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Merging the benefits of two well-known methodologies, Lean Thinking and Total Productive Maintenance, this title shows how to secure increased manufacturing efficiency. It provides the tools and techniques that convert strategic vision into reality. It shows how to achieve zero breakdowns. It includes an integrated route map for Lean TPM.

Filters are used in many industries, especially the water, sewage, oil, gas, food and beverage, and pharmaceutical industries. This title is suitable for engineers working in a plant situation, who requires guidance and information on what is available and whether it is suitable for the job in hand.

Part one covers modeling techniques incorporating quantum mechanical effects to simulate nanomaterials and devices. Part two describes the characterization of nanomaterials using diffraction techniques and Raman spectroscopy. Part three looks at the structure and properties of nanomaterials. Part four explores nanofabrication and nanodevices.

Part one covers architectures for VCS, part two describes the physical layer, antenna technologies and propagation models, part three explores protocols, algorithms, routing and information dissemination and part four looks at the operation and deployment of vehicular communications and networks.

This book presents an authoritative overview of spent fuel reprocessing and considers future prospects for advanced closed fuel cycles.

This book provides a detailed overview of advanced water treatment methods involving membranes, which are increasingly seen as effective replacements for a range of conventional water treatment methods.

Wear of Polymers and Composites introduces fundamentals of polymers and composites tribology. This important new book suggests a new approach to explore the effect of applied load and surface defects on the fatigue wear behaviour of polymers, using a new tribometer and thorough experiments.

This book reviews the main materials used for food contact in terms of the global legislation in place to ensure their safe and effective use.

Welding and Joining of Advanced High Strength Steels (AHSS): The Automotive Industry discusses the ways advanced high strength steels (AHSS) are key to weight reduction in sectors such as automotive engineering. It includes a discussion on how welding can alter the microstructure in the heat affected zone, producing either excessive hardening or softening, and how these local changes create potential weaknesses that can lead to failure. . This text reviews the range of welding and other joining technologies for AHSS and how they can be best used to maximize the potential of AHSS.

Individualized cancer chemotherapy (ICC) has been designed to meet the requirement of selecting anticancer drugs in clinics and attracting increasing attentions in medical circle and will show more beneficial outcome in the future if we stick on these researches. Personalized Cancer Chemotherapy addresses and reviews this issue by discussing many existing specific strategies of ICC, including drug sensitivity testing, cancer biomarker detections, cancer biomarker-oriented therapy, anticancer drug pharmacogenetics, cancer metastasis therapy, anticancer drug combinations, assistant therapy, mathematics, and computational analysis of cancer malignancy and drug responses, cost effective and finally studies of relationship between different ICC strategies. The relationship between drug response and these techniques or methods is in-depth analyzed, discussed and highlight. Many longstanding key debates and future trends are also intensively discussed, highlighted and debuted with new twists.

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies.

This book critically reviews the fundamental principles, systems, oxygen carriers and carbon dioxide carriers relevant to chemical looping and combustion.

Annual Reports in Computational Chemistry provides timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists.

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

Respiration is one of the most basic motor activities crucial for survival of the individual. It is under total control of the central nervous system, which adjusts respiratory depth and frequency depending on the circumstances the individual finds itself. For this reason this volume not only reviews the basic control systems of respiration, located in the caudal brainstem, but also the higher brain regions, that change depth and frequency of respiration. Scientific knowledge of these systems is crucial for understanding the problems in the many patients suffering from respiratory failure.

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

R is open source statistical computing software. Since the R core group was formed in 1997, R has been extended by a very large number of packages with extensive documentation along with examples freely available on the internet. It offers a large number of statistical and numerical methods and graphical tools and visualization of extraordinarily high quality. R was recently ranked in 14th place by the Transparent Language Popularity Index and 6th as a scripting language, after PHP, Python, and Perl. The book is designed so that it can be used right away bynovices while appealing to experienced users as well.Each article begins with a data example that can be downloaded directly from the R website. Data analysis questions are articulated following the presentation of the data. The necessary R commands are spelled out and executed and the output is presented and discussed. Other examples of data sets with a different flavor and different set of commands but following the theme of the article are presented as well. Eachchapter predents a hands-on-experience. R has superb graphical outlays and the book brings out the essentials in this arena. The end user can benefit immensely by applying the graphics to enhance research findings. The core statistical methodologies such as regression, survival analysis, and discrete data are all covered.

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.