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A comprehensive overview of important and contested issues in vaccination ethics and policy by experts from history, science, policy, law, and ethics. Vaccination has long been a familiar, highly effective form of medicine and a triumph of public health. Because vaccination is both an individual medical intervention and a central component of public health efforts, it raises a distinct set of legal and ethical issues--from debates over their risks and benefits to the use of government vaccination requirements--and makes vaccine policymaking uniquely challenging. This volume examines the full range of ethical and policy issues related to the development and use of vaccines in the United States and around the world. Forty essays, articles, and reports by experts in the field look at all aspects of the vaccine life cycle. After an overview of vaccine history, they consider research and development, regulation and safety, vaccination promotion and requirements, pandemics and bioterrorism, and the frontier of vaccination. The texts cover such topics as vaccine safety controversies; the ethics of vaccine trials; vaccine injury compensation; vaccine refusal and the risks of vaccine-preventable diseases; equitable access to vaccines in emergencies; lessons from the eradication of smallpox; and possible future vaccines against cancer, malaria, and Ebola. The volume intentionally includes texts that take opposing viewpoints, offering readers a range of arguments. The book will be an essential reference for professionals, scholars, and students. ContributorsJeffrey P. Baker, Seth Berkley, Luciana Borio, Arthur L. Caplan, R. Alta Charo, Dave A. Chokshi, James Colgrove, Katherine M. Cook, Louis Z. Cooper, Edward Cox, Douglas S. Diekema, Ezekiel J. Emanuel, Claudia I. Emerson, Geoffrey Evans, Ruth R. Faden, Chris Feudtner, David P. Fidler, Fiona Godlee, D. A. Henderson, Alan R. Hinman, Peter Hotez, Robert M. Jacobson, Aaron S. Kesselheim, Heidi J. Larson, Robert J. Levine, Donald W. Light, Adel Mahmoud, Edgar K. Marcuse, Howard Markel, Michelle M. Mello, Paul A. Offit, Saad B. Omer, Walter A. Orenstein, Gregory A. Poland, Lance E. Rodewald, Daniel A. Salmon, Anne Schuchat, Jason L. Schwartz, Peter A. Singer, Michael Specter, Alexandra Minna Stern, Jeremy Sugarman, Thomas R. Talbot, Robert Temple, Stephen P. Teret, Alan Wertheimer, Tadataka Yamada

A new analytical framework for understanding literary videogames, the literary-ludic spectrum, illustrated by close readings of selected works. In this book, Astrid Ensslin examines literary videogames--hybrid digital artifacts that have elements of both games and literature, combining the ludic and the literary. These works can be considered verbal art in the broadest sense (in that language plays a significant part in their aesthetic appeal); they draw on game mechanics; and they are digital-born, dependent on a digital medium (unlike, for example, conventional books read on e-readers). They employ narrative, dramatic, and poetic techniques in order to explore the affordances and limitations of ludic structures and processes, and they are designed to make players reflect on conventional game characteristics. Ensslin approaches these hybrid works as a new form of experimental literary art that requires novel ways of playing and reading. She proposes a systematic method for analyzing literary-ludic (L-L) texts that takes into account the analytic concerns of both literary stylistics and ludology. After establishing the theoretical underpinnings of her proposal, Ensslin introduces the L-L spectrum as an analytical framework for literary games. Based on the phenomenological distinction between deep and hyper attention, the L-L spectrum charts a work's relative emphases on reading and gameplay. Ensslin applies this analytical toolkit to close readings of selected works, moving from the predominantly literary to the primarily ludic, from online hypermedia fiction to Flash fiction to interactive fiction to poetry games to a highly designed literary "auteur" game. Finally, she considers her innovative analytical methodology in the context of contemporary ludology, media studies, and literary discourse analysis.

