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This Special Issue, "Green and Sustainable Solvents II: A Themed Issue in Honor of Professor Giovanni Sindona on the Occasion of His 70th Birthday", aims to collect and publish recent advances in this interdisciplinary area. Research articles as well as reviews dealing with innovative techniques, alternative solvents, byproduct valorization, and new routes for the use of green solvents in industrial applications are of interest. Manuscripts on how green solvents contribute to the development of natural products research are welcome. Molecules is very pleased to host this Special Issue, and invites scientists to submit their original contributions.