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This volume emphasizes the diversity and fruitfulness of early modern mechanism as a program, as a concept, as a model. Mechanistic study of the living body but also of the mind and mental processes are examined in careful historical focus, dealing with figures ranging from the first-rank (Bacon, Descartes, Spinoza, Cudworth, Gassendi, Locke, Leibniz, Kant) to less well-known individuals (Scaliger, Martini) or prominent natural philosophers who have been neglected in recent years (Willis, Steno, etc.). The volume moves from early modern medicine and physiology to late Enlightenment and even early 19th-century psychology, always maintaining a conceptual focus. It is a contribution to a newly active field in the history and philosophy of early modern life science. It is of interest to scholars studying the history of medicine and the development of mechanistic theories.

This book traces raciolinguistic ideologies in England's schools, focusing on post- 2010 policy reforms which frame the language practices of low-income, racialised speakers as limited and deficient. Across interviews, policy mechanisms and classroom observations, the author shows how raciolinguistic ideologies are rooted in British colonial logics which continue to shape contemporary education policy. He shows how these policies require marginalised speakers to modify their speech patterns in line with normative standards of whiteness under new guises of social justice and research robustness. Finally, new visions for language education and linguistic justice are offered, demonstrating how teachers can see themselves as language activists to identify, resist and reject faults in a hostile and oppressive policy architecture. This book draws on fields including critical language policy, educational sociolinguistics, genealogy, raciolinguistics and critical language awareness.

This edited book examines the multilingual culture of medieval England, exploring its impact on the development of English and its textual manifestations from a multi-disciplinary perspective. The book offers overviews of the state of the art of research and case studies on this subject in (sub)disciplines of linguistics including historical linguistics, onomastics, lexicology and lexicography, sociolinguistics, code-switching and language contact, and also includes contributions from literary and socio-cultural studies, material culture, and palaeography. The authors focus on the variety of languages in use in medieval Britain, including English, Old Norse, Norn, Dutch, Welsh, French, and Latin, making the argument that understanding the impact of medieval multilingualism on the development of English requires multidisiplinarity and the bringing together of different frameworks in linguistics and cultural studies toachieve more nuanced answers. This book will be of interest to academics and students of historical linguistics and medieval textual culture.

This book presents explainability in edge AI, an amalgamation of edge computing and AI. The issues of transparency, fairness, accountability, explainability, interpretability, data-fusion, and comprehensibility that are significant for edge AI are being addressed in this book through explainable models and techniques. The concept of explainable edge AI is new in front of the academic and research community, and consequently, it will undoubtedly explore multiple research dimensions. The book presents the concept of explainability in edge AI which is the amalgamation of edge computing and AI. In the futuristic computing scenario, the goal of explainable edge AI will be to execute the AI tasks and produce explainable results at the edge. First, this book explains the fundamental concepts of explainable artificial intelligence (XAI), then it describes the concept of explainable edge AI, and finally, it elaborates on the technicalities of explainability in edge AI. Owing to the quick transition in the current computing scenario and integration with the latest AI-based technologies, it is significant to facilitate people-centric computing through explainable edge AI. Explainable edge AI will facilitate enhanced prediction accuracy with the comprehensible decision and traceability of actions performed at the edge and have a significant impact on futuristic computing scenarios. This book is highly relevant to graduate/postgraduate students, academicians, researchers, engineers, professionals, and other personnel working in artificial intelligence, machine learning, and intelligent systems.

