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Pediatric and Adult Coeliac Disease: A Clinically Oriented Perspective provides an up-to-date, comprehensive, and critical overview of coeliac disease, its complications, and related disorders. The book covers epidemiological, pathogenetic, diagnostic, and treatment issues, including pediatric and adult cases, with a broad and international view. This is the perfect reference for researchers dedicated to advancing the field of translational coeliac disease research as well as clinicians who are diagnosing and managing coeliac disease throughout all of its various stages.

Metaheuristics Algorithms for Medical Applications: Methods and Applications provides readers with the most complete reference for developing metaheuristics techniques with machine learning for solving biomedical problems. This book is organized to present a stepwise progression beginning with the basics of metaheuristics, leading into methods and practices, and concluding with advanced topics. The first section of this book presents the fundamental concepts of metaheuristics and machine learning and provides a comprehensive taxonomic view of metaheuristics methods according to a variety of criteria such as data type, scope, and method. The second section of this book explains how to apply metaheuristics techniques for solving large-scale biomedical problems, including analysis and validation under different strategies. The final portion of the book focuses on advanced topics in metaheuristics in four different applications. Readers will discover a variety of new methods, approaches, and techniques, as well as a wide range of applications demonstrating key concepts in metaheuristics for biomedical science. This book provides a leading-edge resource for researchers in a variety of scientific fields who are interested in metaheuristics, including mathematics, biomedical engineering, computer science, biological sciences, and clinicians in medical practice.

Beneficial Microbes for Sustainable Agriculture under Abiotic Stress: Functional Traits and Regulation highlights the potential for microbe-mediated stress phytotolerance to be improved by presenting multiple scenarios of application and results. In most research and studies, abiotic stress is applied singularly to specific plants inoculated with a bioinoculum or a microbial consortium to isolate specific plant-microbe responses. However, in reality, plants are continually exposed to a multitude of different stresses simultaneously occurring. This book presents microbial functional traits and microbe-mediated plant responses under both specific or combined stress conditions. Collectively, it provides insights into microbial functional traits and microbe-mediated plant responses in a wide range of conditions, providing foundational understanding of their potential benefits, and inspiring further research. The book also centers on specific microbial strains and groups which have been shown to effectively promote stress tolerance, and which could be utilized to boost agricultural production under stress conditions. Their potential utilization in stress affected lands not just improves crop production but could also be in line with sustainable agriculture. With the advancement of tools such as omics related technologies, emerging information on microbial functional traits and regulations on microbe-mediated phytotolerance will also allow us to develop relevant biotechnologies harnessing potentials of plant-microbe interactions under stress conditions. The information in this volume will be of interest to those working toward these next steps.

Biochemical Immunology of Diabetes and Associated Complications offers in-depth coverage of the association of biochemical and immunological aspects of the human body in diabetes. It discusses the suppression and modulation of the immune system and the impact of immunochemicals on the biochemical pathways in diabetes, along with associated complications. The book enumerates the exigency in knowledge about the immunomodulators as therapeutic targets to cure the syndrome. It will serve as an important reference for medical practitioners, researchers, medical students, masters and doctoral students. In addition, it could also be used as a reference for science graduates, science teachers, and researchers.

Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered.

Mite-Human Interactions: Nuisances, Vectors, Parasites, Allergens, and Commensals offers coverage on the neglected topic of mites, their diversity, and the conditions caused or vectored by them. The first part of the book differentiates the types of mites as arthropod-borne infectious disease vectors (scrub typhus, rickettsialpox), as bothersome pests (animal and itch mites), as potential allergens (dust and food mites), and as human commensals (follicle mites). The book further provides information on how to diagnose and treat mite-borne infections, infestations, and allergies and recommends ways to prevent and control them. In addition, the book also delves into topics such as the potential psychological impact of mites with the unusual condition of delusional parasitosis, also known as known as Morgellons disease and addresses the socioeconomic disparity issues in infections, infestations, and mite-associated conditions.

Development of Gluten-Free Pasta summarizes current progress in the development of gluten-free (GF) products, focusing particularly on pasta products. Presented in 11 chapters, the book focuses on the role of prebiotic fiber, hydrocolloids, fruit and vegetable by-product pomace and the physical, microstructural, sensory, and nutritional properties of the gluten-free pasta. The science of gluten intolerance is explained as well, with all relevant literature gathered and summarized in one place. Hence, this book lays a very solid foundation for the development of GF pasta which can be exploited as an essential therapeutic tool in the prevention of celiac disease. This comprehensive reference, written by world renowned scientists who elaborate on the study of different selected additives of plant origin, provides immense assistance in the field of research as many areas are still unexplored in the field of cereal science & technology.

