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Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inferenceâ¿moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness.
The city of Moon Valley is being stalked by a savage killer that can move without sound, strike without warning, and whose howl contains a power granted only by the gods themselves. Lieutenant Hal Dillon is drawn into the killer's grisly web, and as he uncovers the incredible mystery of the killer's existence, he discovers something even more harrowing. He and the killer are united in a struggle against an enemy that has been stalking both of them for years. Hal finds himself locked in an epic battle between the forces of chaos and death, where the only way for him to win may be to disavow his own humanity. Hal and a group of his friends now must face their ultimate fears, with the fate of humanity hanging in the balance.Rajesh (Raj) Pandey is licensed mechanical engineer who has worked in medical device development for more than fifteen years. He obtained his undergraduate degree in Engineering from Mercer University, and his Master's degree in Engineering from the University of Alabama at Birmingham.
In an uncertain future, a leader would rise to power in America. General George Rath is supremely charismatic, extraordinarily bold, and eerily intelligent. Rath's powerful aura would change the political and social structure of America forever. His meteoric rise to power would sweep the country up in a maelstrom of hysteria. But Colonel James Bradford had looked into Rath's eyes and had seen a frightening power that lurked inside. As he desperately attempts to uncover the mystery behind Rath's extraordinary power, he becomes entrapped in a horrifying web of betrayal and corruption. And although Bradford's daughter Alexandria is born at a terrible cost, she carries unimaginable powers of her own. She becomes engaged in a struggle to survive against terrifying enemies, as Rath's menacing shadow shrouds her future. With her own demons screaming inside of her, testing her will and the limits of her powers, Alexandria could be the only hope for a world that is spiraling toward unthinkable devastation. The three individuals must journey through searing landscapes of fear, chaos, and conflict, across the very boundaries of human existence on a collision course with the fate of the world...
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