A detailed study of research on the psychology of expertise in weather forecasting, drawing on findings in cognitive science, meteorology, and computer science. This book argues that the human cognition system is the least understood, yet probably most important, component of forecasting accuracy. Minding the Weather investigates how people acquire massive and highly organized knowledge and develop the reasoning skills and strategies that enable them to achieve the highest levels of performance. The authors consider such topics as the forecasting workplace; atmospheric scientists' descriptions of their reasoning strategies; the nature of expertise; forecaster knowledge, perceptual skills, and reasoning; and expert systems designed to imitate forecaster reasoning. Drawing on research in cognitive science, meteorology, and computer science, the authors argue that forecasting involves an interdependence of humans and technologies. Human expertise will always be necessary.

An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules.Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility.The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after spines were first described by Ramón y Cajal, their function is still unclear. Dozens of different functions have been proposed, from Cajal's idea that they enhance neuronal interconnectivity to hypotheses that spines serve as plasticity machines, neuroprotective devices, or even digital logic elements. In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the "spine problem," searching for the fundamental function of spines. He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium compartmentalization. Yuste argues that we may never understand how the brain works without understanding the specific function of spines. In this book, he offers a synthesis of the information that has been gathered on spines (much of which comes from his own studies of the mammalian cortex), linking their function with the computational logic of the neuronal circuits that use them. He argues that once viewed from the circuit perspective, all the pieces of the spine puzzle fit together nicely into a single, overarching function. Yuste connects these two topics, integrating current knowledge of spines with that of key features of the circuits in which they operate. He concludes with a speculative chapter on the computational function of spines, searching for the ultimate logic of their existence in the brain and offering a proposal that is sure to stimulate discussions and drive future research.

Why dominant racial and gender groups have preferential access to jobs in computing, and how feminist labor activism in computing culture can transform the field into a force that serves democracy and social justice. Cracking the Bro Code is a bold ethnographic study of sexism and racism in contemporary computing cultures theorized through the analytical frame of the "Bro Code." Drawing from feminist anthropology and STS, Coleen Carrigan shares in this book the direct experiences of women, nonbinary individuals, and people of color, including her own experiences in tech, to show that computing has a serious cultural problem. From senior leaders in the field to undergraduates in their first year of college, participants consistently report how sexism and harassment manifest themselves in computing via values, norms, behaviors, evaluations, and policies. While other STEM fields are making strides in recruiting, retaining, and respecting women workers, computing fails year after year to do so. Carrigan connects altruism, computing, race, and gender to advance the theory that social purpose is an important factor to consider in working toward gender equity in computing. Further, she argues that transforming computing culture from hostile to welcoming has the potential to change not only who produces computing technology but also the core values of its production, with possible impacts on social applications. Cracking the Bro Code explains how digital bosses have come to operate imperiously in our society, dodging taxes and oversight, and how some programmers who look like them are enchanted with a sense of divine right. In the context of computing's powerful influence on the world, Carrigan speculates on how the cultural mechanisms sustaining sexism, harassment, and technocracy in computing workspaces impact both those harmed by such violence as well as society at large.

Essays that pay tribute to the wide-ranging influence of the late Herbert Simon, by friends and colleagues. Herbert Simon (1916-2001), in the course of a long and distinguished career in the social and behavioral sciences, made lasting contributions to many disciplines, including economics, psychology, computer science, and artificial intelligence. In 1978 he was awarded the Nobel Prize in economics for his research into the decision-making process within economic organizations. His well-known book The Sciences of the Artificial addresses the implications of the decision-making and problem-solving processes for the social sciences. This book (the title is a variation on the title of Simon's autobiography, Models of My Life) is a collection of short essays, all original, by colleagues from many fields who felt Simon's influence and mourn his loss. Mixing reminiscence and analysis, the book represents "a small acknowledgment of a large debt." Each of the more than forty contributors was asked to write about the one work by Simon that he or she had found most influential. The editors then grouped the essays into four sections: "Modeling Man," "Organizations and Administration," "Modeling Systems," and "Minds and Machines." The contributors include such prominent figures as Kenneth Arrow, William Baumol, William Cooper, Gerd Gigerenzer, Daniel Kahneman, David Klahr, Franco Modigliani, Paul Samuelson, and Vernon Smith. Although they consider topics as disparate as "Is Bounded Rationality Unboundedly Rational?" and "Personal Recollections from 15 Years of Monthly Meetings," each essay is a testament to the legacy of Herbert Simon--to see the unity rather than the divergences among disciplines.

