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Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.--Publisher's website.

Nanometal Oxides in Horticulture and Agronomy, a volume in the Nanomaterial-Plant Interactions series, summarizes the physiological, morphological, biochemical, and molecular regulation of metal oxide nanoparticles in plants under normal conditions as well as during different stresses. With a focus on impact and applications, it presents the latest advances in the roles of metal oxide nanoparticles in both horticulture and agriculture. Metal oxide nanoparticles have been reported as beneficial inorganic materials for the growth and development of plants, playing a protective role against the abiotic and biotic stresses. Researchers need to understand the different regulatory pathways of metal oxide nanoparticles, including their mechanisms of operation under different stressful conditions. This volume presents the physiological, morphological, biochemical, and molecular regulation of metal oxide nanoparticles in plants in normal conditions as well as during different stresses. It also discusses tolerance mechanisms and the variety of roles and applications that metal oxide nanoparticles have within plant biology. Beginning with an introductory overview to metal oxide nanomaterials, chapters discuss the effect of metal oxide nanomaterials on biochemical pathways within the plant, highlighting key applications such as fertilizers, weed control systems and pest control systems. It describes the impact of metal oxide nanoparticles in different challenging environmental conditions. Concluding with a discussion of the strengths and weaknesses of metal oxide nanoparticles in agriculture, Nanometal Oxides in Horticulture and Agronomy provides inspiration for further research and advancement. This book is an essential read for researchers and students interested in horticulture, agronomy, and plant nanomaterials.

Food Sustainability and the Media: Linking Awareness, Knowledge and Action is the first book to explore the roles that the media plays in raising awareness, spurring action, and increasing understanding about food security and global sustainability issues. The book addresses the means of leveraging traditional and new media to advance food and sustainability discourse by linking awareness, knowledge, and action. The book links sustainability and food security in media communication to address different topics, including the way climate change is framed by the media, key factors of success and failure in NGOs, public and corporate communication, and climate change denial.

Translational Surgery covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control studies, prospective cohort studies, randomized trials, and reliability studies. Investigators will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in surgical research, and know what is needed for collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the translational research navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in surgery, allowing the reader to learn how to evaluate the quality of such studies. Thus, they will improve at measuring outcomes; making effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every surgeon or surgical researcher who has ever had a good clinical idea, but not the knowledge of how to test it.

Psychophysics and Experimental Phenomenology of Pattern Cognition examines the cognitive transformations that underly this cognitive system and the specialized subsystems for processing these transformations. Sections cover symmetry cognition, contour perception and geometric illusion. Weight sensation is also discussed, as are repetitive and dot patterns. By incorporating elements of both psychophysics and experimental phenomenology, pattern cognition is examined from both the physical and mental sensory perspective, thus providing a comprehensive view of this cognitive system.

Fundamentals of Viroid Biology provides a comprehensive introduction to emerging research on viroids and their biology. The book is organized into three parts, with sections that discuss historical perspectives as well as information on classifications, structure, life cycle and replication and viroid movement. The book goes on to discuss viroid diseases and their geographic distributions across Asia, Europe, Africa, Australia, North and South America. Viroid pathogenesis and viroid-host interaction rounds out the coverage which includes viroid associated disease symptoms and viroid regions associated and viroid-host protein and translations. Detection and disease control strategies are also covered. Contributed by an international group of renown contributors in viroid research, this book is a useful introductory reference to advanced undergraduates and graduate and postgraduate students. It is also ideal for early career researchers and scientists engaged in the study of viroid biology, virology, plant virology and microbiology.