This book develops integral identities, mostly involving multidimensional functions and infinite limits of integration, whose evaluations are intractable by common means. It exposes a methodology based on the multivariate power substitution and its variants, assisted by the software tool Mathematica. The approaches introduced comprise the generalized method of exhaustion, the multivariate power substitution and its variants, and the use of permutation symmetry to evaluate definite integrals, which are very important both in their own right, and as necessary intermediate steps towards more involved computation.A key tenet is that such approaches work best when applied to integrals having certain characteristics as a starting point. Most integrals, if used as a starting point, will lead to no result at all, or will lead to a known result. However, there is a special class of integrals (i.e., innovative integrals) which, if used as a starting point for such approaches, will lead to new and useful results, and can also enable the reader to generate many other new results that are not in the book.The reader will find a myriad of novel approaches for evaluating integrals, with a focus on tools such as Mathematica as a means of obtaining useful results, and also checking whether they are already known. Results presented involve the gamma function, the hypergeometric functions, the complementary error function, the exponential integral function, the Riemann zeta function, and others that will be introduced as they arise. The book concludes with selected engineering applications, e.g., involving wave propagation, antenna theory, non-Gaussian and weighted Gaussian distributions, and other areas.The intended audience comprises junior and senior sciences majors planning to continue in the pure and applied sciences at the graduate level, graduate students in mathematics and the sciences, and junior and established researchers in mathematical physics, engineering, and mathematics. Indeed, the pedagogical inclination of the exposition will have students work out, understand, and efficiently use multidimensional integrals from first principles.

This volume highlights the potentials as well as the limits and challenges of human breath analysis and describes the current efforts made to advance this promising technology from bench to bed. Human breath analysis is a young, interdisciplinary and innovative research field aiming to provide a smart and non-invasive diagnostic tool, which can be used for screening, detecting and monitoring of diseases or metabolic disorders. This book presents different approaches for breath analysis including real-time and offline mass spectrometry as well as optical and semiconductor gas sensing methods. Besides, the role of smart algorithms to improve the performance of those technologies and the importance of pulmonary function diagnostics for more reliable and meaningful breath analysis are highlighted. Finally, current application scenarios and future perspectives of breath analysis and pulmonary functioning tests are addressed.The volume is useful for researchers, who are new in the field, to easily get an overview of the current status and the challenges present in human breath analysis. Topics from fundamental research over targeted sensor development and application scenarios are described. Thus, this volume covers all development stages providing support and inspiration for engineers, medical doctors and scientists from various fields.

Studies on South Asia are an emerging interdisciplinary field, this volume expands on the currently limited literature available on South Asia and focuses on the regions environmental, climatic and natural resource base by looking at case studies from Nepal, India and Bangladesh. The book contains twelve chapters which deal with various environmental challenges, such as the impacts of climate change on floods and droughts, population structure and regeneration dynamics of dominant  treeline species, environmental changes and rural livelihoods, and change analysis and impacts of hard coastal structures. Apart from the various thematic areas and diversity of geographical coverage, most of the studies also demonstrate the application of geospatial techniques for the collection of environmental data, and the use of GIS for spatial analysis of the data. The specific application of geospatial techniques and methods includes NDVI, NDWI, NDBI, SMI, SPOT-VGT NDVI, environmental flow, distribution and trend estimation of tropospheric formaldehyde, vegetation sensitivity to climate change, variability of tropospheric  ozone, and geo-environmental problems.The contributors are seasoned researchers currently engaged in  academic and research activities, and work at universities  in USA, India, Bangladesh, Bhutan and Japan.

This book introduces a variety of well-proven and newly developed nature-inspired optimization algorithms solving a wide range of real-life biomedical and healthcare problems. Few solo and hybrid approaches are demonstrated in a lucid manner for the effective integration and finding solution for a large-scale complex healthcare problem. In the present bigdata-based computing scenario, nature-inspired optimization techniques present adaptive mechanisms that permit the understanding of complex data and altering environments. This book is a voluminous collection for the confront faced by the healthcare institutions and hospitals for practical analysis, storage, and data analysis. It explores the distinct nature-inspired optimization-based approaches that are able to handle more accurate outcomes for the current biomedical and healthcare problems. In addition to providing a state-of-the-art and advanced intelligent methods, it also enlightens an insight for solving diversified healthcare problems such as cancer and diabetes.

Written by the leading experts of this field, this book results from the International Symposium on "e;Single Molecule Machines on a Surface: Gears, Train of Gears, Motors, and Cars"e; which took place in Toulouse, France on November 24th - 25th, 2021. The different chapters focus on describing the use of single molecule mechanics on a surface and analyze the different steps leading to the design of a single molecule nanocar. The authors present how a single molecule is rotating, how a single molecule gear can participate to a train of molecule gears to propagate motion and how this knowledge is used for the design of nanocars. The way energy is provided to a single molecule and how this energy drives it onto the surface is also analyzed. A large portion of this volume is written by the eight teams selected to participate in the Nanocar Race II event. This book is of great use to graduate students, post-doctoral fellows and researchers who are interested in single molecule mechanics and who want to know more about the fundamentals and applications of this new research field. 

