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Highlights in Skincancer is a companion handbook published expressly for all the practitionners who are interested in skin cancers: medical oncologists and dermatologists but also residents, general practitionners, surgeons, plastic surgeons. The book is designed to teach new aspects of skincancers in the context of practical clinical settings.Each topic is an expert view of a specific skincancer field. Highlights in Skincancer provides information on a wide range of skincancer topics with emphasis on the emergence of new diagnostic approaches, therapeutic perspectives, and a better insight into the biology of the skin tumours. No doubt that the Highlights in Skincancer will be considered as a real tool throughout a medical career.

An increase in aortic aneurysm occurrence is registered, despite considerable advances in surgical interventions. Consequently, numerous researchers have been trying to improve the understanding the aortic aneurysm pathogenesis in order to facilitate an early diagnosis, to identify new therapeutic targets, and to develop complex therapies. Within this book, the reader may find interesting data about etiology, risk factors, and pathogenesis of aortic aneurysm, its characteristics in young age, particularities of aneurysms affecting visceral arteries, the preoperative evaluation of the patients, different perspectives regarding the surgical therapy, including the treatment of complications after prior surgery, original proposals regarding new therapeutic modalities, and advanced imaging strategies. The multidisciplinary team of authors provides an interesting lecture and an update of the scientific literature.

Neil S. Lagali, PhD, obtained undergraduate (McMaster University) and graduate (University of Alberta) degrees in Canada. He has had several years of industry experience and held postdoctoral fellowships in Canada, The Netherlands, and Sweden. He has published over 35 peer-reviewed articles in international journals in the fields of engineering, biomedical optics, biomaterials, ophthalmology, and translational medicine. He has co-authored several book chapters, and holds patents in the fields of optical devices, biosensors, and non-invasive imaging methods. He gives numerous lectures and courses on microscopy and clinical imaging, is a regular invited speaker and session organizer at international conferences, and is an associate editor for the journal BMC Ophthalmology. Dr. Lagali is with the Department of Clinical and Experimental Medicine, Linkoping University, Sweden.

Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans. On the other side, many problems arise when stem cells encounter the mature brain parenchyma, still hampering the development of efficacious therapeutic approaches with endogenous or exogenously-delivered neural stem cells. This book tries to make the point on these extremely promising, yet unresolved, issues.

Studies of herbivory provide important insights into fundamental questions in many areas of the biological sciences. The focus on natural systems is more effective for the prediction of potential changes in ecosystems, given that agricultural systems are designed to create an equilibrium that optimizes the productive process. Given the ramifications of the processes related to herbivory, studies based on complementary approaches are necessary for a better understanding of the different aspects of the ecological process. This book attempts to expand on these different aspects of herbivory by presenting a multidisciplinary approach to a number of different themes, focusing on topics that range from basic research in natural habitats to the intrinsic relationships between animals and plants in agricultural systems.

This book collects the contributions of a number of clinical psychiatrists all over the world, interested in developing basic research about anxiety and in applying it in clinical contexts. It is divided into four sections, covering general issues about anxiety (ethological and developmental ones), basic research issues on specific aspects of anxiety (bioanatomical ones, correlation with personality structure and so on), and new clinical and therapeutical proposals and hypothesis. Each author summarized the clinical importance of his work, underlining the clinical pitfalls of this publication.

Down syndrome, the most cutting-edge book in the field congenital disorders. This book features up-to-date, well referenced research and review articles on Down syndrome. Research workers, scientists, medical graduates and pediatricians will find it to be an excellent source for references and review. It is hoped that such individuals will view this book as a resource that can be consulted during all stages of their research and clinical investigations.Key features of this book are:Common diseases in Down syndromeMolecular Genetics Neurological DisordersPrenatal Diagnosis and Genetic Counselling Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents, relatives and health-care providers who work with infants and children with Down syndrome.

Atrial fibrillation is a rapidly evolving epidemic associated with increased cardiovascular morbidity and mortality, and its prevalence has increased over the past few decades. In the past few years, the recent understanding of the diverse mechanisms of this arrhythmia has lead to the improvement of our therapeutic strategies. However, many clinicians have still felt the frustration in management of this commonly encountered arrhythmia. This book contains a spectrum of different topics from bench to bedside in atrial fibrillation. We strongly believe that scientists, cardiologists and electrophysiologists will find this book very informative and useful and the references cited in each chapter will definitely act as an additional source of information for readers.

