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This book reviews the potential of metallodrugs against different cancer. It summarizes the classification of metal-based anti-cancer drugs, their plausible biochemical and mechanistic pathways, combining drug strategies for hitting multiple therapeutic targets at the intracellular level, and advanced drug delivery strategies. The book covers the metallodrugs for the efficacious treatment of diverse cancerous strains and recent advances in drug delivery strategies that are used for developing these metal-based therapeutics as potent anticancer agents in vitro and in vivo. The book also covers different biophysical and analytical techniques for studying metal-ligand and metal-macromolecular interactions. The book further presents the recent examples of metallomics studies on the different types of cell death induced by metal-based anticancer drugs, especially on the three major forms of programmed cell death (PCD) in mammalian cells: apoptosis, autophagy, and regulated necrosis, alsocalled necroptosis. Lastly, the book explores the modulation of reactive oxygen species (ROS) by metallodrugs.

This book presents peer-reviewed articles from the 8th International Conference on Space Science and Communication (IConSpace 2023), held at Penang in Malaysia. It addresses complications of ground-breaking initiatives and solutions for space science and communications research, telecommunications, and meteorology. With the theme Advanced Space Technology: Accelerating Global Agenda will provide valid information to understand trends, evaluate needs, and create global development policies and programs in the best interest of all. It brings together researchers, engineers, geospatialist, meteorologists, astronomers, and practitioners in order to present the latest applications in space science, telecommunications, meteorology, remote sensing, and related fields.

This book provides the reader with the latest research on vibrational circular dichroism (VCD) spectroscopy including its useful features and applications to many fields. The book starts from an unresolved question in gel chemistry of how component molecules are organized in the flexible fibrils of gels. VCD spectroscopy was successful in giving a clear answer to this mystery. The book also describes a key aspect of this technique lay in the fact that VCD signals were remarkably enhanced when chiral molecules formed a stereoregular molecular array over a few hundred nanometers. VCD spectroscopy was also applied to other topics involving chiral molecules such as the chiral discrimination mechanism in heterogeneous asymmetric catalysis and the build-up of supramolecular chirality in molecular crystals. Furthermore, the book covers the recent instrument developments leading to multi-dimensional VCD measurements with the coordinates of wavenumber, space and time. This progress has opened up new biological and medical applications such as the heterogenous distributions of protein domains in insect wings and the quality control of chiral drugs. The last part of the book presents the possibility of medical diagnosis of Alzheimer¿s disease through multi-dimensional VCD analyses. This book appeals not only to researchers and students who study spectroscopy but also to ones in catalysis, biology and medicine as users of the VCD methods.

This book covers the merits and demerits of advanced composite materials with regard to their applications for earthquake-resistant applications. The chapters in the book are divided into the following main topics: (a) the processing and fabrication of fiber-reinforced polymer composite materials, (b) the mechanical characteristics of materials, (c) the design of strengthening and reinforcing systems for earthquake resistance of the deficient structural system, and (d) design of new earthquake-resistant structures using advanced composite materials. The chapters present experimental tests and numerical modeling of responses of various kinds of structural elements for predicting the load versus deflection response, energy absorption capacity, ductility index, energy ratios, failure modes, and load capacity. It also looks at different kinds of composite systems and their hybrid or functionally graded composites using advanced composite materials, such as carbon fiber-reinforced polymer (CFRP), glass fiber-reinforced polymer (GFRP), aramid fiber-reinforced polymer (AFRP), basalt fiber-reinforced polymer (BFRP), and natural fiber-reinforced polymer (NFRP). The results presented in this book will be of high interest to scientists, researchers, students, and engineers working in the fields of advanced composite materials such as FRPs and other forms of composites for seismic retrofitting and strengthening of deficient structures. This book is helpful for teachers and (undergraduate, Master, and Ph.D.) students to develop a fundamental understanding of the design of earthquake-resistant design of structures (such as buildings, bridges, and industrial structures) using lightweight, durable, and sustainable FRP materials.

