Bøker av Sana Bahri

Idiopaticheskij legochnyj fibroz - äto hronicheskoe i progressiruüschee zabolewanie, harakterizuüscheesq aberrantnoj proliferaciej fibroblastow i nakopleniem belkow wnekletochnogo matrixa, chto priwodit k dyhatel'noj nedostatochnosti. V dannoj issledowatel'skoj rabote my wybrali karnozinowuü kislotu, bioaktiwnoe weschestwo, wydelennoe iz rozmarina, chtoby ocenit' ee äffektiwnost' in vivo na äxperimental'noj modeli fibroza legkih, inducirowannogo bleomicinom (BLM) u krys Vistar, i in vitro na fibroblastah legkih cheloweka (HLF). Perwaq chast' issledowaniq in vitro pokazala, chto CA induciruet apoptoz w HLFs w dozozawisimoj manere, soprowozhdaemyj ostanowkoj kletochnogo cikla w faze G0/G1 i aktiwaciej äxpressii signal'nyh belkow Akt, p38-MAPK i p21. Vtoraq chast' podtwerdila zaschitnoe dejstwie ätoj biomolekuly in vivo na process fibroza i okislitel'nyj stress, inducirowannyj BLM. V swete ätih rezul'tatow bylo by interesno prowerit' äffektiwnost' CA pri nekotoryh zabolewaniqh, w fiziopatologii kotoryh preobladaüt wospalenie, okislitel'nyj stress i kletochnaq proliferaciq.

Idiopathic pulmonary fibrosis is a chronic and progressive disease, characterized by an aberrant proliferation of fibroblasts and an accumulation of extracellular matrix proteins leading to respiratory insufficiency. In this research work, we chose carnosic acid, a bioactive substance extracted from rosemary, to evaluate its efficacy in vivo on an experimental model of pulmonary fibrosis induced by bleomycin (BLM) in Wistar rats and in vitro on human lung fibroblasts (HLF). The first in vitro part showed that CA induces apoptosis in HLF in a dose-dependent manner, accompanied by cell cycle arrest in the G0/G1 phase and activation of the expression of the signaling proteins Akt, p38-MAPK and p21. The second part confirmed the protective effect of this biomolecule in vivo on the fibrosis process and oxidative stress induced by BLM. In the light of these results, it would be interesting to test the efficacy of CA on certain diseases whose physiopathology is dominated by inflammation, oxidative stress and cell proliferation.