Artificial Intelligence in Capsule Endoscopy: A Gamechanger for a Groundbreaking Technique highlights the importance of Artificial Intelligence (AI) application in capsule endoscopy. AI will have a key role in the mid/long-term for gastrointestinal endoscopy and capsule endoscopy. This field is a prime area for the use of AI tools with over 50,000 images per endoscopy capsule video, making video analysis a time and resource consuming task and prone to error. With the application of AI image analysis tools (primarily Convolutional Neural Networks) we can decrease capsule endoscopy video reading time and resources and greatly benefit diagnostic accuracy and patient outcomes. In 15 chapters, this important reference provides a global and comprehensive perspective from the background information of AI, machine learning, deep learning and their implications in GI endoscopy. It showcases AI practical use in lesion detection and in relevant clinical indications (like obscure gastrointestinal bleeding and inflammatory bowel disease), and points to future applications of AI within the field.

Personal Care Products and Human Health provides background, historical context and the latest research results on personal care products (PCPs) and their impact on human health and the environment. Sections provide an overview of the functions and mechanisms of action of components of personal care products, discuss environmental toxicology, outline the problems of contamination of water systems from increasing use of personal care products and the resulting toxicities to aquatic wildlife, and offer chapters written by specialists on different aspects of concern for the effects of excessive personal care product usage on human health. This is a comprehensive reference for toxicologists, environment scientists and those interested in learning about the science behind personal care products and current concerns for environmental and human health.

Computational Intelligence for Medical Internet of Things (MIoT) Applications: Machine Intelligence Applications for IoT in Healthcare explores machine intelligence techniques necessary for effective MIoT research and practice, taking a practical approach for practitioners and students entering the field. This book investigates advanced concepts and applications in the MIoT field, guiding readers through emerging developments and future trends. A wide range of international authors guide readers through advanced concepts, including deep learning, neural network, and big data analytic approaches for the classification, indexing, retrieval, analysis, and inferencing of healthcare data.

Cognitive Intelligence with Neutrosophic Statistics in Bioinformatics investigates and presents the many applications that have arisen in the last ten years using neutrosophic statistics in bioinformatics, medicine, agriculture and cognitive science. This book will be very useful to the scientific community, appealing to audiences interested in fuzzy, vague concepts from which uncertain data are collected, including academic researchers, practicing engineers and graduate students. Neutrosophic statistics is a generalization of classical statistics. In classical statistics, the data is known, formed by crisp numbers. In comparison, data in neutrosophic statistics has some indeterminacy. This data may be ambiguous, vague, imprecise, incomplete, and even unknown. Neutrosophic statistics refers to a set of data, such that the data or a part of it are indeterminate in some degree, and to methods used to analyze the data.

Indigenous Fermented Foods for the Tropics provides insights on fermented foods of the Tropics, particularly Africa, Asia and South America, highlighting key aspects and potential developments for these food products. Sections provide an overview on the production and composition (nutritional, physicochemical, health beneficial and microbiota) of these indigenous fermented foods in the tropics, innovative techniques for investigating the composition of these fermented food products and improvement of the fermentation process to yield better nutritional constituents, health beneficial components and sensory qualities, and safety aspects to be considered in fermented foods. Other sections provide insights into the packaging and marketing of these food products as well as future prospects of fermented foods in the tropics. This book provides new perspectives and recent information to complement existing texts on indigenous fermented foods serving as a valuable reference text for detailed insights into indigenous fermented foods of the tropics.

Diagnostic Biomedical Signal and Image Processing Applications with Deep Learning Methods presents comprehensive research on both medical imaging and medical signals analysis. The book discusses classification, segmentation, detection, tracking and retrieval applications of non-invasive methods such as EEG, ECG, EMG, MRI, fMRI, CT and X-RAY, amongst others. These image and signal modalities include real challenges that are the main themes that medical imaging and medical signal processing researchers focus on today. The book also emphasizes removing noise and specifying dataset key properties, with each chapter containing details of one of the medical imaging or medical signal modalities. Focusing on solving real medical problems using new deep learning and CNN approaches, this book will appeal to research scholars, graduate students, faculty members, R&D engineers, and biomedical engineers who want to learn how medical signals and images play an important role in the early diagnosis and treatment of diseases.

