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Emery and Rimoin¿s Principles and Practice of Medical Genetics and Genomics: Developmental Disorders, Seventh Edition is distinguished as the ultimate resource for clinicians integrating genetics into medical practice. This updated edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications in medicine more broadly. Users will find comprehensive sections on medical genetics applied to a range of developmental disorders and an emphasis on understanding the genetic mechanisms underlying these disorders, diagnostic approaches, and therapeutics that make use of current genomic technologies and translational studies. Updated chapters on human developmental genetics as well as the genetics of sexual development, clefting, dental, and craniofacial syndromes, craniosynostosis, rasopathies, sex-chromosome abnormalities, and autosomal deletions, among other disorders are included.

Anatomy of Neuropsychiatry: The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness, Second Edition presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. The book discusses the limbic system¿the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory¿and how this is no longer a useful guide to psychiatric disorders. Newly revised, this book now includes chapters focusing on the anatomy of Basal Forebrain and Cerebellum Macrosystems and the role these macrosystems play in motion, emotion, and neuropsychiatric illnesses.This book will help reader develop an understanding of the gross anatomical organization of the human forebrain.

Introduction to Protein Mass Spectrometry, Second Edition provides a comprehensive overview of this increasingly important, yet complex, analytical technique. This book enables readers to understand how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. This new edition is fully updated to include the latest developments in the field and will feature new content covering recent progress in the areas where there have been the most exciting advances. These include PNNL¿s multilevel-PCB-based SLIM realization, SLIM-Agilent QQQ field trials; employment of SLIM-IMS-cryo-IR combination in molecular structure determination; proximity-labelling mass spectrometry, and applications in neuroscience.

Bacterial Biogeochemistry: The Ecophysiology of Mineral Cycling, Fourth Edition discusses the influence of bacterial activity on the chemical environment of the biosphere. Following the success of previous editions, this update focuses on bacterial metabolism and its relevance to the environment, including the decomposition of soil, food chains, nitrogen fixation, assimilation, and reduction of carbon nitrogen and sulfur, and microbial symbiosis. All chapters have been revised and brought up-to-date in light of the many advances and discoveries that have taken place during the last decade. The scope of the new edition has broadened to provide a review of the processes and phenomena that are relevant for global change feedback loops and advances in bacterial biogeochemical cycles.

Dynamic Aquaria: Building and Restoring Ecosystems and the Biosphere, Fourth Edition demonstrates how the living systems modeling of aquatic ecosystems for ecological, biological, physiological research, and ecosystem restoration produce answers to very complex ecological questions. The book describes unique characteristics of water that have allowed carbon chemistry to flourish and evolve life over 4 billion years, along with current disruptions such as global warming, overfishing, and chemical pollution. New content in this edition includes the use of LED lighting, DNA sequencing in microcosm construction and analysis, and the expansion of the bioengineered tool Algal Turf Scrubbing (ATS) to combat global pollution problems.The book also features new information on marine calcification, research microcosms, thermogeography, and methods of water movement for minimizing plankton loss. It supports a deeper biological and ecological intelligence among the human population to better understand the processes behind environmental issues.

Handbook of Proteolytic Enzymes, Metallopeptidases has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes. This volume includes over 300 chapters on known metallopeptidases enzymes, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Soil Microbiology, Ecology, and Biochemistry, Fifth Edition addresses the increasingly important field of soil biota and their interactions in research and education. Soil biota are extremely important, and especially relevant to today¿s societal questions related to global change, ecosystem sustainability, and food security in our ever-changing environment. Revised by a group of world-renowned authors in many institutions and disciplines, this book relates breakthroughs in knowledge in this important field, along with its history and future applications. This new edition provides readable, practical, impactful information for many applied and fundamental disciplines. There is no other available volume on the topics covered that also integrates the concepts in a way that makes them useful to a broad group of readers.

Geophysical Data Analysis and Inverse Theory with MATLAB or Python, Fifth Edition is a revised and expanded introduction to inverse theory and tomography as it is practiced by geophysicists. The book demonstrates the methods needed to analyze a broad spectrum of geophysical datasets, with special attention given to those methods that generate images of the earth. Data analysis can be a mathematically complex activity, but the treatment in this volume is carefully designed to emphasize those mathematical techniques that readers will find the most familiar and to systematically introduce less-familiar ones. A series of "crib sheets" offer step-by-step summaries of methods presented. Utilizing problems and case studies, along with MATLAB and Python computer code and summaries of methods, the book provides professional geophysicists, students, data scientists and engineers in geophysics with the tools necessary to understand and apply mathematical techniques and inverse theory.