How powerful new methods in nonlinear control engineering can be applied to neuroscience, from fundamental model formulation to advanced medical applications. Over the past sixty years, powerful methods of model-based control engineering have been responsible for such dramatic advances in engineering systems as autolanding aircraft, autonomous vehicles, and even weather forecasting. Over those same decades, our models of the nervous system have evolved from single-cell membranes to neuronal networks to large-scale models of the human brain. Yet until recently control theory was completely inapplicable to the types of nonlinear models being developed in neuroscience. The revolution in nonlinear control engineering in the late 1990s has made the intersection of control theory and neuroscience possible. In Neural Control Engineering, Steven Schiff seeks to bridge the two fields, examining the application of new methods in nonlinear control engineering to neuroscience. After presenting extensive material on formulating computational neuroscience models in a control environment--including some fundamentals of the algorithms helpful in crossing the divide from intuition to effective application--Schiff examines a range of applications, including brain-machine interfaces and neural stimulation. He reports on research that he and his colleagues have undertaken showing that nonlinear control theory methods can be applied to models of single cells, small neuronal networks, and large-scale networks in disease states of Parkinson's disease and epilepsy. With Neural Control Engineering the reader acquires a working knowledge of the fundamentals of control theory and computational neuroscience sufficient not only to understand the literature in this trandisciplinary area but also to begin working to advance the field. The book will serve as an essential guide for scientists in either biology or engineering and for physicians who wish to gain expertise in these areas.

An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical physiology and molecular biology. The authors cast a critical eye at current frameworks and practices, offer new recommendations for promoting recovery, and propose new research directions for the study of brain repair.Krakauer and Carmichael discuss such subjects as the behavioral phenotype of hand and arm paresis in human and non-human primates; the physiology and anatomy of the motor system after stroke; mechanisms of spontaneous recovery; the time course of early recovery; the challenges of chronic stroke; and pharmacological and stem cell therapies. They argue for a new approach in which patients are subjected to higher doses and intensities of rehabilitation in a more dynamic and enriching environment early after stroke. Finally they review the potential of four areas to improve motor recovery: video gaming and virtual reality, invasive brain stimulation, re-opening the sensitive period after stroke, and the application of precision medicine.

The seven-decade career of Howard Hiatt, a pioneer in public health, advocate for global health and health equity, a mentor to generations of healthcare leaders. Howard Hiatt--physician, scientist, advocate for global health, and mentor to generations of healthcare leaders--has spent much of his seven-decade career being ahead of his time. His innovative ideas as head of Harvard's School of Public Health from 1972 to 1984--about preventive medicine, the incorporation of cutting-edge science into the curriculum, and cross-disciplinary collaboration--met fierce resistance at the time but are now widely recognized building blocks of public health. Hiatt's interest in global health and health equity equipped him to advocate for a series of younger physicians and researchers, including Paul Farmer and Jim Kim, two founders of Partners in Health, and the prominent health policy expert Don Berwick. This book tells the story of Hiatt's life and work, with important lessons for today drawn from Hiatt's 92 years of experience. Hiatt, born in 1925, attended Harvard College and received an M.D. degree from Harvard Medical School. Before he headed the School of Public Health, he was a modernizing force as chief of medicine at Boston's Beth Israel Hospital. After his stormy tenure at SPH, he went to Brigham and Women's as a professor of medicine and a senior physician with a portfolio of his own devising. It was at the Brigham that Hiatt took on the role of mentor, influencing generations of physicians and staking out new territory in the fields of global health and clinical effectiveness. He is still active at 92 as teacher and mentor.

