Bøker av Roger L. (Lundblad Biotechnology Lundblad

Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book describes methods used to establish comparability between potentially identical products, providing researchers with a critical description of studies drawn from the current literature. The text covers physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation, as well as chemical methods, including hydrogen¿deuterium exchange and trace labeling. The author shows how these methods support comparability claims for generic biologicals and assure structural integrity of active pharmaceutical ingredients in final drug products.

A comprehensive assessment of the use of biomarkers in diagnostics and prognostics, this book covers the history and current application of biomarkers, explores the technology used for the validation and study of biomarkers, and compares the various technologies used to identify and measure biomarkers. It investigates the evolution of the underlying technology and discusses the translation of basic science to clinical laboratory use and potential commercial applications. He also covers proteomics and proteomic technologies and their applications in the identification of biomarkers.

A comprehensive review of reagents used for the chemical modification of proteins, the fourth edition represents a major revision. The completely updated text is substantially larger and includes five new chapters: Alkylating Agents, Acylating Agents, Nitration and Nitrosylation, Oxidation, and Modification of Proteins with Reducing Agents. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. Much of the information is in tabular form to enable the rapid location of cited material.

A comprehensive assessment of the use of biomarkers in diagnostics and prognostics, this book covers the history and current application of biomarkers, explores the technology used for the validation and study of biomarkers, and compares the various technologies used to identify and measure biomarkers. It investigates the evolution of the underlying technology and discusses the translation of basic science to clinical laboratory use and potential commercial applications. He also covers proteomics and proteomic technologies and their applications in the identification of biomarkers.

Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book covers physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation, as well as chemical methods, including hydrogen-deuterium exchange and trace labeling.