Berry Bioactive Compound By-Products explores the phytochemistry, functional properties, health-promoting effects, and food and non-food applications of bioactive compounds in berry processing by-products. The book covers a range of berry processing by-products, including mulberry, raspberry, blueberry, and many more. The book examines the chemical composition, bioactive compounds, green methods for extraction, metabolism and bioactivity of bioactive components, biorefinery, bioenergy, and zero waste processing, and economic values for each berry's by-products. Edited by world experts, this book is a valuable resource for food scientists, researchers, and students in the fields of functional foods and food science, technology, and bioprocess engineering.

Ophthalmic Pathology: The Evolution of Current Concepts examines how our current understanding of morphologic disease, nomenclature and classification over the last century came about. The book explores the historical context and the modern trends of ocular nosology, emphasizing the science of disease classification. Chapters highlight major studies and developments surrounding approximately 50 disorders whose diagnoses are established by pathology, corresponding to a historical road map of current nomenclature, methods of disease classification, and the role of diagnostic morphology. Using a streamlined, highly illustrated format, this book provides a unique historic and evolutionary perspective into current views on the morphology of eye disease.

Studies on integer optimization in emergency management have attracted engineers and scientists from various disciplines such as management, mathematics, computer science, and other fields. Although there are a large number of literature reports on integer planning and emergency events, few books systematically explain the combination of the two. Researchers need a clear and thorough presentation of the theory and application of integer programming methods for emergency management. Integer Optimization and its Computation in Emergency Management investigates the computation theory of integer optimization, developing integer programming methods for emergency management and explores related practical applications. Pursuing a holistic approach, this book establishes a fundamental framework for this topic, intended for graduate students who are interested in operations research and optimization, researchers investigating emergency management, and algorithm design engineers working on integer programming or other optimization applications.

Clinical Management of Pediatric COVID-19: An International Perspective and Practical Guide provides the most current international research and clinical characteristics of pediatric patients with SARS-CoV-2 infection. Coverage ranges from epidemiology including origin, route of transmission, incubation period, mortality and susceptibility risk factors; to pathogenesis, including difference between the adult and pediatric populations. Diagnosis is covered with special attention to the difference between adult and pediatric patients as well as the differences between newborns, children and adolescents. The book presents current complications, including multisystemic inflammatory syndrome as well as treatment therapies including antiviral and immunomodulatory therapies for this age group. Finally, immunization efficacy and safety are examined. This is the perfect reference to provide guidance to pediatricians on the diagnosis and treatment of SARS-CoV-2, as well as a valuable source of the latest research about the pediatric population for further study.

The Transgender Athlete: A Guide for Sports Medicine Providers presents sports medicine practitioners insights into the unique issues and concerns of transgender athletes in order to help them understand rules regarding transgender athlete participation and learn how to better provide competent care to transgender athletes. There are over 1.4 million transgender adults in the United States. Transgender individuals undergo gender-affirming treatments including sex hormone therapy and gender-affirming surgery. An increasing number of transgender people are participating in sports and presenting to sports medicine clinics with injuries, yet there is little research about this athlete population. It is important that sports medicine providers understand the types of hormone treatments and surgeries and how these changes affect the musculoskeletal health of transgender people. Additionally, transgender people may require specific considerations when interacting with medical providers. Furthermore, sports medicine providers are often consulted to formulate transgender athlete inclusion policy. These policies are continuously changing, as new evidence becomes available, which may be difficult to understand without knowledge of the gender transition process.

Value Addition in Agri-Food Industry Waste through Enzyme Technology, Volume Three explores advances in the production of high value-added products from agri-food industry waste/residues using enzyme technology. Waste materials used in hydrogen production are categorized as agricultural waste, municipal waste, industrial waste, and other hazardous wastes. The book explores advances in value-addition to waste materials and includes utilization of industrial, agricultural and municipal waste for its bioconversion using enzyme technology. This book assembles the novel sources and technologies involved in value-added products formation from specific waste materials, making it an essential reference to professionals, scientists, and academics in agri-food and related industries.