Kolmogorov equations are a fundamental bridge between the theory of partial differential equations and that of stochastic differential equations that arise in several research fields.This volume collects a selection of the talks given at the Cortona meeting by experts in both fields, who presented the most recent developments of the theory. Particular emphasis has been given to degenerate partial differential equations, Itô processes, applications to kinetic theory and to finance.

This book aims at bringing out comprehensive information on cropping systems modelling in the world. The major focus of this book is to address the integration of soil, plant and environmental interactions for climate smart agriculture. This book covers aspects of application of Decision Support System for Agrotechnology Transfer (DSSAT) for climate smart agriculture. Step-by-step details of application of modelling approaches used for various cropping systems under changing climate are provided which are being adopted by farmers in the world. The book is enriched with figures or diagrams to show the various mechanisms involved to support the decision making for climate change adaptations. Essential information is given regarding crop models calibration, evaluation and application and every individual chapter is comprised of a specific cropping system. Further contents include integration of climate models and crop models for refining the decisions for sustaining the production of various cropping systems for climate smart agriculture. This book assists the agricultural scientists involved in research regarding climate smart agriculture for improving the standards of agricultural research for ensuring food security under changing climate. This is also equally useful for policy makers being involved in future planning.

This book gathers selected research papers presented at the 5th International Conference on Energy Systems, Drives, and Automation (ESDA 2022). It covers a broad range of topics in the fields of renewable energy, power management, drive systems for electrical machines, and automation. This book also comprehensively discusses related tools and techniques and is a valuable resource for researchers, professionals, and students in electrical and mechanical engineering disciplines.

The book presents latest results pertaining to challenges faced by researchers in space data management. There are large number of highly important applications that currently rely upon data from satellites and space missions, ranging from weather prediction to monitoring of environmental pollution, climate change, marine traffic, agriculture, and urban planning, etc. The quality and quantity of space data poses new and specific challenges to the scientific community, covering the entire life cycle of space data management and with a need for an interdisciplinary approach. The chapters written by experts discusses impacts of these challenges, and report activities that can stimulate new research.

This edited volume elucidates state-of-the-art information and provides new paradigms of soil health-based pathways for sustaining plantation crops and diversified systems. The book covers soil characteristics, soil fertility constraints, issues of soil contamination, the impact of climate change on plantation soils, indicators of soil health and soil health assessment, fertility management for healthy soils, soil amendments, soil biodiversity, and biological functions and micro-biome as well as meta-genomic approach.Plantation crops are perennials, cultivated in tropical and sub-tropical agroecosystems in a contiguous area, and comprise estate crops which include tea, coffee, and rubber and small holders¿ plantation crops such as coconut, areca nut, oil palm, cashew, cocoa, and spices. These are high-value crops with considerable significance in livelihood security, commerce, and trade, and are grown in ecologically vulnerable regions such as coastal belts, hilly areas, andregions with high rainfall and high humidity, which makes maintenance of soil health a major challenge. Sustainable agricultural production depends on the health, quality, and functionality of the soil. The book includes technological options to achieve sustainable production encompassing soil health improvement through multi-strata, multi-species cropping systems, integrated farming systems, conservation agriculture practices, cover cropping and green manuring, crop residue recycling, bio-fertilizer and bio-stimulant technologies and organic farming systems.This book is an essential resource for researchers, plantation professionals, educators, and policymakers. It provides valuable insights and practical solutions for addressing emerging issues in soil health management and is a must-read for students of agriculture, forestry, ecology, microbiology, soil science, and environmental sciences.

