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The prmcipal objective of Bioremediation Protocols is to make the fruits of some of this research available in a different format to that of the textbook or journal article. In common with p- wous volumes in this and the companion Methods in Molecular Biology series, an extensive "Notes" section is provided with each chapter.

This Methods in Molecular Biology book offers in vitro and in vivo protocols on mutation assays, cytogenetic techniques, primary DNA damage, alternate assays to animal models and updated ICH guidelines. Includes material lists, troubleshooting tips and more.

Investigations involving incisive mechanistic dissection of various types of synaptic plasticity have revealed that it plays key roles in neural development, sensory information processing, cortical remapping following brain injury, perception, and behavioral learning and memory.

Unique among bacteria, they include species possessing cells with intracellular membrane-bounded compartments and a peptidoglycan-less cell wall, and bacteria such as the anammox organisms performing unique anaerobic ammonium oxidation significant for global nitrogen cycle.

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery.

Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine.

The purpose of Renal Cancer: Methods and Protocols is to introduce the surgeon, clinician, investigator, and research scientist to the basic methods employed in the diagnosis and treatment of renal cancer.

Herpes Simplex Virus Protocols comprises a wide range of experimental protocols that should be especially useful to new workers in herpes virology. Obviously the range of topics covered cannot be comprehensive, but we have tried to provide protocols dealing with those procedures that are most widely used;

Physician-Assisted Death is the eleventh volume of Biomedical Ethics Reviews.

They not only review such problems as obstructive sleep apnea, insomnia, circadian rhythm disorders, and narcolepsy, but they also discuss such important topics as pediatric sleep disorders, the pharmacology of sleep medicines, diagnostic testing and technology, and the use of bright light therapy in sleep disorders and depression.

A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies.

This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells.

Diet quality is a broad term that encapsulates both perceived and actual practices, personal preferences and cultural diversity. In this book, Diet Quality: An Evidence-Based Approach, Volume 1 all of the major facets of diet quality in relation to health outcomes are covered.

Diet quality is a broad term that encapsulates both perceived and actual practices, personal preferences and cultural diversity. In this book, Diet Quality: An Evidence-Based Approach, Volume 2 all of the major facets of diet quality in relation to health outcomes are covered.

There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

This book presents a broad yet focused treatment of central topics in the field of clinical neurophysiology. The volume was inspired by the clinical neurophysiology lecture series at Beth Israel-Deaconess Medical Center and Rhode Island Hospital.

This book is an up-to-date and comprehensive reference on lipidology. It will serve as a stimulus to the reader to continue to learn about the ever changing and fascinating field of therapeutic lipidology. It will also empower readers to improve and extend the lives of the patients they so conscientiously serve.

In the diagnosis and treatment of movement disorders, the use of neuroimaging has expanded widely and has been an exciting, important modality for unlocking the causes of abnormal motor control.

While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management.

This is a comprehensive and novel text that examines key features that predispose individuals to autoimmune diseases. The first section details the basic mechanism of autoimmunity and examines immunogenetic and environmental factors in autoimmunity. The next section examines autoimmune thyroid disease.

This text is a review of current management techniques for pituitary tumors, incorporating recent advances and discussions by experienced clinicians. The use of both endocrinologists and neurosurgeons as chapter authors allows differing perspectives to be incorporated.

This book addresses diabetes controversies, specifically in the management of etiology and the disease itself. The volume covers commonly accepted forms of therapies and complications, as well as new and emerging advances and therapies and inadequacies in several standard treatments.

This informative Neuromethods series book surveys the cytoskeleton, and offers detailed protocols on emerging techniques including in vivo and in vitro imaging and preparative strategies for isolation of cytoskeletal components of the central nervous system.

The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.

Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases.

However, upon further reflection we accepted a place for a book that could combine our career this mandate as a blessing in disguise, allowing the experiences of trying to discern what is known (and reader to focus on differences in morphology, rather knowable) with the perennially proposed question, than tincture, as a guide to correct diagnosis.

A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL.

Leading physicians from a variety of medical specialties summarize their clinical experiences in treating pituitary adenomas in United States and the United Kingdom. Using simple language to describe their approaches, the authors describe the latest treatments for prolactinoma, acromegaly, Cushing's disease, and nonfunctioning pituitary tumors, and the latest surgical techniques. To round out the clinician's understanding of the illness, a patient describes the experience of diagnosis, treatment, and follow-up. Comprehensive and accessible, Management of Pituitary Tumors: The Clinician's Practical Guide brings together all the medical fields involved in treating pituitary tumors, both for novices in the specialties that manage these cases, and for pituitary specialists seeking to understand better the contribution of other medical disciplines to the treatment of these tumors.

Dopamine, a catecholamine transmitter, plays a number of vital physiological roles in the brain and body, and, in recent years, studies on the role of dopamine in disease have opened new avenues of research and discovery.

This Neuromethods series book reviews methods for generating lesions and for stimulating and inhibiting neural pathways, covering new techniques such as optogenetics and the use of the in situ perfused preparation and reassessing well-known approaches.