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At any one time, at least 30,000 people in the U.S. are living with amyotrophic lateral sclerosis (ALS), a rapidly progressive, fatal neurological disease affecting individuals, caregivers, at-risk genetic carriers, and others. In 2022, Congress directed the National Institutes of Health to commission a National Academies committee of experts to recommend key actions public, private, and nonprofit sectors should take to make ALS a livable disease within the next 10 years. The resulting report, Living with ALS, focuses on an integrated ALS multidisciplinary care and research system to help facilitate earlier diagnosis and connections to specialty care.

The future safety of maritime transportation in the United States-a major factor in the nation's international trade and economic well-being-will depend heavily on the quality of port and waterways information systems. Many U.S. ports and waterways lack adequate information services, although certain elements of advanced systems are now available in some locations. Barriers to improvements in information systems include the division of responsibilities for waterways management among multiple agencies at all levels of government, a lack of coordination among the federal agencies responsible for waterways management, inadequate budgets for some critical maritime programs, the high costs of some specialized technologies, stakeholder opposition to user fees, limited access to certain key data, the incompatibility of many independently developed systems, and the absence of standards for some attractive technologies.In this report, the second phase of a three-year study by the Committee on Maritime Advanced Information Systems of the National Research Council, a strategy is presented for overcoming the major barriers and deficiencies and providing a minimum level of maritime safety information nationwide. In this phase of the study, the committee concentrated on maritime information systems that promote safety, which is the area of greatest need. The committee did not examine in detail the relationship between navigation safety and maritime transportation efficiency or evaluate information systems that promote efficiency; the committee believes, however, that these issues deserve further attention.

In 1997, the Congress directed the NRC to carry out a series of assessments of project management at the Department of Energy (DOE). The final part of that series, this report presents an examination of DOE's progress in improving program management, including the Department's response to recommendations of the previous assessments in the series.

Provides a plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community.

The granting of offsets to promote exports of major aircraft systems has been a source of significant controversy. Critics believe that offsets undermine the U.S. manufacturing base; lead to the transfer of commercial technology, possibly affecting national security; and result in the loss of high-wage jobs. Defenders of the practice argue that offsets are a fact of commercial life and can result in net U.S. job gains.In an effort to focus the offsets debate on analytical issues, the White House National Economic Council asked the National Research Council to convene expert academicians, representatives from the aerospace industry, and top government officials to discuss the impact of offsets on the U.S. economy. To ensure a rigorous discussion encompassing all points of view, the conference included a series of papers outlining the positions of key participants. This resulting volume offers a comprehensive and up-to-date analysis of the impact of aerospace offsets.

The commercial aviation industry is a major part of the U.S. transportation infrastructure and a key contributor to the nation's economy. The industry is facing the effects of a reduced role by the military as a source of high-quality trained personnel, particularly pilots and mechanics. At the same time, it is facing the challenges of a changing American workforce.This book is a study of the civilian training and education programs needed to satisfy the work-force requirements of the commercial aviation industry in the year 2000 and beyond, with particular emphasis on issues related to access to aviation careers by women and minorities.

Chemical signals among organisms form "e;a vast communicative interplay, fundamental to the fabric of life,"e; in the words of one expert. Chemical ecology is the the discipline that seeks to understand these interactions-to use biology in the search for new substances of potential benefit to humankind.This book highlights selected research areas of medicinal and agricultural importance. Leading experts review the chemistry ofInsect defense and its applications to pest control.Phyletic dominance--the survival success of insects.Social regulation, with ant societies as a model of multicomponent signaling systems.Eavesdropping, alarm, and deceit--the array of strategies used by insects to find and lure prey.Reproduction--from the gamete attraction to courtship nd sexual selection.The chemistry of intracellular immunosuppression.Topics also include the appropriation of dietary factors for defense and communication; the use of chemical signals in the marine environment; the role of the olfactory system in chemical analysis; and the interaction of polydnaviruses, endoparasites, and the immune system of the host.

Despite the strong safety record of the national airspace system, serious disruptions occasionally occur, often as a result of outdated or failed equipment. Under these circumstances, safety relies on the skills of the controllers and pilots and on reducing the number of aircraft in the air. The current and growing pressures to increase the capacity to handle a greater number of flights has led to a call for faster and more powerful equipment and for equipment that can take over some of the tasks now being performed by humans. Increasing the role of automation in air traffic control may provide a more efficient system, but will human controllers be able to effectively take over when problems occur? This comprehensive volume provides a baseline of knowledge about the capabilities and limitations of humans relative to the variety of functions performed in air traffic control. It focuses on balancing safety with the expeditious flow of air traffic, identifying lessons from past air accidents. The book discussesThe function of the national airspace system and the procedures for hiring, training, and evaluating controllers.Decisionmaking, memory, alertness, vigilance, sleep patterns during shift work, communication, and other factors in controllers' performance.Research on automation and human factors in air traffic control and incorporation of findings into the system.The Federal Aviation Administration's management of the air traffic control system and its dual mandate to promote safety and the development of air commerce.This book also offers recommendations for evaluation the human role in automated air traffic control systems and for managing the introduction of automation into current facilities and operations. It will be of interest to anyone concerned about air safety--policymakers, regulators, air traffic managers and controllers, airline officials, and passenger advocates.