This unique resource presents current issues in sports and exercise medicine which outlines new areas of knowledge and provides updates on current knowledge in the broad field of sports and exercise medicine.Written by experts in their own sub-disciplines, Current Issues in Sports and Exercise Medicine discusses the physiology behind sports injuries and presents new and exciting approaches to manage such injuries. In addition, the book explores the relationship between exercise, health and performance by providing new information in areas such as exercise and immunity, the use of iron supplementation for performance, how exercise affects reactive oxygen species, and the proposed benefits of real and simulated altitude training.This book is well referenced and illustrated and will be a valuable resource for sports medicine specialists, physiologists, coaches, physical conditioners, physiotherapists and graduate and medical school students.

Crystal growth is the key step of a great number of very important applications. The development of new devices and products, from the traditional microelectronic industry to pharmaceutical industry and many others, depends on crystallization processes.The objective of this book is not to cover all areas of crystal growth but just present, as specified in the title, important selected topics, as applied to organic and inorganic systems. All authors have been selected for being key researchers in their field of specialization, working in important universities and research labs around the world.The first section is mainly devoted to biological systems and covers topics like proteins, bone and ice crystallization. The second section brings some applications to inorganic systems and describes more general growth techniques like chemical vapor crystallization and electrodeposition.This book is mostly recommended for students working in the field of crystal growth and for scientists and engineers in the fields of crystalline materials, crystal engineering and the industrial applications of crystallization processes.

The purpose of this book is to introduce researchers and practitioners to recent advances and applications of Monte Carlo Simulation (MCS). Random sampling is the key of the MCS technique. The 11 chapters of this book collectively illustrates how such a sampling technique is exploited to solve difficult problems or analyze complex systems in various engineering and science domains. Issues related to the use of MCS including goodness-of-fit, uncertainty evaluation, variance reduction, optimization, and statistical estimation are discussed and examples of solutions are given. Novel applications of MCS are demonstrated in financial systems modeling, estimation of transition behavior of organic molecules, chemical reaction, particle diffusion, kinetic simulation of biophysics and biological data, and healthcare practices. To enlarge the accessibility of this book, both field-specific background materials and field-specific usages of MCS are introduced in most chapters. The aim of this book is to unify knowledge of MCS from different fields to facilitate research and new applications of MCS.

"Bioactive Food Peptides in Health and Disease" highlights recent developments on bioactive food peptides for the promotion of human health and the prevention/management of chronic diseases. The book provides a comprehensive revision of bioactive peptides obtained from both animal and plant food sources. Aspects related to their bioactivity, mechanism of action, and bioavailability are extensively described along the different chapters. Also, the chapters describe the impact of bioactive peptides on the physiological absorption, regulation and disease prevention. The book also covers the recent technological advances for the production of food peptides. Bioactive Food Peptides in Health and Disease provides updated and interesting information, being a good reference book for nutritional and food scientists, biochemists, industry producers, and consumers.

The aim of this book is to disseminate state-of-the-art research and advances in the area of nuclear reactors technology. The book was divided in two parts.Topics discussed in the first part of this compilation include: experimental investigation and computational validation of thermal stratification in PWR reactors piping systems, new methods in doppler broadening function calculation for nuclear reactors fuel temperature, isothermal phase transformation of uranium-zirconium-niobium alloys for advanced nuclear fuel, reactivity Monte Carlo burnup simulations of enriched gadolinium burnable poison for PWR fuel, utilization of thermal analysis technique for study of uranium-molybdenum fuel alloy, probabilistic safety assessment applied to research reactors, and a review on the state-of-the art and current trends of next generation reactors. The second part includes: thermal hydraulics study for a ultra high temperature reactor with packed sphere fuels, benefits in using lead-208 coolant for fast reactors and accelerator driven systems, nuclear power as a basis for future electricity production in the world: Generation III and IV reactors, nanostructural materials and shaped solids for improvement and energetic effectiveness of nuclear reactors safety and radioactive wastes, multilateral nuclear approach to nuclear fuel cycles, and a cold analysis of the Fukushima accident.

This book focuses on the current research in the area of rheology. Rheological characterizations are performed on materials in order to understand the basic nature of a system, quality control of raw materials and final products. The rheological characterizations are important to study the effect of different parameters such as formulation, shelf life and temperature on the quality of final products. The book covers a broad range of rheology related topics such as microrheology, capillary rheolgical measurements, characterization of dense suspensions and numerical analysis of viscoelastic fluids.

Artificial neural networks may probably be the single most successful technology in the last two decades which has been widely used in a large variety of applications. The purpose of this book is to provide recent advances of architectures, methodologies, and applications of artificial neural networks. The book consists of two parts: the architecture part covers architectures, design, optimization, and analysis of artificial neural networks; the applications part covers applications of artificial neural networks in a wide range of areas including biomedical, industrial, physics, and financial applications. Thus, this book will be a fundamental source of recent advances and applications of artificial neural networks. The target audience of this book includes college and graduate students, and engineers in companies.

