Bøker av Tze Leung (Stanford University Lai

This book presents an overview of the diverse literature on change-point methodology and describes some unifying themes and recent breakthroughs. It can be used as a second-year Ph.D. level course in statistics. It is expected to be useful to researchers and graduate students, not only in statistics but also in engineering, biomedicine, economics and finance.

This book focuses on current research and methodologies developed for re-engineering cancer clinical trials and also for "hot" areas in drug development trials such as adaptive design, seamless Phase 2-3 trials, and personalized medicine using biomarkers. Background statistical methodology is summarized in the Appendix.