This book provides a comprehensive introduction to the Calculus of Variations and its use in modelling mechanics and physics problems. Presenting a geometric approach to the subject, it progressively guides the reader through this very active branch of mathematics, accompanying key statements with a huge variety of exercises, some of them solved. Stressing the need to overcome limitations of the initial point of view, and emphasising the interconnectivity of various branches of mathematics (algebra, analysis and geometry), the book includes some advanced material to challenge the most motivated students. Systematic, short historical notes provide details on the subject's odyssey, and how new tools have been developed over the last two centuries. This English translation updates a set of notes for a course first given at the Ecole polytechnique in 1987. It will be accessible to graduate students and advanced undergraduates.

Introducing the institutional logics perspective to street-level analysis, this book examines how street-level workers deal with the institutional logics that guide their organization - whether they follow or challenge them. While doing so, the book develops a theoretical framework to study street-level workers' institutional agency within organizations from different institutional backgrounds. The book conceptualizes street-level workers as institutional entrepreneurs and presents an original process model to capture deinstitutionalization efforts in street-level discourse. This ordinal model accounts for embedded agency and institutional entrepreneurship as well as for more gradual moves towards deinstitutionalization through the hybridization of institutional logics. The author tests the model empirically using interview data and discusses how street-level workers diverge from the institutional logic of their organization in almost two thirds of their statements, indicating a tendency towards institutional entrepreneurship. The book finally combines two literature strands: institutionalism and implementation research, showing how street-level workers may be perceived as institutional entrepreneurs.This book will appeal to students, scholars, and researchers of political science, public policy, public administration, and organizational studies, as well as to practitioners and policy-makers interested in a better understanding of institutional entrepreneurs, street work, and the institutional logics perspective. 

The book provides a characteristic of sulfate karst, the features of its distribution and development in the Perm region, based on their own research and generalization of data accumulated in recent years. An updated zoning of the territory is given, partly based on the use of GIS technologies. This book also offers a detailed description of areas with characteristics of geological and hydrogeological conditions for the development of karst and karst phenomena. Besides, it also provides a detailed description of a number of caves, information about specially protected natural areas associated with sulfate karst and new unique objects that need protection. The book describes the influence of karst on economic activity and the ecological situation.The publication is intended for geologists, geographers, ecologists, karst scientists, speleologists, local historians, teachers and students of specialties related to earth sciences, as well as a wide range of karst and cave enthusiasts.

This book explores the political economy of governance in Palestine. It makes a unique contribution to studies of governance and political economy using the Palestinian Authority (PA) as a case study, introducing and developing the concept of 'dual rentierism'. The author uses primary research to chart the evolution of the fiscal sociology of the PA and explore how it has shaped the PA's economic policies and the state-society relationship in the Palestinian Territories. The book adopts a critical political economy approach, making the case that external sources of PA income represent political rents that need to be disaggregated and studied concurrently. It further focuses on the drivers and constraints that have shaped the PA's policy development and state-building associated with its dependence on external revenues. Ultimately, the book elaborates on how the need for fiscal survivability has thwarted the Palestinian quest for statehood. 

