional disorders, evaluate problems in the pregnant patient, explain immune diseases of the GI, and discuss unique genetic aspects of Lynch Syndrome and IBD.

Offers practical approaches to controversies in obstetrical care. This issue reviews issues including recurrent spontaneous pregnancy loss, treatment of thromboembolic events prior to or during pregnancy, multiple gestations, complications surrounding severe preeclampsia, and care for the pregnant patient with an underlying seizure disorder.

Palliative care focuses on reducing the severity of disease symptoms in order to prevent and relieve suffering and to improve the quality of life for people facing serious, complex illness. This issue covers important topics in palliative care, such as prognosis, management of several end-stage diseases, and management of severe symptoms.

An issue that covers a broad selection of topics critical to psychiatrist and any physician who treats older patients. It includes: epidemiology, clinical evaluation, and treatment of dementing disorders, late-life psychosis; suicide in late life; depression in primary care; and structural neuroimaging of geriatric depression.

Covers: exocrine pancreatic tumors of non-ductal origin: acinar carcinoma, pancreatoblastoma and solid-pseudopapillary neoplasm; pancreatic cystic tumors of mucinous type; pancreatic cystic lesions of non-mucinous type; pancreatic endocrine tumors; inflammatory lesions and pseudotumors of the pancreas; and, ductal adenocarcinoma of the pancreas.

Provides a perspective on forensic matters in child and adolescent psychiatry, with an approach that adds fresh thinking to the discussion, rather than rehashing known facts. This title includes articles that are geared toward child psychiatrists in clinical practice, providing practical information in this important area of study.

Focuses on Severe Acute Respiratory Distress Syndrome and dealing with it in the ICU. This title includes topics such as: Challenges and Successes in ARDS Research; Mechanical ventilation with Lung Protective Strategies - What works? Gene therapy for ALI/ARDS; High Frequency Oscillatory Ventilation in ALI/ARDS; and, more.

Organized to mimic the clinical process of detection, treatment, and management, this title includes articles on the biology, interpretation, and imaging of germ cell tumors; early stage and stage II of seminomas and nonseminomas; and, first, second, and third line of chemotherapy for disseminated germ cell tumors.

Features articles that deal with the use of expandable metal stents in biliary disease, esophageal disease, malignant esophageal disease, malignant biliary obstruction, as well as plastic stents and pancreatic stents. This title includes a foundation article on the principles of stents and tissue sampling.

Cardiotoxicity, and specifically LV dysfunction, remains the limiting factor for many anti-neoplastic agents. This title summarizes for the heart failure specialist the possible ways that chemotherapeutic agents might cause cardiotoxicity as well as the methods for detecting, treating and preventing cardiotoxicity.

Over the years much attention has been paid to understanding and diagnosing Sarcopenia, the loss of muscle mass that results from the process of aging. This issue covers the history of Sarcopenia and works to define Sarcopenia based on workshops and meetings on the topic. It also covers the epidemiology, physiology, and consequences of Sarcopenia.

Includes information about hormones and cancer of the breast and prostate. This book focuses on the breast, and covers topics that include: the role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; and, more.

Includes Scrotal Emergencies; Penile Emergencies; Male GU Procedures; GU Trauma;Renal Stone Disease; Renal Stone Disease; Imaging of GU Emergencies; Sexual Assault; Female GU Emergencies (non-pregnant); Pediatric UTI; and, Pediatric GU Emergencies.

Includes articles on BMI and its influence, Androgens, Cognition and Menopause, and Sexual Activity/Quality of Life.

Provides gastroenterologists with the information on clinical matters in hepatology. This title features articles addressing the spectrum of matters involving the liver, including Hepatitis C, Hepatitis B, alcoholic Hepatitis, hemochromatosis, varices, liver transplantation, non-alcoholic fatty liver disease, liver failure, and hepatic fibrosis.

Covers such topics as: Epidemiology of RCC; New Insights into the Biology of RCC; Pathology of Renal Neoplasms; Imaging in RCC; Small Renal Tumors: Prognosis and Management; The Role of Surgery in the management of RCC: Nephrectomy and metastatectomy; Cytoreductive Nephrectomy: Rationale and current Applications; and, more.

Focuses on essential topics in rhinitis. This title defines the primary clinical symptoms and their causes. It discusses a range of treatments, including the use of antihistamines, nasal corticosteroids, anticholinergics, decongestants, cromolyn, guafenesin, saline washes, capsaicin, and leukotriene antagonists.

In an age of increasing globalization, the infectious disease problems of one country have an impact on nations throughout the world. This title addresses the problems of global health. It focuses on priorities for improving health around the world.

Hepatitis C Virus is a quickly evolving area within hepatology owing to various medical therapies. This title includes review articles devoted to the following medical therapies: Boceprevir, Telaprevir, Protease Inhibitors in Development, NS5B Nucleoside and Non-Nucleoside Inhibitors.