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Modern Methods of Drug Design and Development, a volume in the Methods in Enzymology series highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Recombinant protein purification for structural and kinetic studies, Steady-state kinetic analysis of reversible enzyme inhibitors, Steady-State Enzyme Kinetics, Analysis of enzyme kinetic data using ICEKAT, NMR techniques in drug discovery, Dynamic simulations and pre-steady state kinetics to guide drug discovery, Design and assay of substrate-product analogues for racemases and epimerases, Sensitive high throughput methods to screen for P450 inhibition: A- MI complex forming drugs, and more. Other chapters cover Sensitive high throughput methods to screen for P450 inhibition: B-Heme loss causing drugs, Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis, Crystallographic fragment screening in academic cancer drug discovery, Fast fragment- and compound-screening pipeline at the Swiss Light Source, Chemical biology, enzymology and drug discovery, PROTACs, Proximity-Induced Pharmacology (PROTACs), and much more.

Enzymes in RNA Science and Biotechnology, Volume 691 in the Methods in Enzymology series, highlights new advances in the field, including chapters on Reverse transcriptase Part I (discovery, preparation, general utilization, MarathonRT for routine RT-PCR and for cDNA synthesis on challenging RNA templates Structured RNAs, repeat RNAs and more, Engineering TNA Polymerases Through Iterative Cycles of Directed Evolution, Reverse transcriptase Part II (RNA structure mapping and determination), RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays, tRNA Structure-seq in vivo and in droplets, Capture the in vivo intact RNA structurome by CAP-STRUCTURE-seq, and more.

Cannabis and its Derivatives: Guide to Medical Application and Regulatory Challenges summarizes the current state of research and clinical pharmacology of cannabis-based therapeutics, along with associated regulatory frameworks. Sections cover historical, botanical, and taxonomical platforms of cannabis, chemical derivatives of the cannabis plant, a literature review of therapeutic applications, the biological fate of cannabis and its metabolic products, pain management, neurological disorders, cancer management, interactions with other drugs, veterinary applications, and the adverse effects of Cannabis overuse in humans.The book's final section is devoted to discussions around regulatory challenges and future considerations. This is the ideal reference pharmaceutical scientists, clinicians, and academic researchers who want access to updated information on the therapeutic applications of cannabis and its derivates. Corporate researchers will also benefit from this book's presentation of the associated regulatory environment.

Frosting and Icing for Efficient Energy Use in Engineering Applications provides a compendium of innovative case studies for mitigating impacts from frosting and icing on energy. This book first clarifies the mechanisms of frosting and icing, outlining modeling options, and control techniques. Next, a series of experimental examples show the effects of frosting at different scales of energy production, from ambient air vaporizers to wind turbines, and demonstrate how to control these for maximum efficiency. Finally, the mechanisms and mitigation of frosting are examined in a variety of infrastructure scenarios, including sustainable food storage and efficient high-speed railways.Combining the theoretical fundamentals of frosting and icing with a huge range of real-world case studies, this resource shows how to limit energy loss to these effects in key areas of engineering.

Vat Photopolymerization Additive Manufacturing: 3D Printing Processes, Materials, and Applications focuses on the cutting-edge vat polymerization additive manufacturing technology, as well as its associated materials and potential applications. The book is divided into four parts, with the first providing some foundational concepts about the technology as well as providing background on the different vat photopolymerization techniques, such as grayscale, volumetric, multiwavelength, two-photon, and more. The basic chemistry involved in the vat photopolymerization process is covered here as well, as is vat photopolymerization 3D printing of functional materials, including plastics, hydrogels, stimuli-responsive polymers, ceramics, various applications of the materials created, and future directions.

Supercapacitors: Materials, Design, and Commercialization provides a comprehensive overview of the latest research trends and opportunities in supercapacitors, particularly in terms of novel materials and electrolytes. The book addresses the transformation in supercapacitive technology from double layer capacitance to battery-type capacitance, providing a clear understanding of the conceptual differences between various charge storage processes for supercapacitors, charge storage based on materials and electrolytes, and calculation for capacitance for these charge processes. Detailed chapters discuss recent developments in materials, such as carbons, chalcogenides, MXene and phosphorene, various polymer nanocomposites, and polyoxometalates for supercapacitors.This is followed by in-depth coverage of electrolytes, including the evolution of electrolytes from aqueous to water-in-salt electrolytes and their role in improving the energy density of supercapacitors. The final part of the book examines the role of artificial intelligence in the design of supercapacitors, and latest developments in translating novel supercapacitor technologies from laboratory-scale research to a commercialization.

Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology. These changes occur thanks to breakthrough experiments in basic research, and with the help of new technologies that allow for the testing of immunology hypotheses. In recent years, a substantial number of findings have been made around immunometabolism. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

Mathematical Modeling in Bioscience: Theory and Applications provides readers with tools and techniques for mathematical modeling in bioscience through a wide range of novel and intriguing topics. The book concentrates on larger elements of mathematical modeling in bioscience, including topics such as modeling of the Topp--Leone new power generalized Weibull-G distribution family, vector-borne disease modeling, transmission modeling of SARS-COV-2 among other infectious diseases, pattern formulation models, compartmental models for HIV/AIDS transmission, population models, irrigation scheduling models, and predator--prey models. The readers will discover a variety of new methods, approaches, and techniques, as well as a wide range of applications demonstrating key concepts in bioscience modeling. This book provides a leading-edge resource for researchers in a variety of scientific fields who are interested in mathematical modeling, including mathematics, statistics, biology, biomedical engineering, computer science, and applied sciences.

A Roadmap for the Comprehensive Assessment of Natech Risk: Management and Control of Technological Accidents Triggered by Natural Hazards in the Framework of Climate Change covers the latest advancements concerning the quantitative risk assessment and the management of cascading events involving technological accidents caused by natural hazards. The topic is meticulously covered, providing a description of past accidents, case-studies, and quantitative figures that allow for the identification of the most vulnerable plant elements, of the complex features of accident scenarios, and of their rising trend that is possibly related to factors as climate change and growing industrialization.Methodologies aiming at the assessment of the actual performance of safety barriers and safety systems during or immediately after the impact of a natural event are also presented. Recent tools and data supporting the quantitative assessment of these features in the overall assessment of Natech risk are reported, highlighting the similarities with other typologies of cascading accidents. Several case studies are presented in the book, and each methodology presented is provided with an illustrative case-study providing guidance to its application.

Fundamentals of Membrane Separation Technology provides a comprehensive and systematic introduction to this environmentally-friendly separation process. Using a structured format that promotes comprehension and implementation, each chapter provides overviews, principles, materials, preparation, and industrial applications. Each chapter then concludes with future prospects, references, and end-of-chapter exercises. Written for students and professionals, this book is an ideal reference for those who wish to better understand the fundamentals and applications of membrane technology.

Wetlands for Water Pollution Control, Third Edition, formerly known as Wetland Systems to Control Urban Runoff, covers broad water and environmental engineering aspects relevant for the drainage and treatment of stormwater and wastewater, providing a descriptive overview of complex 'black box' treatment systems and general design issues involved. Fundamental science and engineering principles are explained to address the student and professional market. Standard and novel design recommendations for predominantly constructed wetlands and related sustainable drainage systems are also provided to account for interests of professional engineers and environmental scientists. Users will find the latest research in wastewater treatment and runoff control presented in a manner that is ideal for academics, senior consultants, final year and postgraduate students, and graduate engineers, respectively.

Fragile X and Related Autism Spectrum Disorders, Volume 172 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on The dopamine hypothesis of Autism Spectrum Disorder: a comprehensive analysis of the evidence, A Review of the Use of Psychotropic Medication to Address Challenging Behavior in Neurodevelopmental Disorders, Lipid metabolism alterations in fragile X syndrome and other neurodevelopmental disorders, Genesis, modelling and methodological remedies to autism heterogeneity, Toward an Understanding of the Role of the Exposome on Fragile X Phenotypes, Glial-mediated dysregulation of neurodevelopment in Fragile X Syndrome, and more.

Solid State Physics, Volume 74, the latest release in this serial that highlights new advances in the field, presents interesting chapters written by an international board of authors.

Natural Products, Volume 61 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on Chemical evolution of natural product structure for drug discovery, Fungal Metabolites, Polypharmacology of Natural Products, Glycopeptide Antibiotics, and Natural products-based drug discovery for the CNS.

P450 Enzymes, Volume 692 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release cover Non-natural P450 reaction (carbene/nitrene), Non-natural P450 reaction (atom transfer radical cyclization), P450 fusion for biocatalysis, P450 fingerprinting for biocatalytic oxidation, Fungal peroxygenase, Fungal peroxygenase, Anti-Markovnikov P450 oxygenase (AmOX), Fungal P450, Unusual P450 chemistry from fungal sources, CASTing for P450 biocatalysis, and P450 in C-C coupling of cyclic dipeptides with nucleobases.

The Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicling biochemical processes and pathways, Metabolism and Catalysis, Mitochondrial ATP synthase, The respiratory chain, A century of mitochondrial research, Five decades of metalloenzymology, Mechanisms of catalysis, Mitochondrial fatty acid synthesis and associated processes, Signaling, MAPK cascades: Origins, mechanisms and current status, Sphingolipids: From structural components to signaling hubs, Protein Homeostasis and Hydrolysis, Mitochondrial AAA+ proteases, Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity. Other sections cover DNA Replication and Repair, Structure-function studies of DNA replication proteins, and Helicases required for nucleotide excision repair.

Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic offers an advanced exploration into the comprehensive understanding of disease etiology and prognosis through multiomics approaches. This authoritative volume delves into the applications of multiomics technology in elucidating complex human health conditions and diseases. It introduces the technology's potential for biomarker identification, drug discovery, and disease prognostication. For a thorough understanding of human health and diseases, particularly cancer, it is essential to integrate knowledge of molecular biomarkers across multiple omics levels, including the genome, epigenome, transcriptome, proteome, and metabolome. This resource addresses the current gaps in knowledge among students and researchers, providing in-depth coverage of multiomics technology and its implementation in scientific research and discovery.Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omics is a pioneering resource that presents cutting-edge information on contemporary multiomics technologies for big data interpretation and their applications in deciphering complex human pathobiology. This comprehensive guide is indispensable for researchers, academics, students, and industry professionals alike.

Reverse Vaccinology: Concept, Methods, and Advancement presents the development strategy of new vaccines through genome sequencing bioinformatics analysis. This book promises to revolutionize vaccine development, especially for pathogens to which the classical applications of Pasteur’s principles have failed, and it is explained in detail in this book.This book is split into three sections: the first, Concept, brings the basis of reverse vaccinology, vaccine antigen discovery, and subunit vaccine; the second, Tools and Methods, describes immunoinformatic, proteomics for epitope-vaccine design, databases, network analysis, machine learning, and NGS-driven antigen screening technology; and the last one, Disease Case Study, discusses real-world examples in the development of new vaccines for diverse diseases.It is a valuable resource for bioinformaticians, researchers, students, and members of the biomedical and medical fields who want to learn more about a new and agile process for the development of new vaccines.

Neurotoxicity of Halogenated Organic Compounds, Volume 10 covers three groups of Halogenated Organic Compounds (Chlorinated, Brominated, and Fluorinated Compounds) that are legacy and emerging contaminants, providing background information, characteristics, physicochemical properties, environmental contamination, and human exposure. Specific chapters covered in this release include Perspective on Halogenated Organic Compounds, The Neurotoxicity of Polychlorinated Biphenyls (PCBs), Neuroendocrine Effects of Polychlorinated Biphenyls (PCBs), Mechanisms of PCB Neurotoxicity: AHR and THR Dogma meet RYR reality, Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs), and much more. Other chapters cover Neuroendocrine Effects of Brominated Flame Retardants (BFRs), Focused on Polybrominated Diphenyl Ethers (PBDEs), Neurochemical Effects of Halogenated Organic Compounds: Possible Mode(s) of action and Structure-Activity Relationships, The Neurotoxic Effects of Perfluoroalkyl Substances (PFAS) in Animal Models and Human Cohorts, Neurochemical Mechanisms of Perfluoroalkyl Substances (PFAS) Neurotoxic Action, and Future Directions and Regulatory aspects of Halogenated Organic Compounds.

International Review of Cell and Molecular Biology, Volume 381 highlights new advances in the field, with this new volume presenting interesting topic on Overview of Inflammatory Breast Cancer: Updates.

Social and Communicative Functioning in Populations with Intellectual Disability: A Developmental Perspective, Volume 65 in the International Review of Research in Developmental Disabilities series, focuses on social and communicative functioning with a particular emphasis on people with intellectual disability. The volume brings together international researchers across disciplines to highlight innovative approaches to holistically describe social and communicative abilities in this population including teleassessment, self-report, and community-engaged research designs. Through a lifespan approach, key issues are raised related to social and communicative functioning across a range of communication modalities from infancy through adulthood. Additional chapters cover Adaptation of in-person tools for remote assessment of infants and toddlers with social communication concerns in community-based settings, Measuring social communication in people with ID who use minimal speech: Differences across the lifespan, and Social Inclusion of Adults with IDD: Toward Belonging, Building a Life: Examining the advocacy and social experiences of students with IDD in inclusive postsecondary education.

Stratigraphy and Timescales, Volume Eight in the Advances in Sequence Stratigraphy series, covers research in stratigraphic disciplines, including recent developments in the geosciences. This fully commissioned publication aims to foster and convey progress in stratigraphy with its inclusion of a variety of topics, including The fusulinids of a carbonate platform in Middle Permian Maokou Formation (Guadalupian) in eastern Sichuan Basin, China, Provenance of the Neogene sedimentary rocks of Sabah: the Kudat Formation, circular basins and the Crocker Unconformity revisited, The Neogene West Baram Delta, Ages and provenance of sedimentary rocks from Northwest Sulawesi and East Kalimantan: the Neogene Mahakam Delta, and much more.