An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels.The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3-8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

Making the case that we can use nuclear power to combat climate change even as we reduce the risks of nuclear terror. Humanity faces two existential threats: nuclear annihilation and catastrophic climate change. Both have human origins, and both are linked to the use of nuclear energy. Inherent in the use of atomic fission is the risk that the technology and materials can be diverted to terrorists or hostile nations and used to make nuclear weapons. The key question is whether we can use nuclear energy to reduce the threat of climate change without increasing the risk that nuclear weapons will be used. In Double Jeopardy, Daniel Poneman argues that the world needs an "all-of-the-above" energy policy, one that advances the goal of decarbonizing the environment through all available means--including nuclear power. Poneman makes a compelling case that we can enhance the ability of nuclear power to combat climate change even as we reduce the risks of nuclear terror. Doing so will require well-crafted laws and policies, implemented with an ethos of constant vigilance and embedded in a culture that weaves safety and security goals into the fabric of our nuclear programs. This will enable government and industry to work together to maximize energy and climate benefits while minimizing safety and security risks.

Examinations of civic engagement in digital culture--the technologies, designs, and practices that support connection through common purpose in civic, political, and social life. Countless people around the world harness the affordances of digital media to enable democratic participation, coordinate disaster relief, campaign for policy change, and strengthen local advocacy groups. The world watched as activists used social media to organize protests during the Arab Spring, Occupy Wall Street, and Hong Kong's Umbrella Revolution. Many governmental and community organizations changed their mission and function as they adopted new digital tools and practices. This book examines the use of "civic media"--the technologies, designs, and practices that support connection through common purpose in civic, political, and social life. Scholars from a range of disciplines and practitioners from a variety of organizations offer analyses and case studies that explore the theory and practice of civic media.The contributors set out the conceptual context for the intersection of civic and media; examine the pressure to innovate and the sustainability of innovation; explore play as a template for resistance; look at civic education; discuss media-enabled activism in communities; and consider methods and funding for civic media research. The case studies that round out each section range from a "debt resistance" movement to government service delivery ratings to the "It Gets Better" campaign aimed at combating suicide among lesbian, gay, bisexual, transgender, and queer youth. The book offers a valuable interdisciplinary dialogue on the challenges and opportunities of the increasingly influential space of civic media.

Ralph Gomory and William Baumol adapt classical trade models to the modern world economy. In this book Ralph Gomory and William Baumol adapt classical trade models to the modern world economy. Trade today is dominated by manufactured goods, rapidly moving technology, and huge firms that benefit from economies of scale. This is very different from the largely agricultural world in which the classical theories originated. Gomory and Baumol show that the new and significant conflicts resulting from international trade are inherent in modern economies.Today improvement in one country's productive capabilities is often attainable only at the expense of another country's general welfare. The authors describe why and when this is so and why, in a modern free-trade environment, a country might have a vital stake in the competitive strength of its industries.

An exploration of moral stress, distress, and injuries inherent in modern society through the maps that pervade academic and public communications worlds. In Ethics in Everyday Places, ethicist and geographer Tom Koch considers what happens when, as he puts it, "you do everything right but know you've done something wrong." The resulting moral stress and injury, he argues, are pervasive in modern Western society. Koch makes his argument "from the ground up," from the perspective of average persons, and through a revealing series of maps in which issues of ethics and morality are embedded. The book begins with a general grounding in both moral stress and mapping as a means of investigation. The author then examines the ethical dilemmas of mapmakers and others in the popular media and the sciences, including graphic artists, journalists, researchers, and social scientists. Koch expands from the particular to the general, from mapmaker and journalist to the readers of maps and news. He explores the moral stress and injury in educational funding, poverty, and income inequality ("Why aren't we angry that one in eight fellow citizens lives in federally certified poverty?"), transportation modeling (seen in the iconic map of the London transit system and the hidden realities of exclusion), and U.S. graft organ transplantation. This uniquely interdisciplinary work rewrites our understanding of the nature of moral stress, distress and injury, and ethics in modern life. Written accessibly and engagingly, it transforms how we think of ethics--personal and professional--amid the often conflicting moral injunctions across modern society. Copublished with Esri Press