Alzheimer's Disease and Advanced Drug Delivery Strategies compiles under a single volume the most recent advances in drug delivery to the brain as related to AD treatment. The book's editors recruited scientists from around the world to produce high quality chapters covering not only nanotechnological approaches, but also microsphere, niosomes, and liposomes. Among the topics covered are synthetic molecules, nobiletin, nose to brain delivery, natural biomaterials, cationic nanoformulations, dendrimers, microbubbles, and more. This book represents a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the brain.

Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity.

Dysphagia: A Clinical Guide will help practitioners and surgeons learn and understand how best to diagnose and treat dysphagia. It provides a complete picture of dysphagia through the experiences of leaders who cover the latest techniques and evidence-based outcomes in the field. Coverage includes recent advances in the diagnosis and treatment of the disease processes that cause dysphagia, gastric problems, and surgical intervention. The book includes the latest research and perspectives from both gastroenterologists and surgeons to enable clinicians to stay up-to-date on the most current and effective management strategies. Each chapter provides summary statements and recommendations based on recent literature. Recent discoveries regarding the diagnosis and management of dysphagia are exemplified by illustrations of both diagnostic methods and descriptions of interventional techniques. This an important reference for general surgeons, general practitioners, and ENT surgeons while also bringing new data dedicated specifically to gastroenterologists and foregut surgeons.

Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This two volume set is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection. Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This set provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease.

Integrative Omics: Concept, Methodology and Application provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference provides systemic 'step-by-step' coverage that begins with basic concepts from Omic to Multi Integrative Omics approaches followed by applications and emerging and future trends. All areas of Omics are covered, including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics, technology policy, and society research. This book covers recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science.

Therapy Resistance in Prostate Cancer: Mechanisms and Insights, Volume 20 highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and therapies that can be proposed to overcome resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide, as well as one of the most common causes of cancer-related deaths.Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.

Colorectal Cancer: Disease and Advanced Drug Delivery Strategies examines the combined impact of basic clinical and medical treatments as well as recent advances in the field of colorectal cancer. With a strong focus towards colorectal cancer diagnosis, disease drug delivery, and diagnosis, the book also examines the Tumor microenvironment-responsive and site-specific nanoparticles for cancer theragnostics. Sections provide the opportunity to understand and diagnose the disease, describes screening methods, and update on drugs, including nano- and immunotherapy. Content includes clinical trials in colorectal cancer research and disease models that help better direct researchers and clinicians on how to diagnose and treat colorectal cancer.

Progress in Motor Control: From Neuroscience to Patient Outcomes updates the state-of-the-art of knowledge among scientists on basic and applied research on control of movements of biological systems through a clinical perspective. Motor control is a scientific area characterized by multidisciplinary approaches. This book promotes the application of this area into clinical practice. Chapters focus on topics in the field of motor control, including neural control of goal-oriented action, theories on rules of interaction during motor learning, and action coordination up to human and machine interaction.Edited by experts in the field, this book translates current theoretical outcomes into neuroscience and therapeutic solutions.

¿¿ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical ¿¿ T cell immunotherapy landscape.In five chapters, field experts discuss the challenges facing ¿¿ T cell oncoimmunotherapy, propose solutions, and map next steps.Particular attention is given to summarizing our understanding of the complex, translationally relevant human ¿¿ T cell biology, the evidence basis for designing ¿¿ T cell combination trials and data-driven perspectives on what is known-and what isn’t-about ¿¿ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering.A chapter is dedicated to the systematic review of all ¿¿ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of ¿¿ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering.¿¿ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of ¿¿T cell immunotherapy, which is of interest to existing translational ¿¿ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter ¿¿ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

The prolific deployment of Artificial Intelligence (AI) across different fields has introduced novel challenges for AI developers and researchers. AI is permeating decision making for the masses, and its applications range from self-driving automobiles to financial loan approvals. With AI making decisions that have ethical implications, responsibilities are now being pushed to AI designers who may be far-removed from how, where, and when these ethical decisions occur. Trolley Crash: Approaching Key Metrics for Ethical AI Practitioners, Researchers, and Policy Makers provides audiences with a catalogue of perspectives and methodologies from the latest research in ethical computing. This work integrates philosophical and computational approaches into a unified framework for ethical reasoning in the current AI landscape, specifically focusing on approaches for developing metrics. Written for AI researchers, ethicists, computer scientists, software engineers, operations researchers, and autonomous systems designers and developers, Trolley Crash will be a welcome reference for those who wish to better understand metrics for ethical reasoning in autonomous systems and related computational applications.