The field of Assisted Reproductive Technology (ART) is rapidly evolving and stimulation protocols, fertility strategies and aspects of infertility treatments are constantly being updated as advances and new discoveries are made. Handbook of Current and Novel Protocols for the Treatment of Infertility is a valuable resource of well-organized, comprehensive scientific data with practical guides and step-by-step protocols for infertility management. Written by world-wide experts, this book discusses different practice patterns and approaches used internationally and presents innovative topics including preimplantation genetic testing, time lapse imaging and the role of artificial intelligence in ART. This book provides up-to-date, evidence-based guidance on daily practice and is an important resource for infertility providers, including trainees or experienced clinicians, embryologist, and is geared for both specialist in reproductive medicine and gynecologists interested in increasing their knowledge in the field of reproductive endocrinology and intertility.

Endophytic Association: What, Why, and How focuses on the endophytic association of plants, how they have originated inside the host, their importance, and how they are beneficial for the environment, as well as humans. The book discusses how using endophytic microbes in agricultural fields can be enriched without impacting environment negatively, and how they can be utilized for pharmaceutical purposes, including bioremediation. It includes advanced and up-to-date information, as well as future directions for young researchers and scientists who are working in the field of agriculture, pharmaceuticals, bio nanotechnology and bioremediation of environmental contaminants for environmental protection and sustainable development.

Interactions of Bone with Orthopedic Implants and Possible Failures focuses on the mechanical and biological issues that may cause failure of the implant-bone construct. The book provides discussions on the effects of the design, process, surface and other engineering parameters of implants and their interaction with bone tissue. For implant designers, it is highly crucial to know the final effects of what they are designing or aiming to design, along with performance parameters. It is also crucial for orthopedic surgeons to be familiar with the background of the design and process parameters of the implant they will insert in a patient's body. With the understanding brought forth in this book, surgeons can have better implant options and implant designers can create and develop new implant designs. This book can also help biomechanical and mechanical engineers who are normally dealing with testing and analysis of orthopedic implants examine the biomechanical behavior of the implants and their interaction with bone tissue.

Synergistic Approaches for Bioremediation of Environmental Pollutants: Recent Advances and Challenges focuses on the exploitation of various biological treatment technologies and their use to treat toxic contaminants present in industrial effluent and in restoring contaminated sites, which lacks in a more comprehensive manner in existing titles on similar topics available on the global market. The book comprises advanced biotechnologies and updated information, along with sustainable waste management developments and future directions for researchers and scientists working in the field of microbiology.

Fast Satellite Attitude Maneuver and Control introduces the concept of agile satellites and corresponding fast maneuver attitude control systems, systematically and comprehensively presenting recent research results of fast maneuver attitude control for agile satellites by using advanced nonlinear control techniques. This reference book focuses on modeling and attitude control, considering different actuator combinations, actuator installation deviation, actuator fault, and flexible appendage coupling effect for agile satellites. The book provides a unified platform for understanding and applicability of agile satellites fast maneuverer and stabilization control for different purposes. It will be an excellent resource for researchers working on spacecraft design, nonlinear control systems, vehicle systems and complex control systems.

Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal infections. The book offers encouragement and empowers readers to re-embrace their knowledge of phytoconstituents and their various antifungal activities against most opportunistic pathogenic fungi as fungal diseases cause an estimated 1.5+ million deaths annually and over one billion people suffer from severe fungal disease. In this complex scenario, it is now clear that global warming and accompanying climate changes have resulted in increased incidence of many fungal infections. On the basis of all these factors, concerns on the occurrence of a pandemic fungal origin in the near future have been raised. In this context, to stop forgetting and underestimating fungal diseases is mandatory.