Interdisciplinary perspectives on the feature of conscious life that scaffolds every act of cognition: subjective time. Our awareness of time and temporal properties is a constant feature of conscious life. Subjective temporality structures and guides every aspect of behavior and cognition, distinguishing memory, perception, and anticipation. This milestone volume brings together research on temporality from leading scholars in philosophy, psychology, and neuroscience, defining a new field of interdisciplinary research.The book's thirty chapters include selections from classic texts by William James and Edmund Husserl and new essays setting them in historical context; contemporary philosophical accounts of lived time; and current empirical studies of psychological time. These last chapters, the larger part of the book, cover such topics as the basic psychophysics of psychological time, its neural foundations, its interaction with the body, and its distortion in illness and altered states of consciousness. ContributorsMelissa J. Allman, Holly Andersen, Valtteri Arstila, Yan Bao, Dean V. Buonomano, Niko A. Busch, Barry Dainton, Sylvie Droit-Volet, Christine M. Falter, Thomas Fraps, Shaun Gallagher, Alex O. Holcombe, Edmund Husserl, William James, Piotr Jaśkowski, Jeremie Jozefowiez, Ryota Kanai, Allison N. Kurti, Dan Lloyd, Armando Machado, Matthew S. Matell, Warren H. Meck, James Mensch, Bruno Mölder, Catharine Montgomery, Konstantinos Moutoussis, Peter Naish, Valdas Noreika, Sukhvinder S. Obhi, Ruth Ogden, Alan o'Donoghue, Georgios Papadelis, Ian B. Phillips, Ernst Pöppel, John E. R. Staddon, Dale N. Swanton, Rufin VanRullen, Argiro Vatakis, Till M. Wagner, John Wearden, Marc Wittmann, Agnieszka Wykowska, Kielan Yarrow, Bin Yin, Dan Zahavi

In this collection of essays and interviews from 1970-72, Jean-François Lyotard explores and drifts, as we drift, between art and politics, the "figural" and representation, silence and libidinal energy.

The derivation, exposition, and justification of the Selective Tuning model of vision and attention. Although William James declared in 1890, "Everyone knows what attention is," today there are many different and sometimes opposing views on the subject. This fragmented theoretical landscape may be because most of the theories and models of attention offer explanations in natural language or in a pictorial manner rather than providing a quantitative and unambiguous statement of the theory. They focus on the manifestations of attention instead of its rationale. In this book, John Tsotsos develops a formal model of visual attention with the goal of providing a theoretical explanation for why humans (and animals) must have the capacity to attend. He takes a unique approach to the theory, using the full breadth of the language of computation--rather than simply the language of mathematics--as the formal means of description. The result, the Selective Tuning model of vision and attention, explains attentive behavior in humans and provides a foundation for building computer systems that see with human-like characteristics. The overarching conclusion is that human vision is based on a general purpose processor that can be dynamically tuned to the task and the scene viewed on a moment-by-moment basis. Tsotsos offers a comprehensive, up-to-date overview of attention theories and models and a full description of the Selective Tuning model, confining the formal elements to two chapters and two appendixes. The text is accompanied by more than 100 illustrations in black and white and color; additional color illustrations and movies are available on the book's Web site.

"A guide for managers to make their organizations more conducive to job crafting by employees"--

"This book explores the work of activists in the Americas who are documenting feminicide, arguing that feminist activists at the margins have much to teach mainstream data scientists about data ethics: how to work with data ethically amidst extreme and durable structural inequalities"--

"How cultural and technological objects can reveal more information than their creators or sharers intended, or even imagined, when introduced into new contexts"--

"The definitive work on Robert Beavers by the only scholar with full access to his archive; a lavishly illustrated, beautifully written insider account of one of today's great avantgarde filmmakers"--

"Originally published as Spritzen: Geschichte der weiblichen Ejakulation, Edition Nautilus GmbH 2019."

