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The aim of the present study was development and optimization of an efficacious, pharmaco-economical, palatable and marketable film coated tablet formulation of Norfloxacin-Tinidazole. Bitter taste of both drugs reduces the patient compliance & hence marketability. However it has been shown that film coating technology economical & useful in masking the taste. The core tablets with maximum hardness & minimum disintegration time were selected for film coating. (F-1 & F-07) The optimized formulation F-07 showed hardness, friability, disintegration time and drug release in range 9 kg/cm2, 0.17±0.02%, 27.40±2.1 sec. & 100% release in 30 min. respectively. For all tablet formulation drug release at the end of 30 min was found in the range of 52.78±0.09 to 100.07±0.5 % and from the obtained results, F-07 was selected as an optimized formulation for designing palatable tablet. Therefore it can be concluded that the present work discusses in depth the development and optimization of an efficacious, pharmaco-economical, palatable and marketable tablet formulation of Norfloxacin and Tinidazole.
This book is intended for dance teachers and students, who study classical ballet on a professional level and for amateurs as well. The author sorts out all rules and technical execution of basic movements in partnering for men and women as well. In examples of 10 lessons, he shows the sequence of studying elements of partnering with a detailed explanation of possible mistakes, with an analysis of relations between partners and with the guidance to invent an original choreography in duets.
NRF2 is a master regulator of the anti-oxidative stress response through controlling the expression of anti-oxidative stress response proteins and detoxifying enzymes. Cancer cells also exploit NRF2 protective functions to thrive and resist anti-tumor drugs. NRF2 is highly active in several types of human cancers and is associated with aggressiveness and metastasis. NRF2 affects many targets that are involved in hypoxia, angiogenesis, invasion, drug resistance, and epithelial-mesenchymal transition. NRF2 was found to be targeted by many microRNAs, so that it could be used as effective cancer therapy to improve the outcomes and contribute to the advancement of anti-tumor drugs.
Over the years, many people have tried to define alkaloids in different forms. Alkaloids are the most powerful than other phytochemicals. Here the author tried to explain the effectiveness of alkaloids, in which all substances that are poisonous in the plants are included. Therefore, it would be right to state that the exploits of any kind of alkaloids on the human body is naturally shocking and painful.
The success or failure of institutions to the success achieved by administrative leaders in their businesses, through the performance of roles and functions entrusted to them, and their contribution to the development of their organizations, according to their abilities and aptitudes enabling them to influence others to achieve their goals. Perhaps the era of change markedly in different aspects of life, and the associated information and technological revolution that swept through all organizations of all kinds, and the provision of technology innovative ways to accomplish the educational tasks, which changed the form of the educational process and its goal and create a highly competitive environment called organizations To pay close attention to the nature of efforts to accomplish the work, to maximize effectiveness by focusing on the efforts of teachers beyond the limits of official roles and requirements .
Many failures you face in your life, may throw you into a dark well. Sometimes you think it is better to leave the world. Sometimes these breaks keep you in the mud. There is no good feeling, and your mind is blocked.¿ The stories are about human suffering; the humans somehow, they have not any generic identity. Behind a person¿s suffering who is helpless and compelled, hide many feelings and experiences that show humanity and the man faces. Competitions, challenges, hard endeavors, and many hopes help you to grit your teeth, to continue your way, to obtain. The writer tries to wake up readers from the oppressions. Yet, although, she believes just when we have been deeply affected by human sufferings, we can change the world. For that is the case; we can find our abilities for justice and sympathy for each other.
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