This book is a response to the felt need of social work practitioners for professional supervision. Reflecting on the social work profession in the context of contemporary socio-economic and political challenges and wide-ranging organizational and practice settings, the book provides a voice for supervisors to share their experiences. Social workers often deal with difficult, undefined and unique human situations where there are no ready-made solutions or quick fixes. This constant and complex working process can cause stress, burnout and affect their quality of work and judgement if they are not supported appropriately and in a timely way. One such support to them is offering professional supervision to enhance their professional functioning and their quality of service. On the one hand, the narratives of experienced supervisors reveal critical dilemmas, core processes and content, expectations, issues posed, and concepts and theories employed in professional supervision, and on the other, the wisdom and qualities of supervisors. This book analyzes concepts and models employed by supervisors and the complex interaction of their qualities and wisdom that arise from their narratives. It underscores the supervisee's being through integrating the personal and professional self to deliver better quality services to people, agencies, and communities. The book argues that the current trends compel action for well thought through professional supervision for all who need it. Those interested in professional supervision - supervisees, practitioners, and supervisors - will benefit from reading this book. Enlightening Professional Supervision in Social Work: Voices and Virtues of Supervisors is the resource that both supervisors and practitioners need to create safe environments to carefully reflect, develop knowledge, sharpen skills and effectively engage in practice. It will improve services to clients and organizational service provision, and not only benefit both practitioners and supervisors in social work and human services, but also social work educators and students, social policy administrators as well as managers and trainers in the social services sector.  

This book is grounded in an extended analogy between the 19th century story of the Underground Railroad in North America, transporting fugitive slaves to safety in the North, and the 21st century routes and trails of migrant passages to and within Europe. It begins as a kind of historical travelogue tracing the remnants of the 19th-century Underground Railroad in the US and Canada, including its legacies and unfulfilled heritage. It then shifts to the political present by ethnographically sketching a series of different border instances and situations, both external and within the EU space (Ventimiglia, Athens, Paris, Calais, Ceuta and Melilla, Patras, Pozzallo). Focusing on the violent harshening of local border regimes, this book nonetheless suggests a different picture, one conceived as the dynamic effect of both migrants autonomy and of the solidarity provided by local and international groups. Focusing on these specific and contested situations, it is possible to reverse the image of a main borderland into one of a space crisscrossed by many routes and passages. Reading those experiences through the historical lens of the US antebellum Underground Railroad, the book suggests the idea of an analogous "e;Underground Europe"e;.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing.  Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Over the last few decades, various techniques have been developed to alter the properties of plants and animals.  While the targeted transfer of recombinant DNA into crop plants remains a valuable tool to achieve a desirable breeding outcome, integration of transgenes into the host genome has been random, which in part, leads to reduced acceptance of GMOs by the general population in some parts of the world. Likewise, methods of induced mutagenesis, such as TILLING, have the disadvantage that many mutations are induced per plant, which has to be removed again by expensive backcrossing. Advances in genome sequencing have provided more and more information on differences between susceptible and resistant varieties, which can now be directly targeted and modified using CRISPR/Cas9 technology. By selecting specific gRNAs occurrence of off-target modifications are comparatively low. ZFNs and TALENs- based approaches required re-engineering a new set of assembled polypeptides for every new target site for each experiment. The difficulty in cloning and protein engineering prevented these tools from being broadly adopted by the scientific community.  Compared to these technologies, designing the CRISPR toolbox is much simpler and more flexible. CRISPR/Cas9 is versatile, less expensive and highly efficient. It has become the most widely used technology for genome editing in many organisms.Since its inception as a powerful genome-editing tool in late 2012, this breakthrough technology has completely changed how science is performed. The first few chapters in this book introduce the basic concept, design and implementation of CRISPR/Cas9 for different plant systems. They are followed by in-depth discussions on the legal and bio-safety issues accompanying commercialization and patenting of this emerging technology. Lastly, this book covers emerging areas of new tools and potential applications. We believe readers, novice and expert alike, will benefit from this all-in-one resource on genome editing for crop improvement.Chapter 17 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Towards Net Zero in the Building Industry looks at the contributions that the building and construction industry can (and must) make to help achieve net zero carbon emissions. The building industry accounts for close to 40% of global emissions and this book brings together a global group of contributors from 15 countries to examine ways in which the industry can help with overall CO2 reduction. Coverage includes factors such as building design strategy, materials selection, use of local materials with a low carbon imprint, renewable energy use, energy conservation, greenery and appropriate aesthetics, building size and scale, climate suitability, building functionality and comfort, material recycling, and adoption of green policies. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This Atlas focuses on surgical techniques used to treat the entire spectrum of esophageal diseases. Surgical "e;pearls"e; and tips on how to select and perform the correct operation are included and based both on evidence-based data and the experience of the Editors.Step-by-step descriptions of operative and endoscopic procedures in esophageal surgery are provided. Each chapter describes the current indications, perioperative management strategies, and a detailed operative approach with relevant technical considerations.The description of approaches and surgical techniques used in esophageal surgery are outlined in an easily understandable manner for the specific target audience.  This book is written by world-class internationally renowned esophageal surgeons and gastroenterologists