A man and his equation: the anxiety-plagued nineteenth-century physicist who contributed significantly to our understanding of the second law of thermodynamics. Ludwig Boltzmann's grave in Vienna's Central Cemetery bears a cryptic epitaph: S = k log W. This equation was Boltzmann's great discovery, and it contributed significantly to our understanding of the second law of thermodynamics. In Anxiety and the Equation, Eric Johnson tells the story of a man and his equation: the anxiety-plagued nineteenth-century physicist who did his most important work as he struggled with mental illness. Johnson explains that "S" in Boltzmann's equation refers to entropy, and that entropy is the central quantity in the second law of thermodynamics. The second law is always on, running in the background of our lives, providing a way to differentiate between past and future. We know that the future will be a state of higher entropy than the past, and we have Boltzmann to thank for discovering the equation that underlies that fundamental trend. Johnson, accessibly and engagingly, reassembles Boltzmann's equation from its various components and presents episodes from Boltzmann's life--beginning at the end, with "Boltzmann Kills Himself" and "Boltzmann Is Buried (Not Once, But Twice)." Johnson explains the second law in simple terms, introduces key concepts through thought experiments, and explores Boltzmann's work. He argues that Boltzmann, diagnosed by his contemporaries as neurasthenic, suffered from an anxiety disorder. He was, says Johnson, a man of reason who suffered from irrational concerns about his work, worrying especially about opposition from the scientific establishment of the day. Johnson's clear and concise explanations will acquaint the nonspecialist reader with such seemingly esoteric concepts as microstates, macrostates, fluctuations, the distribution of energy, log functions, and equilibrium. He describes Boltzmann's relationships with other scientists, including Max Planck and Henri Poincaré, and, finally, imagines "an alternative ending," in which Boltzmann lived on and died of natural causes.

An overview of the mechanisms and evolution of spatial cognition, integrating evidence from psychology, neuroscience, cognitive science, and computational geometry. Understanding how we deal with space requires input from many fields, including ethology, neuroscience, psychology, cognitive science, linguistics, geography, and spatial information theory. In From Geometry to Behavior, cognitive neuroscientist Hanspeter A. Mallot provides an overview of the basic mechanisms of spatial behavior in animals and humans, showing how they combine to support higher-level performance. Mallot explores the biological mechanisms of dealing with space, from the perception of visual space to the constructions of large space representations: that is, the cognitive map. The volume is also relevant to the epistemology of spatial knowledge in the philosophy of mind. Mallot aims to establish spatial cognition as a scientific field in its own right. His general approach is psychophysical, in that it focuses on quantitative descriptions of behavioral performance and their real-world determinants, thus connecting to the work of theorists in computational neuroscience, robotics, and computational geometry. After an overview of scientific thinking about space, Mallot covers spatial behavior and its underlying mechanisms in the order of increasing memory involvement. He describes the cognitive processes that underlie advanced spatial behaviors such as directed search, wayfinding, spatial planning, spatial reasoning, object building and manipulation, and communication about space. These mechanisms are part of the larger cognitive apparatus that also serves visual and object cognition; understanding events, actions, and causality; and social cognition, which includes language. Of all of these cognitive domains, spatial cognition most likely occurred first in the course of evolution and is the most widespread throughout the animal kingdom.