Dystonia, Volume 169, the latest release in the International Review of Neurobiology serial, highlights new advances in the field with this new volume presenting interesting chapters on topics including Clinical Features and the Science of Classification, What Can Epidemiological Studies Tell us About the Neurobiology of Dystonia, Dystonia Genes and Their Biological Pathways, Functional Anatomy of Dystonia, Physiology of Dystonia: Human Studies, Physiology of Dystonia: Animal Studies, Experimental Pharmacology: Targeting Neurotransmitters, Experimental Pharmacology: Targeting Metabolic Pathways, Adult-Onset Focal Dystonias: One Biology or Many?, Early-Onset Inherited vs Late-Onset Idiopathic Dystonias: Same or Different Biological Mechanisms?, and much more.

Biofilms, Volume 53 in the ongoing Methods in Microbiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, including Monospecies and polymicrobial biofilms in static and flow environment, Methods used to study biofilms, Spatial analysis of bacterial biofilms, Biofilm grown in bioreactors, Single-cell analysis of subpopulations within biofilms using microscopy, flow cytometry, and imaging flow cytometry, Microscopy analysis of biofilm-mineral interactions or mineral formation within biofilms, Bacterial biofilms as an essential component of rhizosphere plant-microbe interactions, Studying Gene Expression in Biofilms, and more.

ZIP Metal Ion Transporters, Volume 684 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Biochemistry, Biophysics and Structural Biology, Structure determination of a bacterial ZIP in lipidic cubic phase, Cell-based metal transport assay for animal and plant ZIPs, Measurement of metal binding affinity and transport activity in ZIP transporters using spectroscopic methods, Considerations in production of the (prokaryotic) ZIP family transporters for structural and functional studies, Metal-protein interactions investigated using model systems: thermodynamic, spectroscopic and computational methods, and more. Additional chapters cover Getting Zinc Into and Out of Cells, In-silico modeling of ZIP9 (TBD), Cellular Function and Regulation, Methods to visualize zinc transporter proteins of the SLC39A family in cells, Assessing metal ion transporting activity of ZIPs: intracellular zinc and iron detection, In vitro studies for studying manganese transport and homeostasis, and much more.

Phage Therapy - Part B, Volume 201 covers bacteriophage and their isolation, screening, synthetic phage, diagnostics, directed evolution, host interaction, and more. The book's aim is to highlight a number of aspects of phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform research. Sections cover Phages for the treatment of Pseudomonas aeruginosa infection, Phage for the treatment of Vibrio cholerae infection, Phages for the treatment of Mycobacterium species, Phage therapy for gut microbiome, Phages as delivery vehicles, Phage display, Unlocking the potential of Phages: Innovative Approaches to harnessing Bacteriophages as Diagnostic Tools for Human Diseases, and more. Other sections explore Phage display and human disease detection, Bacteriophage as Cargo and its application in nanomedicine, Phage for drug delivery vehicles, Genome editing for phage design and uses for therapeutic applications, Phage for cancer therapy, and Phage for regenerative medicine and cosmetics.

Photoelectrochemical Engineering for Solar Harvesting: Chemistry, Materials, Devices provides an up-to-date appraisal of the photon engineering of innovative catalysts for solar energy harvesting. This book analyzes the overall progress, potential challenges, and the industrialization of new catalysts in the near future. The primary emphasis is on experimental approaches from materials synthesis to device applications, however, there is also an introduction to relevant photochemistry concepts. This book is suitable for materials scientists and chemists who, through the use of photonics, are in continuous pursuit of improving the efficiencies of different devices used to capture solar energy for the generation of sustainable fuel. Sunlight-driven fuel synthesis is the most sustainable and potentially economical option for producing energy vectors through water splitting. Thus, this book focuses on the design of photocatalysts and water oxidation catalysts, as artificial photosynthesis and hydrogen fuel production via water oxidation (in place of fossil fuels) are two promising approaches towards renewable energy.

Recapitulating The Stem Cell Niche Ex Vivo, Volume Six in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Recapitulating the bone marrow stem cell niche ex vivo, The generation of the liver ex vivo, Recapitulating the thymic stem cell niche ex vivo, Recapitulating the intestinal epithelium stem cell niche ex vivo, Recapitulating the lung stem cell niche in vitro, Recapitulating mammary tissue in vitro, and Recapitulating muscle in vitro.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.