Carbon-Based Nanomaterials in Biosystems: Biophysical interface at Lower Dimensions provides a thoroughly comprehensive overview of all major aspects of carbon-based nanomaterials, their biophysical response, and biotechnological applications. The book articulates the underlying physics, chemistry, and the basic phenomenon of the broad-range carbon-based nanomaterials (CNMs) with biological systems, particularly the interface analysis. Organized in six sections, it discusses state-of art technological interventions of carbon-based nanomaterials and their application in biomedical sectors in healthcare, food sciences, and technology. The book also highlights the carrying capacity of different CNMs in payload efficiency mechanisms in various biomedical fields. The theranostic efficiency and the safety of various forms of CNMs is assessed. This book will be a helpful resource to those specializing in the areas of nanomedicine, bionanomaterials, and nanotechnology applications.

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA.

Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible. With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits. This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade.

Strigolactones: Synthesis, Application and Role in Plants presents the current state of the science for this recently discovered class of plant hormones, offering foundational insights. The book covers the structure of natural and synthetic SLs, synthesis, transport, signaling, and their application, role in the growth and development of plants like seed germination, root growth, and stem branching plant architecture. Further, the crosstalk of SLs with other plant hormones and signaling molecules are discussed. Finally, the role of SLs in plant defense systems, particularly in biotic and abiotic stresses, heavy metals, salt, temperature, radiation, pesticide drought, and flood stress on plants.Concluding with the latest discoveries, future perspectives, and challenges in plant biology, this book will be a valuable reference for those in plant and agricultural sciences.

Globalization creates economic prosperity for citizens around the world. It changes people’s deep-rooted attitudes, values, and behavioral patterns. Editor Thomas Li-Ping Tang is the first to scientifically capture the meaning of money and coin the contemporary love of money construct. Ardent monetary aspirations involve affective, behavioral, and cognitive subconstructs. Monetary Wisdom: Monetary Aspirations Impact Decision-Making bridges the gaps between behavioral economics, business ethics, decision-making, and the psychology of money. It compiles research from world-renowned experts in 37 countries across 6 continents. This book presents an excellent collection of innovative and multicultural views. Monetary Wisdom investigates how individuals apply monetary aspirations as a lens, frame critical concerns at the proximal and omnibus contexts, and maximize expected utility and ultimate serenity at the individual, organizational, and global levels. The books’ practical implications help readers apply and enjoy these discoveries’ benefits.

Picture Fuzzy Logic and Its Applications in Decision Making Problems provides methodological frameworks and the latest empirical research findings in the field of picture fuzzy operators and their applications in scientific research and real-world engineering problems. In this book, picture fuzzy sets are investigated, and different types of operators are defined to solve a number of important decision-making and optimization problems. The hybrid operator on picture fuzzy set based on the combination of picture fuzzy weighted averaging operators and picture fuzzy weighted geometric operators is developed and named Hybrid Picture Fuzzy Weighted Averaging Geometric (H-PFWAG) operator. In addition, another operator is developed for interval-valued picture fuzzy environment, which is named Hybrid Interval-Valued Picture Fuzzy Weighted Averaging Geometric (H-IVPFWAG) operator. These two operators are then demonstrated as solutions to Multiple-Attribute Decision-Making (MADM) problems. The picture fuzzy soft weighted aggregation operators (averaging and geometric) are defined, and these are applied to develop a multi-criteria group decision making system.

Transglutaminase: Fundamentals and Applications, a new volume in the Foundations and Frontiers in Enzymology series, stands as a comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field, international experts discuss basic biology and structure - function relationships of transglutaminases, ongoing fundamental research, and new application areas, including food processing, material synthesis, biomedicine, disease treatment, and biotechnology. Approaches for sourcing transglutaminases from animals, plants, and microorganisms are considered, followed by chapters on applied uses in biomedicine, skin, bone biology, medicine, drug development, tissue engineering, seafood bioprocessing, dairy bioprocessing, synthesis of materials and polymers, and as an immobilization agent.Research protocols are also provided, including research rationale, design, substrates, assays, and microassay steps for studying transglutaminases.