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Machine Learning: A Constraint-Based Approachprovides readers with a refreshing look at the basic models and algorithms of machine learning, with an emphasis on current topics of interest that includes neural networks and kernel machines. The book presents the information in a truly unified manner that is based on the notion of learning from environmental constraints. For example, most resources present regularization when discussing kernel machines, but only Gori demonstrates that regularization is also of great importance in neural nets. This book presents a simpler unified notion of regularization, which is strictly connected with the parsimony principle, and includes many solved exercises that are classified according to the Donald Knuth ranking of difficulty, which essentially consists of a mix of warm-up exercises that lead to deeper research problems. A software simulator is also included. Presents fundamental machine learning concepts, such as neural networks and kernel machines in a unified mannerProvides in-depth coverage of unsupervised and semi-supervised learningIncludes a software simulator for kernel machines and learning from constraints that also includes exercises to facilitate learningContains 250 solved examples and exercises chosen particularly for their progression of difficulty from simple to complex

Cases in Laboratory Genetics and Genomics (LGG) Practice instructs readers in the lab-based diagnosis of genetic conditions, including inborn and acquired disorders using cytogenetics and molecular genetics technologies. This entirely case-based book covers a wide range of genetic cases, from prenatal to postnatal and oncology genetic disorders which lab professionals and geneticists encounter daily in the diagnostic field. Each disorder discussed includes a section on clinical background, clinical indication, tests ordered, laboratory tests performed, test results, results with interpretations, future testing and recommendations, and references. The book will help lab professionals understand and navigate clinical cases using an integrative approach, and thoroughly understand the methodologies and interpretations involved in high complexity genetic testing.

Nuclear Decommissioning Case Studies: Characterization, Waste Management, Reuse and Recycle, Author's Statement on the Sustainability of Nuclear Decommissioning, Volume Six presents a selection of global case studies that focus on a range of technologies for the decontamination, dismantling, spent fuel treatment and recycling of nuclear decommissioning. The book presents best practices by analyzing errors and inadequacies, leading the reader to sound decision-making. The events covered in this publication range from national and local legislation, to regulatory positions, statements or recommendations, licensing steps and transition phases. Decommissioning experts, including regulators, operators, waste managers, researchers and academics will find this book to be suitable supplementary material to Michele Laraia's reference works on the theory and applications of nuclear decommissioning. Alongside the other case studies books in this series, readers will obtain an understanding of various key case studies-what happened and what we can learn from them, to help supplement, solidify and strengthen their understanding of the topic.

Principles of Soil and Plant Water Relations, Third Edition describes the fundamental principles of soil and water relationships in relation to water storage in soil and water uptake by plants. The book explains why it is important to know about soil-plant-water relations, with subsequent chapters providing the definition of all physical units and the SI system and dealing with the structure of water and its special properties. Final sections explain the structure of plants and the mechanisms behind their interrelationships, especially the mechanism of water uptake and water flow within plants and how to assess parameters. All chapters begin with a brief paragraph about why the topic is important and include all formulas necessary to calculate respective parameters. This third edition includes a new chapter on water relations of plants and soils in space as well as textbook problems and answers.

Microfluidics-Aided Technologies: Platforms for Next Generation Biological Applications aims to provide comprehensive information of microfluidic technologies, their development and biomedical applications. The book opens with an overview of the fundamentals of microfluidics. It is followed by discussions of methods and biomedical applications of microfluidics in diagnostics, prognostics, cell engineering, gene sequencing, cellular analysis, and bioimaging. The book also explores breakthroughs in microfluidics such as 3D bioprinting, organ-on-chip technologies, and regenerative medicine. This book offers researchers an interdisciplinary perspective towards biological problems. It is a resource for advanced undergraduate, graduate students, researchers and industry scientists interested in the emergence of advance techniques and next generation microfluidics-aided technologies for applications in the biomedical and medical research.

Biosensors for Foodborne Pathogens Detection: A Rapid Detection Approach covers rapid and accurate measurement for biosensing analysis. This book is organized in a systematic way, covering basic introduction and advanced approaches in biosensing and their use in the detection of food pathogens. This compilation includes chapters such as Methods, techniques and latest developments in the detection of foodborne pathogens; Basic principles in Biosensors and bioelectronics for the foodborne pathogens; Various bio-recognition receptors used in the biosensors; Nanomaterials and signal amplification in biosensors for foodborne pathogens; electrochemical biosensors for foodborne pathogens; Optical biosensors for foodborne pathogens, and more. This book act as a comprehensive resource for researchers or scientists working in food safety, especially in microbial food spoilage detection using biosensors.

Antibiotics: Therapeutic Spectrum and Limitations provides up-to-date information on managing microbial infections, the development and types of antibiotics, the rationale for utilizing antibiotics, toxicity considerations, and the control of antibiotic resistance in one single resource. This book also aims to provide comprehensive insights and current trends on antibiotic therapies to treat microbial infections, their mechanisms of action, and the role of modern drug delivery in improving their efficacy. Written by leading experts from around the globe, the chapters in the book covers important aspects of microbial infections including hospital acquired infections and community acquired infections and adult sepsis, examines the various types of antibiotics with different mechanisms and therapeutic uses, the global challenge of antibiotic resistance, and clinical trials, regulatory considerations, and market overview of antibiotics. Furthermore, the chapters include updated literature reviews of the relevant key topics, high-quality illustrations, chemical structures, flowcharts, and well-organized tables, all of which enable better understanding by the readers.

