Bøker av Mateen Khan

"Laughing with Lionel the Lion: Roar-tastic Knock-Knock Jokes for Kids" is a delightful eBook that invites young readers into the playful world of Lionel the Lion and his furry friends. Inside, you'll discover a treasure trove of humor as these jungle kings and queens share their favorite knock-knock jokes. From Lionel to Tawny, Safari to Roary, each character brings their unique charm to the laughter-filled stage. Dive into the wild world of wordplay, puns, and giggles, and join Lionel and his pals on an adventure that's sure to tickle your funny bone. Perfect for children aged 4 to 10, this eBook promises hours of joy and entertainment while fostering a love for reading and storytelling. Get ready to laugh, roar, and share the fun with "Laughing with Lionel the Lion!"

Tetracyclines are well known broad spectrum antibiotics, bind with macromolecules (serum albumin and DNA). The higher binding affinity of tetracyclines for macromolecules in the body is implicated in drug stability and potency with a potential risk of macromolecular damage due to intracellular accumulation of tetracyclines. Photo- oxidation of TCs produces reactive oxygen species. Reactive oxygen species not only damage the protein but also induce strand breaks in DNA. Direct binding of tetracyclines with DNA, inducing the conformational changes, and the concomitant reduction of Cu(II), involving the formation of free radicals contribute for the strand breakage. There by indicating the essential role of hydroxyl radicals in the DNA breakage in addition to the methylation at N-3 and N-7 position of purine (A&G) which resulted mismatched of the base pairs. Thus in addition to the formation of strand breaks, the methylation of DNA bases by tetracyclines is also potentially mutagenic.