The Socratic method of questioning and refutation (elenchus) predominates the early Platonic dialogues. But things change in the middle dialogues, as Socrates goes beyond merely asking questions and begins to provide answers to his questions. And the method virtually disappears in the late dialogues. The standard explanation of this phenomenon is that the early dialogues were intended to commemorate Socrates and the elenchus, while in the middle and late dialogues Plato went beyond Socrates to present his own mature philosophical thought. In this book, Matthews revises this explanation by uncovering the shortcomings that Plato came to find in the Socratic method and the reasons why Plato lost interest in it.

This book explores how the writers, poets, thinkers, historians, scientists, dilettantes and frauds of the long-nineteenth century addressed the "e;limit cases"e; regarding human existence that medicine continuously uncovered as it stretched the boundaries of knowledge. These cases cast troubling and distorted shadows on the culture, throwing into relief the values, vested interests, and power relations regarding the construction of embodied life and consciousness that underpinned the understanding of what it was to be alive in the long nineteenth century. Ranging over a period from the mid-eighteenth century through to the first decade of the twentieth century-an era that has been called the 'Age of Science'-the essays collected here consider the cultural ripple effects of those previously unimaginable revolutions in science and medicine on humanity's understanding of being.

Compressibility is a property inherent in any material, but it does not always manifest itself. Experience suggests that it affects the medium motion only at velocities comparable to the speed of sound. Why do we study compressibility? It turns out that in order to calculate the aircraft streamlining or the internal flow in its engine, or the shell muzzle velocity, or the dynamic load of a shock wave from an accidental blast on a structural element, and in many other cases it is necessary to know and understand the laws of the Dynamics of Compressible Media (DCM) and be able to apply them in practice. This textbook is designed to help readers achieve this goal and learn the basics of DCM. This field of knowledge is high-tech and always focuses on the future: modern developments of hypersonic aircraft, designing more advanced structural elements for airplanes and helicopters, calculating the car aerodynamics, etc. Paradoxes have always given impetus to the search for new technological devices. Unusual effects in DCM include the flow chocking in supersonic outflow from reservoirs (Sect.2.2); the shock wave formation inside an initially smooth flow (Sect.5.3); the generation of a "e;spallation saucer"e; of armor inside a tank when a shell hits it (Sect.5.5); the dog-leg of a plane discontinuity surface at shockwave reflection from a rigid wall (Sec.8.1). The way to understand these and other effects is through the creation of quantitative models of a moving compressible fluid.

This book explores the foreign and security policies of Germany, France and the UK vis-a-vis China. Despite the progress made by the Lisbon Treaty and notwithstanding the first EU Global Strategy, the European Union does not have a strategy to address the rise of China. Since this strategic deficit does not automatically reflect the level of EU member states, this book argues that the vacuum at EU level provides member states with an opportunity to fill this gap. By assuming that an increase in national policies on China would eventually lead to a comprehensive European strategy for China, the author focuses on the three biggest European countries and looks at the rise of China to understand the development of the EU's Common Foreign and Security Policy vis-a-vis the PRC. While the CFSP depends on the contribution of EU member states, their role in shaping the CFSP towards China has not been researched yet, and this book fills the gap.

This book systematically narrates the fundamentals, methods, and recent advances of evolutionary deep neural architecture search chapter by chapter. This will provide the target readers with sufficient details learning from scratch. In particular, the method parts are devoted to the architecture search of unsupervised and supervised deep neural networks. The people, who would like to use deep neural networks but have no/limited expertise in manually designing the optimal deep architectures, will be the main audience. This may include the researchers who focus on developing novel evolutionary deep architecture search methods for general tasks, the students who would like to study the knowledge related to evolutionary deep neural architecture search and perform related research in the future, and the practitioners from the fields of computer vision, natural language processing, and others where the deep neural networks have been successfully and largely used in their respective fields.