Higher Alcohols Production Platforms: From Strain Development to Process Design comprehensively covers the production of higher alcohols, from the fundamentals to the latest research. Bringing together experts from industry and academia, the book sheds light on the practical aspects of higher alcohol production and offers a roadmap for researchers to follow. In addition to the fundamentals of higher alcohol production, readers are presented with detailed information on up and downstream processes, including microbial processes and the various production pathways available. A discussion of metabolic pathways has a dedicated chapter, as do C2, C3-C8, and C4 sugar fermentation platforms. A lifecycle assessment is also presented, addressing the energy, environmental, social and economic factors in the sustainability of higher alcohol production. Readers will find this to be a unique and comprehensive reference on the production of higher alcohols that will be of interest to students, researchers and industry professionals involved in bioenergy and renewable energy, and more.

The Foraging Behavior of the Honeybee (Apis mellifera, L.) provides a scholarly resource for knowledge on the regulation, communication, resource allocation, learning and characteristics of honeybee foraging behavior at the individual and colony level. Foraging, in this context, is the exploration of the environment around a honey bee hive and the collection of resources (pollen, nectar, water, etc.) by bees in the worker caste of a colony. Honeybees have the unique ability to balance conflicting and changing resource needs in rapidly changing environments, thus their characterization as "superorganisms? made up of individuals who act in the interest of the whole. This book explores the fascinating world of honey bees in their struggle to obtain food and resources in the ecosystem and environment around the hive. Written by a team of international experts on honey bee behavior and ecology, this book covers current and historical knowledge, research methods and modeling used in the field of study and includes estimates of key parameters of energy utilization, quantities of materials collected, and identifies inconsistencies or gaps in current knowledge in the field.

PM: Priya KumaraguruparanContact: p.kumaraguruparan@elsevier.com

Features top scholars who provide context and order to new research about mechanisms that underlie both public finance theories and applications. This title focuses on new approaches to both revenue generation and expenditures in public finance. It presents summaries of subjects in public economics that stretch from methodologies to applications.

Statistical learning and analysis techniques have become important today, given the growth in the size of heterogeneous data collections and ability to process it even from physically distant locations. This title familiarize beginners and experts with some of the techniques in this field. It is divided in two sections: Theory and Applications.

Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Helicase Enzymes

Adoptive Cell Transfer, Volume 371 in the International Review of Cell and Molecular Biology series highlights advances in the field, with this new volume presenting interesting chapters written by an international board of authors who expound on topics such as the Impact of tumor microenvironment on Adoptive Cell Transfer activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T cells for solid tumors: rage against the suppressive tumor microenvironment, Improving Adoptive T-Cell therapy with cytokines administration, and What will (and should) be improved in Immunotherapy with CAR? Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Vitamins and Hormones serials Updated release includes the latest information on Parathyroid Hormone

Advances in Virus Research serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Virus Research serials

Advances in Applied Microbiology, Volume 119 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology. Contains contributions from leading authorities in the field Informs and updates on the latest developments in the field of microbiology Includes discussions on the role of specific molecules in pathogen life stages, interactions, and much more

Advances in Agronomy, Volume 175, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors. Includes numerous, timely, state-of-the-art reviews on the latest advancements in agronomy Features distinguished, well recognized authors from around the world Builds upon this venerable and iconic review series Covers the extensive variety and breadth of subject matter in the crop and soil sciences

Advances in Immunology, Volume 154, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering Regulatory T Cells in Infection and Factor H and Properdin and their regulation. Presents current developments and comprehensive reviews in immunology Provides the latest in a longstanding and respected serial on the subject matter

Brillouin Scattering, Part Two, Volume 110 in the Semiconductors and Semimetal series, marks the centenary of Leon Brillouin''s seminal 1922 paper which provided a detailed theory on the effect that now bears his name. Sections in this new release include Optical Fiber Sensors Based on Stimulated Brillouin scattering, Brillouin-based RF frequency sources, SBS for Microwave Photonics (MWP), Engineerable Brillouin processes for integrated photonics, SBS in optical communication systems - the good, the bad and the ugly, Slow light, dynamic gratings and light storage, Non-reciprocity in Brillouin scattering, Electromechanical Brillouin Scattering, and Brillouin light scattering for studying mechanics of biological systems. Stimulated Brillouin Scattering (SBS) is the strongest third order nonlinearity and plays an important role in contemporary science and applications, particularly lasers, communications, fiber optics and basic physics. This volume provides different perspectives on current technological contexts of SBS in a range of different application areas, including sensing, communications, radar, imaging and information storage. Presented by the leading researchers in the field Covers both scientific and technological perspectives Provides different perspectives on current technological contexts of SBS in a range of different application areas, including sensing, communications, radar, imaging and information storage

Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 61 presents the latest release in this continuous series that covers all aspects of rare earth science, including chemistry, life sciences, materials science and physics. Presents up-to-date overviews and new developments in the field of rare earths, covering both their physics and chemistry Contains individual chapters that are comprehensive and broad, along with critical reviews Provides contributions from highly experienced, invited experts

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

International Review on Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology serials Updated release includes the latest information on Sex and Gender Differences in Neurological Disease