An analysis of advances in military technology that illustrates the importance of organizational flexibility in both an attacker's innovations and an opponent's adaptations. How important is military innovation in determining outcomes during armed conflict? In Innovation and Adaptation in War, Matthew Tattar questions the conventional wisdom that, to succeed, military organizations must innovate early and often. Because successful methods of warfare are soon widely imitated or countered on the international stage, the advantages of a particular innovation quickly evaporate. Therefore, Tattar argues, large-scale innovations at the cost of organizational flexibility and the ability to adapt to an adversary's innovations may not be the optimal path--not just because force readiness is vital but also because innovation does not provide as long-lasting and decisive an advantage as may have been previously thought. Although other scholars have analyzed the sources of military innovation, Tattar is the first to focus on the relationship between innovation and specific military outcomes. Looking at several different types of military organizations and many different types of battles, he draws on theoretical works, in-depth historical research, and case studies, and finds that the initial advantages that are generated by innovation disappear far too rapidly in wartime for militaries to depend on them for victory. Furthermore, as Tattar demonstrates, emphasizing innovation in defense planning at the expense of organizational flexibility can have significant negative consequences. The decisive factor in successful adaptation, more often than not, is a well-positioned and flexible organization. Providing both a new framework for studying military innovation and a comprehensive review of the current literature in this field, Innovation and Adaptation in War offers crucial policy-making insights into when and under what circumstances militaries should innovate and adapt.

Scholars consider the origins and consequences of the evolution of multicellularity, addressing a range of organisms, experimental protocols, theoretical concepts, and philosophical issues. The evolution of multicellularity raises questions regarding genomic and developmental commonalities and discordances, selective advantages and disadvantages, physical determinants of development, and the origins of morphological novelties. It also represents a change in the definition of individuality, because a new organism emerges from interactions among single cells. This volume considers these and other questions, with contributions that explore the origins and consequences of the evolution of multicellularity, addressing a range of topics, organisms, and experimental protocols.Each section focuses on selected topics or particular lineages that present a significant insight or challenge. The contributors consider the fossil record of the paleontological circumstances in which animal multicellularity evolved; cooptation, recurrent patterns, modularity, and plausible pathways for multicellular evolution in plants; theoretical approaches to the amoebozoa and fungi (cellular slime molds having long provided a robust model system for exploring the evolution of multicellularity), plants, and animals; genomic toolkits of metazoan multicellularity; and philosophical aspects of the meaning of individuality in light of multicellular evolution.ContributorsMaja Adamska, Argyris Arnellos, Juan A. Arias, Eugenio Azpeitia, Mariana Benítez, Adriano Bonforti, John Tyler Bonner, Peter L. Conlin, A. Keith Dunker, Salva Duran-Nebreda, Ana E. Escalante, Valeria Hernández-Hernández, Kunihiko Kaneko, Andrew H. Knoll, Stephan G. König, Daniel J. G. Lahr, Ottoline Leyser, Alan C. Love, Raul Montañez, Emilio Mora van Cauwelaert, Alvaro Moreno, Vidyanand Nanjundiah, Aurora M. Nedelcu, Stuart A. Newman, Karl J. Niklas, William C. Ratcliff, Iñaki Ruiz-Trillo, Ricard Solé

An engaging and insightful journey into human consciousness. What if our goal had not been to land on Mars, but in pure consciousness? The experience of pure consciousness--what does it look like? What is the essence of human consciousness? In The Elephant and the Blind, influential philosopher Thomas Metzinger, one of the world's leading researchers on consciousness, brings together more than 500 experiential reports to offer the world's first comprehensive account of states of pure consciousness. Drawing on a large psychometric study of meditators in 57 countries, Metzinger focuses on "pure awareness" in meditation--the simplest form of experience there is--to illuminate the most fundamental aspects of how consciousness, the brain, and illusions of self all interact. Starting with an exploration of existential ease and ending on Bewusstseinskultur, a culture of consciousness, Metzinger explores the increasingly non-egoic experiences of silence, wakefulness, and clarity, of bodiless body-experience, ego-dissolution, and nondual awareness. From there, he assembles a big picture--the elephant in the parable, from which the book's title comes--of what it would take to arrive at a minimal model explanation for conscious experience and create a genuine culture of consciousness. Freeing pure awareness from new-age gurus and old religions, The Elephant and the Blind combines personal reports of pure consciousness with incisive analysis to address the whole consciousness community, from neuroscientists to artists, and its accessibility echoes the author's career-long commitment to widening access to philosophy itself.

A framework for macroprudential regulation that defines systemic risk and macroprudential policy, describes macroprudential tools, and surveys the effectiveness of existing macroprudential regulation.