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New techniques - notably Scarf, the first metatarsal osteotomy and the Weil osteotomy of the lesser metatarsal - provide a significant improvement in the treatment of static forefoot disorders.

Pushed by the progress of biology, technology and biomechanics, knee surgery has dramatically evolved in the last decades. This book is a "state of the art" concerning all aspects of knee surgery from ligament reconstruction to Total Knee Arthroplasty.

This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compoundscurrently under evaluation.

This book examines the phylontogenic theory, which seeks early evolutionary signs of the olfactory organ and traces its transformations through respiratory apparatus to the central point of human facial anatomy. Offers insight into nose and sinus diseases.

It has by now been established that carpal ligamentary lesions may lead to instability and ultimately to carpal arthritis.

The purpose of this book is to define the basis of telemicrosurgery, a new discipline at the border of robotics and microsurgery. After the history of robotics and microsurgery, the robots and their instrumentation will be described. The chapters will explain the training in telemicrosurgery and then propose some experimental paradigms.

The focus is on basic information on every orthopedic subspecialty, including: surgical anatomy, basic sciences, adult reconstruction, pediatric orthopedics, foot and ankle surgery, orthopedic pathology, the spine, sports surgery, upper limb, wrist and hand surgery, and orthopedic traumas.

The Galdakao-modified supine Valdivia position allowed the development of ECIRS (Endoscopic Combined IntraRenal Surgery), a technique exploiting a combined antegrade and retrograde approach to the upper urinary tract, using both rigid and flexible endoscopes with the related accessories.

The comfortable boundaries of static architectures and well-defined limits and owners are not existent in these AmI ecosystems. In its second year AmI.d again shows the heterogeneity of research challenges related to Ambient Intelligence.

Early Puberty

The first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course, this heavily-illustrated text covers all surgical aspects from anatomy and imaging to techniques and pathologies.

The first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course, this heavily-illustrated text covers all surgical aspects from anatomy and imaging to techniques and pathologies.

Dr Buzdar presented a history and overview of the protection of human subjects who participate in clinical research, and the mechanisms developed to assure the ethical conduct of research on human beings.

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas.

A radiologist, who wants to acquire a PACS, or a mathematician asking for pertinent applications of image processing techniques will find recent information guiding their choice in research or in acquisition of imaging or computing devices of a hospital information system.

International Congress for Infectious Diseases, Rio de Janeiro - April 17-21, 1988. F.-A. Waldvogel, President

Classification of the carpal injuries helps us to understand the relationship between them. The growing interest in this field has been advanced by recent imaging techniques. Therapeutic advice and treatment are still not completely defined, even by the most renowned specialists. There is still room for new concepts.

Tumors cells no longer confined to an affected organ can be released through lymph and the blood stream, disseminate and form metastases. The dinical evaluation as weIl as to tumor pathophysiology are weIl explai ned in two general chapters and then each specific primary tumor is analyzed in a specific chapter.

Oral medical communication involves taking the floor to speak, whether it be as a speaker, the person who gives the talk in front of an audience, or as part of the audience, who can then ask questions or make comments.

Les mA(c)thodes spectrales sont une technique rA(c)cente d'approximation de la solution d'A(c)quations aux dA(c)rivA(c)es partielles par des polynAmes de haut degrA(c). Elles ont un degrA(c) de prA(c)cision infini: l'ordre de l'erreur ne dA(c)pend que de la solution A approcher. Leur utilisation s'est A(c)normA(c)ment dA(c)veloppA(c)e ces derniA]res annA(c)es. Le sujet de ce livre est l'analyse numA(c)rique des mA(c)thodes spectrales. Il prA(c)sente de faAon unifiA(c)e les notions de base, parmi lesquelles certains rA(c)sultats rA(c)cents, et donne quelques applications (en particulier la discrA(c)tisation du problA]me de Stokes). Une attention particuliA]re est portA(c)e A l'optimalitA(c) des rA(c)sultats, dA(c)montrA(c)e grA[ce A des contre-exemples appropriA(c)s. La lecture du livre permet aux A(c)tudiants de D.E.A. d'analyse numA(c)rique et aux chercheurs intA(c)ressA(c)s par le sujet d'acquA(c)rir une connaissance complA]te de la mA(c)thode pour des problA]mes modA]le, ainsi que les idA(c)es de base permettant de la mettre en A"uvre. Un formulaire regroupe les formules de base sur les polynAmes orthogonaux pour faciliter la lecture. L'ouvrage contient des nombreux exercices.

From anesthesia to post-surgery recovery procedures, this book presents all the steps necessary to complete a stereotaxic neurosurgery protocol on rodents in accordance with current animal welfare guidelines.

Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible.

From cutaneous signs to the richness of differential diagnosis, this book guides practitioners through every step from semiological analysis to diagnosis. It provides readers with the keys of relevant dermatological reasoning.