The Microbiology, Pathogenesis, and Zoonosis of Milk Borne Diseases offers comprehensive coverage of milk-borne infection, diagnosis, and treatment. With a strong focus on milk hygiene, zoonotic diseases, and the pathogenesis of milk-borne microbial agents, this book discusses various pathogenic diseases, evaluates the severity of diseases from milk and milk products, and describes remedial measures after the application of drugs.This book also introduces the reader to the microbiology, pathogenesis, and zoonosis of milk-borne diseases. It not only describes the general aspects of milk-borne zoonosis and prevention, but also covers risk analysis, assessment, practice, and quality management in milk hygiene.In 22 chapters, The Microbiology, Pathogenesis, and Zoonosis of Milk Borne Diseases provides researchers, academicians, industry professionals, and students with a better understanding on how to assess zoonotic diseases from milk-borne pathogens and address their clinical manifestations.

Our Genes, Our Choices: How Genotype and Gene Interactions Affect Behavior, Second Edition explains how the complexity of human behavior, including concepts of free will, derives from a relatively small number of genes, which direct neurodevelopmental sequences. Are people free to make choices or do genes determine behavior? Paradoxically, the answer to both questions is "yes," because of neurogenetic individuality, a new theory with profound implications. Here, author David Goldman uses judicial, political, medical, and ethical examples to illustrate that this lifelong process is guided by individual genotype, molecular and physiologic principles, as well as by randomness and environmental exposures. Written in an authoritative yet accessible style, the book includes practical descriptions of the function of DNA, discusses the scientific and historical bases of genethics, and introduces the topics of epigenetics and the predictive power of behavioral genetics.

Data Fusion Techniques and Applications for Smart Healthcare covers cutting-edge research from both academia and industry, with a particular emphasis on recent advances in algorithms and applications that involve combining multiple sources of medical information. The book can be used as a reference for practicing engineers, scientists, and researchers, but it will also be useful for graduate students and practitioners from government and industry as well as healthcare technology professionals working on state-of-the-art information fusion solutions for healthcare applications. Medical data exists in several formats, from structured data and medical reports to 1D signals, 2D images, 3D volumes, or even higher dimensional data such as temporal 3D sequences. Healthcare experts can make auscultation reports in text format; electrocardiograms can be printed in time series format, X-rays saved as images; volume can be provided through angiography; temporal information by echocardiograms, and 4D information extracted through flow MRI.

Deep Learning Applications in Translational Bioinformatics, a new volume in the Advances in Ubiquitous Sensing Application for Healthcare series, offers a detailed overview of basic bioinformatics, deep learning, and various applications of deep learning in translational bioinformatics, including deep learning ensembles, deep learning in protein classification, detection of various diseases, prediction of antiviral peptides, identification of antibiotic resistance, computer aided drug design and drug formulation. This new volume helps researchers working in the field of machine learning and bioinformatics foster future research and development.

Introduction to Plasmas and Plasma Dynamics: With Plasma Physics Applications to Space Propulsion, Second Edition provides an accessible introduction to the understanding of the high temperature, ionized gases necessary to conduct research and develop applications related to plasmas. Thoroughly updated and expanded, this second edition is also amended for greater ease of use with the inclusion of self-study problems. New chapters addressing numerical methods in plasmas, the kinetic description and analysis of plasma, and the chemistry of the ionosphere open up this subject to a broader range of readers. Starting with the essential theory, this book goes on to describe relevant devices and mechanisms, before presenting a clear outline of the analysis and numerical details of plasma. The latest trends, concepts, and applications in plasma engineering are also addressed, including plasma formation and magnetic fusion, plasma thrusters and space propulsion.

The New Public Health has established itself as a solid textbook throughout the world. Translated into seven languages, this work distinguishes itself from other public health textbooks, which are either highly locally oriented or, if international, lack the specificity of local issues relevant to students' understanding of applied public health in their own setting. Fully revised, The New Public Health, Fourth Edition provides a unified approach to public health appropriate for graduate students and advance undergraduate students especially for courses in MPH, community health, preventive medicine, community health education programs, community health nursing programs. It is also a valuable resource for health professionals requiring an overview of public health.

Water-Soil-Vegetation Nexus and Climate Change presents an overview of research needs and approaches regarding water-soil-vegetation nexus and climate change. The book includes chapters discussing water budget and factors that affect hydrologic processes such as precipitation, runoff, infiltration, evapotranspiration, soil water, and groundwater, in addition to a focus on consumptive (e.g., domestic and irrigation) and non-consumptive (e.g., eco-environmental) water uses, and water shortage. Throughout the book, chapters specifically deal with the fundamental principles and also case studies, applications, and decision support tools that can be usable for developing practical management measures in sustaining our eco-environment and society by maintaining an optimal water-soil-vegetation equilibrium. Written with water resources students and professors in mind, this book will provide the reader with further knowledge on the water-soil-vegetation nexus and its connection to climate change.

Handbook of Social Media Use: Online Relationships, Security, Privacy, and Society explores the determinants of social media use in individuals. This book investigates the ways in which individuals use social media to engage with their social world. This multi-contributed book also discusses the challenges and individual and social risks that may arise from social media, including addiction. Social media platforms provide us with opportunities to engage in our social worlds in ways that are unprecedented. Social media enhances and transforms how we interact with our social world, both online and offline. With this increase in available individual information and interconnectedness, new avenues for the exploitation and influences of individuals are discovered, hence this book is an ideal resource on the topics covered.