The Earth is the only planet in our solar system that supports life. The complex process of evolution occurred on Earth only because of some unique environmental conditions that were present: water, an oxygen-rich atmosphere, and a suitable surface temperature. Climate change refers to a statistically significant variation in either the mean state of the climate or in its variability, persisting for an extended period (typically decades or longer). Thus, it requires field of attention towards reduction in the rise in atmospheric temperature, by controlling emitted greenhouse gases into the atmosphere in order to preserve natural resources and by introducing new technologies on alternative fuels.This book presents the fundamental effect on the origin of climate change, impacts over ice cap, melting of Arctic ice, rise in sea level and related technologies that can be implemented to cultivate our land for agriculture, growing forestation to reduce the impact of temperature rise and disaster on human being as well as on other livelihood. This also need to strive for novel policies that world leader should adopt.

Biomedical Engineering is an exciting and emerging interdisciplinary field that combines engineering with life sciences. The relevance of this area can be perceived in our everyday lives every time we go to hospital, receive medical treatment or even when we buy health products such as an automatic blood pressure monitor device. Over the past years we have experienced a great technological development in health care and this is due to the joint work of engineers, mathematicians, physicians, computer scientists and many other professionals.This book introduces a collection of papers organized into three sections that provide state of the art examples of practical applications in Biomedical Engineering in the area of Biomedical Signal Processing and Modelling, Biomaterials and Prosthetic Devices, and Biomedical Image Processing.

Gastric cancer is the second most common cause of cancer-related death in the world. There are no screening tests available for its diagnosis, therefore patients usually presents in late stages, associated with poor prognosis. Currently, many efforts are made toward new advances in the treatment strategies. The book makes an insight into the assessment of premalignant lesions, current management of early gastric cancer, risk and protective factors in gastric carcinogenesis. "Gastric cancer" provides a detailed description of the morphologic classification, molecular changes and epigenetic alterations of this tumor. The book describes the role of different diagnostic tools in the preoperative assessment of patients and the most important factors contributing to the prognosis. Moreover, it describes the current surgical and chemotherapeutic options for gastric neoplasm. This publication may open new and interesting gates for further research concerning carcinogenesis, genetic and epigenetic alterations, signaling pathways, H. pylori infection, the discovery of protective factors against gastric cancer and of revolutionary therapies of this tumor.

Recently, some SiC power devices such as Schottky-barrier diodes (SBDs), metal-oxide-semiconductor field-effect-transistors (MOSFETs), junction FETs (JFETs), and their integrated modules have come onto the market. However, to stably supply them and reduce their cost, further improvements for material characterizations and those for device processing are still necessary. This book abundantly describes recent technologies on manufacturing, processing, characterization, modeling, and so on for SiC devices. In particular, for explanation of technologies, I was always careful to argue physics underlying the technologies as much as possible. If this book could be a little helpful to progress of SiC devices, it will be my unexpected happiness.

This book provides an understanding on a large variety of related topics in fish biology. The further development on molecular and cellular biology and ecology leads to assimilate the newer scientific knowledge in this area. Leading research works from around the world are brought together in this book to produce a valuable source of reference for teachers, researcher, and advanced students of biological science. The fist three chapters of this book give a general description of the complex biology of the immune response. Detailed descriptions were also included on understanding of cytokine regulation in teleost immune system. The second three chapters provide information on the environmental stressors on the responses of freshwater fish across molecular to population level. Then, the following two chapters review two special topics; the roles of the atrium and the ventricle across teleost species and the tracer methodologies on the measurements of carbohydrate metabolism. The last chapter discusses the variables that are involved in the feeding behavior of a predatory freshwater fish species.

This book contains a wealth of useful information on current research on viscoelasticity. By covering a broad variety of rheology, non-Newtonian fluid mechanics and viscoelasticity-related topics, this book is addressed to a wide spectrum of academic and applied researchers and scientists but it could also prove useful to industry specialists. The subject areas include, theory, simulations, biological materials and food products among others.

Despite significant accomplishments to date, kidney transplantation is a relatively young field in medicine. Due to the armamentarium of agents available to effectively suppress the immune system, the past decade has seen a shift in focus from prevention of rejection to a focus on extending the life of the allograft and novel strategies to increase the organ donor pool. This book covers basic concepts in kidney transplantation while also addressing ways to manage kidney transplant recipients in order to maximize patient and graft survival. In addition, novel concepts to increase organ availability are addressed, including kidney paired donation and single site laparoendoscopic donor nephrectomy for living donor kidney transplantation, and utilization of marginal, hepatitis C positive, and older donor organs to increase deceased donor transplant opportunities.

