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In Horizons in Cancer Research. Volume 76, the molecular drivers associated with prostate cancers at different stages which can be exploited as drug targets are discussed. This information will be useful for designing rational targeted therapeutic strategies for treatment of this disease. Following this, the authors discuss lung cancer early diagnosis with traditional and alternative approaches. In lung cancer, smoking exposure has been identified as the main causative agent in smokers. A critical appraisal of the different updated techniques in the mediastinal staging of lymph nodes in lung cancer is provided. The authors also provide an overview of colorectal cancer and Ca2+ signalling in cells, focusing their discussion on a specific component of the Ca2+ signalling machinery, the transient receptor potential cation channel subfamily V member 4 channel. Breast cancer, a serious public health problem, is assessed, maintaining that women need accurate and effective information in order to attain early diagnosis. Lastly, a simple technique to decreases cell-culture pH while maintaining sterile technique is described.
In Health Sciences it is necessary to have measuring instruments that allow analyzing various phenomena for better understanding, including those related to human sexuality. Undoubtedly, it is a sensitive issue to discuss, so it is important to have empirical indicators that are capable of measuring as accurately as possible concepts that interest researchers. The book Validation of instruments for the investigation of sexuality in vulnerable groups is written with the purpose of guiding the process of adaptation and validation of various instruments in the field of sexuality step by step to researchers, teachers and students This is a book that can be used in basic, intermediate and advanced research courses, as well as in research seminars or on methodology. It contains various validated instruments that make it useful for any area of health science and social science. This book collects, updates and analyzes the instruments currently available for the measurement of sexual health, provides a detailed guide to the questionnaires prepared, translated and validated so that health professionals can choose the instrument to use according to the subject of interest. Also, the information provided could be useful to researchers who want to know how to validate an instrument and consider carrying out research studies on issues related to human sexuality. To facilitate understanding, conceptual references related to the methodological design and the study phenomenon are included.
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