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give warnings, disclaimers, and the like.* The main objective of Protein and Peptide Analysis by Mass Spec trometry is quite straightforward-to present authoritative, up-to-date, and practical accounts of the use of mass spectrometry in the analysis of pep tides and proteins.

The development of recombinant DNA technology and methods for transferring recombinant genes into plants has brought about significant advances in plant science.

Here, as with enzymatic DNA sequencing, is a very simple concept that relies on minimal information to prepare short oligonucleotide primers that direct the synthesis of a specified fi-agment o f DNA in the presence of a thermostable DNA polymerase.

Harry Baker and Rosalind Ridley have done an admirable job in assem bling this collection of articles that describe the methodology frequently used to study a group of CNS illnesses often referred to as the "prion diseases."

In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy.

The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research.

Psychiatric Genetics provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions.

Minimally invasive urologic surgery is revolutionizing how physicians treat many urologic diseases. Laparoscopic Urologic Oncology focuses on educating both general urologists and urologic oncologists on the current and future role of laparoscopy and other minimally invasive techniques in urologic oncology.

In Buprenorphine Therapy of Opiate Addiction, participating physicians and toxicologists summarize and evaluate their experiences with five years of intensive buprenorphine therapy.

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities.

Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level.

A treasure trove of uncommon and reliable scientific and clinical information for the toxicity and usefulness of today's leading nonherbal dietary supplements. Also presented are case reports of adverse effects and interactions, as well as information on reproductive effects, chemical and biofluid analysis, and regulatory status.

Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism.

In keeping with the organization used effectively in other volumes in this series, each chapter has a brief introduction followed by a list of required items, protocols, and notes designed to help the reader perform the expe- ments without difficulty.

Recent research has greatly expanded our understanding of the sophisticated molecular network of responses in plants. Here, an international panel of experts provides well-established methods vital to analyzing plant signal transduction on the molecular level.

The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease.

This book offers a useful bench reference, organized based on systemic pathology, and includnig references and information on recently developed drug classes including biologics. Includes more than 700 illustrations collected by the authors over many years.

A collection of new reviews and protocols from leading experts in cell cycle regulation, Cell Cycle Control: Mechanisms and Protocols, Second Edition presents a comprehensive guide to recent technical and theoretical advancements in the field.

Clinical research in critical care has exploded in the past several years and we now have a much better understanding of how to care for intensive care unit (ICU) patients in areas such as management of sepsis, fluid resuscitation, mechanical ventilation, antibiotic administration and sedation and analgesia.

Bladder Dysfunction in the Adult

In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance.

Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling.

The origin of modern intensive care units (ICUs) has frequently been attributed to the widespread provision of mechanical ventilation within dedicated hospital areas during the 1952 Copenhagen polio epidemic.

Imaging Coronary Atherosclerosis

Engineering Multicellular Systems: Methods and Protocols, focuses on laboratory procedures used in recent efforts for constructing synthetic multicellular systems and their applications.

Integrative Weight Management

Integrative Therapies in Lung Health and Sleep provides an overview of integrative therapies to assist clinicians caring for patients with acute or chronic lung diseases and sleep disorders--emphasizing the scientific bases for these therapies;

Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.