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Volume 36 of "Progress in Drug Research" contains 5 articles and the various indexes which facilitate its use and establish the connec­ tion with the previous volumes. While all articles deal with some of the topical aspects of drug research, the contribution by Robert R. Ruffolo et al. on "Drug receptors and control of the cardiovas­ cular system: Recent advances" is indeed in its own right a mono­ graphic presentation of this important domain. The remaining four reviews provide an overview of the work in­ volved in the search for new and better medicines, with a focus on chemical, pharmacological, toxicological, biological, biochemical and molecular modeling studies. In the 31 years this series has existed, the Editor has enjoyed the help and advice of many colleagues. Readers, the authors of the in­ dividual articles, and, last but not least, the reviewers have all con­ tributed greatly to the success of PDR. Although many comments received have been favorable, it is nevertheless necessary to analyze and to reconsider the current position and the direction of such a series. So far, it has been the Editor''s aim to help spread informa­ tion on the vast domain of drug research, and to provide the reader with a tool helping him or her to keep abreast of the latest develop­ ments and trends.

While all articles deal with some of the topical aspects of drug research, the contribution by Al fred Burger on "Isosterism and bioisosterism in drug design" is of great value to those researchers who are engaged in drug design and wish to include isosteric considerations in establishing a work ing hypothesis.

Those connected with drug research, be they in industry, in universities or in clinics, are aware of these problems, and, as a result of this awareness, are all the more in need of an aid which will assist them in ascertaining the current position and in fixing future goals.