Oil and gas are the most important non-renewable sources of energy. Exploring, producing and managing these resources in compliance with HSE standards are challenging tasks. New technologies, workflows and procedures have to be implemented.This book deals with some of these themes and describes some of the advanced technologies related to the oil and gas industry from HSE to field management issues. Some new technologies for geo-modeling, transient well testing and digital rock physics are also introduced. There are many more technical topics to be addressed in future books. This book is aimed at researchers, petroleum engineers, geoscientists and people working within the petroleum industry.

In this book, a wide range of different topics related to analytical as well as numerical solutions of problems related to scattering, propagation, radiation, and emission in different medium are discussed. Design of several devices and their measurements aspects are introduced. Topics related to microwave region as well as Terahertz and quasi-optical region are considered. Bi-isotropic metamaterial in optical region is investigated. Interesting numerical methods in frequency domain and time domain for scattering, radiation, forward as well as reverse problems and microwave imaging are summarized. Therefore, the book will satisfy different tastes for engineers interested for example in microwave engineering, antennas, and numerical methods.

This book reflects a major medical problem which is still under thorough studies. There is a number of clinical cases corresponding directly or indirectly to a certain alteration of the immune system, thus leading to various pathologic conditions. The unique defense, what humans have with their immunity, is rather often affected by infections, tumor processes, organ, tissue and cell transplantation, allergy, autoimmune processes, as well as different influences by the environment. The Book has an international team of authors all contributing to the investigation of the questions of what, why, how, when and where the immune system deviates from its normal function, what clinical consequences are manifested and is there a way to prevent and treat the immunodeficiency cases. This Book can be a very good teaching tool for students and post-docs of medicine and biology, but it also provides updated information for the colleagues immunologists, microbiologists, virologists, chemotherapists, oncologists, hematologists, transplantologists and pathologist.

This book discusses aspects of laser pulses generation, characterization, and practical applications. Some new achievements in theory, experiments, and design are demonstrated. The introductive chapter shortly overviews the physical principles of pulsed lasers operation with pulse durations from seconds to yoctoseconds. A theory of mode-locking, based on the optical noise concept, is discussed. With this approximation, all paradoxes of ultrashort laser pulse formation have been explained. The book includes examples of very delicate laser operation in biomedical areas and extremely high power systems used for material processing and water purification. We hope this book will be useful for engineers and managers, for professors and students, and for those who are interested in laser science and technologies.

The advent of X-ray diffraction in the early twentieth century transformed crystallography from an area of scientific inquiry largely limited to physics, mineralogy, and mathematics, to a highly interdisciplinary field which now includes nearly all life and physical sciences as well as materials science and engineering. This book is a collection of works showcasing some of the most recent developments in the field of crystallography.

In the past few decades, the Finite Element Method (FEM) has been developed into a key indispensable technology in the modeling and simulation of various engineering systems. The present book reports on the state of the art research and development findings on this very broad matter through original and innovative research studies exhibiting various investigation directions of FEM in electrical, civil, materials and biomedical engineering. This book is a result of contributions of experts from international scientific community working in different aspects of FEM. The text is addressed not only to researchers, but also to professional engineers, students and other experts in a variety of disciplines, both academic and industrial seeking to gain a better understanding of what has been done in the field recently, and what kind of open problems are in this area.

This book comprises the contributions of several authors in the area of polymer physics by application of conducting polymers; hydrogel films on optical fiber core; thin film polymers; PDLC films application; photopolymers for holographic media; microwave absorption and EMI shielding behavior of nanocomposites based on intrinsically conducting polymers and graphene and carbon nanotubes; in the area of polymer synthesis of conducting polymers; oxidative polymerization of aniline; electro reductive polymerization; polysilanes with ordered sequences; radiation cross-linking poly(urethane-imide) and nitrogen-rich polymers as candidates for energetic applications; development of ruthenium complexes to novel functional nanocomposites. We hope that this book will help inspire readers to pursue study and research in this field.

This book has an aim to present latest applications, trends and developments of virtual reality technologies in three humanities disciplines: in medicine, psychology and pedagogy. Studies show that people in both educational as well as in the medical therapeutic range expect more and more that modern media are included in the corresponding demand and supply structures. For the Internet and various mobile media, associated research and application projects now have fixed key words such as "E-learning" and "E-Mental Health" or "M-Learning", "M-Mental Health". This book aims to contribute to the current state of the corresponding efforts in the area of ??further promising technology - the Virtual Reality - designed to give an overview and secondly to provide a stimulus on specific projects, associated with the hope of giving to scientists and practitioners from the humanities an impulse for their own (further-) development, evaluation and implementation of various VR scenarios in the education and health sectors.