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Inflammatory markers, oncogenes, tumor suppressor genes and cell cycle regulators in skin growths represent a series of reports and reviews on skin cancers and precancers, their host immune responses and correlations with medical literature data. We were able to clearly identify an immune response in multiple skin cancers, as well as in cutaneous pre-cancerous conditions. In poorly differentiated tumor areas, some classic immunohistochemical stains did not stain as frequently described in the literature. Other important phenomena we observed are that many cell cycle regulators, cell cycle checkpoints, oncogenes and tumor suppressor gene markers were not only positive inside the tumors, but also in cells around the tumor. Portions of adjacent skin appendices and in supposedly normal adjacent epidermal and dermal tissue also showed signs of these components. These common findings raised questions concerning marginal definition of cutaneous surgery; that is, many of the immunologic findings could not be correlated on classical hematoxylin and eosin reviews. We also noted that many immunologic cells around skin cancers and/or pre-cancers showed high rates of division defined via markers such as Ki-67; our findings utilizing double color immunohistochemistry also showed that these immune cells are possibly actively duplicating as effector cells. Ki-67 has been cited as a superb proliferation marker in melanoma, but additional review of its utility is warranted given our results. Finally, we also found double staining immunohistochemistry to be of excellent value in detecting melanoma cells metastasizing in blood vessels, lymphatics and/or nerves.

The purpose of this book is to provide a broad background of several aspects of basic sciences, clinical, therapeutic aspects, and management of endometrial cancer. It provides state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the endometrium and endometrial cancer. The descriptive and analytical epidemiology of endometrial cancer are presented in Chapter 1. The pathology and molecular diagnosis of endometrial cancer are discussed in Chapter 2. The molecular pathology of endometrial cancer is detailed in Chapter 3. The hereditary aspect of endometrial cancer is highlighted in Chapter 4. Precancerous lesions of the endometrium are reviewed in detail in Chapter 5. Endometrial biomarkers are detailed in Chapter 6. Lymphatic mapping of endometrial cancer is discussed in Chapter 7. Sentinel lymph nodes in endometrial cancer are highlighted in Chapter 8. The current strategies and approaches to treat patients with endometrial cancer are detailed in Chapter 9. Surgical techniques for endometrial cancer are reviewed in Chapter 10. The current treatment of advanced endometrial cancer is discussed in Chapter 11. Adjuvant medical therapeutic modalities are reviewed in Chapter 12. Targeted therapies for advanced endometrial cancer are presented in Chapter 13. The role of ErbB targeted therapy in treating endometrial cancer is discussed in Chapter 14. Finally, the quality of life of women with endometrial cancer is reviewed in Chapter 15. This book is intended for all clinicians and basic medical scientists caring for women with endometrial cancer, including attending surgeons and physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology, as well as PhD students and post-doctoral fellows in the basic medical sciences.

The perineal nature, huge foliage and extensive root system of fruit crops offer conducive conditions for survival and colonization of plant pathogens. Plant diseases in fruit crops are of common occurrence and account for up to 10-20% yield losses. The present book embodies 18 chapters covering major diseases of important temperate fruit crops (almond, apple, apricot, cherry, peach, pear, pistachio, plums, strawberry, walnut, etc.), subtropical and tropical fruit crops (aonla, avocado, bael, banana, cashew, citrus, fig, grapes, guava, jackfruit, jamun, jujube, kiwi, litchi, loquat, mango, papaya, passion-fruit, pineapple, pomegranate, sapota, etc.) and plantation crops (Coconut, Coffee, Date palm, Oil palm, Rubber, Tea, etc.), highlighting the aetiology, symptoms, disease cycle, economic importance, distribution, and management aspects with advanced and sustainable approaches. The present book shall serve as an important reference source to UG/PG students, academics, professionals, scientists, researchers and extension personnel dealing with plant diseases in universities and institutes, bureaus, directorates, research stations etc.

This work includes details starting from the basics of drone technology and discusses diverse aspects related to drone designing and implementation. Further chapters detail the impact of drone technology on society in terms of development, challenges, and security concerns. Then, implementations of artificial intelligence techniques such as machine learning, deep learning, etc., are discussed to translate drone technology into intelligent drone technology. There are diverse applications in the area of intelligent drone technologies such as agriculture, disaster management, security, military, etc. Hence, in this book, some of the drone-specific applications are discussed.