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A fascinating history of a public health crisis. Compellingly written and insightful, Keep Out of Reach of Children traces the discovery of Reyes syndrome, research into its causes, industrys efforts to avoid warning labels on one suspected cause, aspirin, and the feared diseases sudden disappearance. Largents empathy is with the myriad children and parents harmed by the disease, while he challenges the triumphalist view that labeling solved the crisis. ERIK M. CONWAY, coauthor of Merchants of DoubtLargents engaging and honest account explores how medical mysteries are shaped by prevailing narratives about venal drug companies, heroic investigators, and Johnny-come-lately politicians. HELEN EPSTEIN, author of The Invisible CureFascinating. . . . Thought-provoking. BooklistWell-researched. . . . A revealing work. Kirkus ReviewsReyes syndrome, identified in 1963, was a debilitating, rare condition that typically afflicted healthy children just emerging from the flu or other minor illnesses. It began with vomiting, followed by confusion, coma, and in 50 percent of all cases, death. Survivors were often left with permanent liver or brain damage. Desperate, terrorized parents and doctors pursued dramatic, often ineffectual treatments. For over fifteen years, many inconclusive theories were posited as to its causes. The Centers for Disease Control dispatched its Epidemic Intelligence Service to investigate, culminating in a study that suggested a link to aspirin. Congress held hearings at which parents, researchers, and pharmaceutical executives testified. The result was a warning to parents and doctors to avoid pediatric use of aspirin, leading to the widespread substitution of alternative fever and pain reducers. But before a true cause was definitively established, Reyes syndrome simply vanished.A harrowing medical mystery, Keep Out of Reach of Children is the first and only book to chart the history of Reyes syndrome and reveal the confluence of scientific and social forces that determined the public health policy response, for better or for ill.Mark A. Largent, a survivor of Reyes syndrome, is the author of Vaccine: The Debate in Modern America and Breeding Contempt: The History of Coerced Sterilization in the United States. He is a historian of science, Associate Professor in James Madison College at Michigan State University, and Associate Dean in Lyman Briggs College at Michigan State University. He lives in Lansing, Michigan.

"e;Exhaustively detailed yet eminently readable, this is an important book."e;Publishers Weekly, starred review"e;Cassidy does not so much exculpate Heisenberg as explain him, with a transparency that makes this biography a pleasure to read."e;Los Angeles Times"e;Well crafted and readable . . . [Cassidy] provides a nuanced and compelling account of Heisenberg's life."e;The Harvard Book ReviewIn 1992, David C. Cassidy's groundbreaking biography of Werner Heisenberg, Uncertainty, was published to resounding acclaim from scholars and critics. Michael Frayn, in the Playbill of the Broadway production of Copenhagen, referred to it as one of his main sources and ';the standard work in English.' Richard Rhodes (The Making of the Atom Bomb) called it ';the definitive biography of a great and tragic physicist,' and the Los Angeles Times praised it as ';an important book. Cassidy has sifted the record and brilliantly detailed Heisenberg's actions.' No book that has appeared since has rivaled Uncertainty, now out of print, for its depth and rich detail of the life, times, and science of this brilliant and controversial figure of twentieth-century physics.Since the fall of the Soviet Union, long-suppressed information has emerged on Heisenberg's role in the Nazi atomic bomb project. In Beyond Uncertainty, Cassidy interprets this and other previously unknown material within the context of his vast research and tackles the vexing questions of a scientist's personal responsibility and guilt when serving an abhorrent military regime.David C. Cassidy is the author of J. Robert Oppenheimer and the American Century, Einstein and Our World, and Uncertainty.