This book presents select proceedings of the conference on "High Voltage-Energy Storage Capacitors and Applications (HV-ESCA 2023)" that was jointly organized by Beam Technology Development Group (BTDG) and Electronics & Instrumentation Group (E&IG), BARC at DAE Convention Centre, Anushakti Nagar from 22nd to 24th June 2023. The book includes papers on topics, such as energy storage technologies (capacitor & battery), HV insulation & dielectric material, electromagnetic accelerators (rail and coil gun), electron beam accelerators, generation of fast rising voltage pulses, topologies & control schemes in power modules, pulsed nuclear radiation generators, electromagnetic welding, EMI & EMC, HV transmission lines, insulation material, and plasma generators. Papers included in this book impart better understanding of phenomena and intricacies of high voltage-energy storage capacitors and its applications to practicing engineers and researchers and update the latest information on interdisciplinary trending techniques. The book can be a valuable reference for beginners, researchers, and professionals interested in energy storage, pulsed power, and allied fields.

This book is a collection of academic articles selected from papers published in the Chinese journal Educational Research in 2021¿2022. Educational Research was first published in 1979 and is a national, comprehensive, and theoretical journal of education research. It is sponsored by the Ministry of Education of the People's Republic of China and the China National Academy of Educational Sciences (CNAES). This book presents 20 important educational research articles and covers topics such as educational policies, education technologies, teacher education, and moral education. This book showcases a curated selection of education research outcomes in China and aids readers in developing a comprehensive understanding of China's education reform and development.

This book focuses on the sustainable security practices in the domain of blockchain, quantum, and post-quantum technologies dealing with the real-time applications. The topics discussed in this book include banking applications, protection of digital assets in healthcare, military defense applications, supply chain management, secure messaging, and keyless secure infrastructures.Blockchains and quantum technologies are the emerging technological developments both in academic and industrial domains. The problems related to quantum threat and execution of post-quantum signatures in a blockchain platform have become hot topics in today's scientific community because they have remarkably progressed in recent years and have found a variety of applications.This book is a valuable resource for academicians, researchers, students, and technicians in the field of blockchain and quantum computing.

This book addresses the pressing challenges faced by renewable power system operation (RPSO) due to the increasing penetration of renewable energy and flexible load. These challenges can be divided into two categories. Firstly, the inherent uncertainties associated with renewable energy sources pose significant difficulties in RPSO. Secondly, the presence of various types of flexible load, along with their complex constraint relationships, adds to the operational complexities. Recognizing the growing emphasis on the economic and low-carbon aspects of RPSO, this book focuses on the key issues of flexible load control. It mainly consists of following categories: (1) The control of data centers, a booming flexible load, to enhance RPSO through renewable energy integration and advanced robust multi-objective optimization. (2) The introduction of flexible industrial load control, employing effective demand-supply cooperative responding strategies for RPSO. (3) The exploration of electricvehicle flexible charging load control and centralized electric vehicle charging system control in the context of RPSO. The book also covers the emerging field of flexible integrated load control for renewable energy-based comprehensive energy system operation. Aimed at researchers, engineers, and graduate students in electrical engineering and computer science, this book provides a valuable resource for understanding and implementing flexible load control in the context of RPSO.

This book constitutes the refereed proceedings of the 14th BenchCouncil International Symposium on Benchmarking, Measuring, and Optimizing, Bench 2023, held in Sanya, China, during December 3¿5, 2023. The 11 full papers included in this book were carefully reviewed and selected from 20 submissions. The Bench symposium invites papers that exhibit three defining characteristics: (1) It provides a high-quality, single-track forum for presenting results and discussing ideas that further the knowledge and understanding of the benchmark community; (2) It is a multi-disciplinary conference, attracting researchers and practitioners from different communities, including architecture, systems, algorithms, and applications; (3) The program features both invited and contributed talks.

This edited book is a comprehensive compilation of applications of plant molecular farming in various fields including agriculture, industry and medicine, using different plant/crop systems as bioreactors for the bulk production of products of interest. The book places special emphasis on plant molecular farming being utilized for the bulk production of biologics, industrial enzymes, vaccines, drugs and recombinant pharmaceutical proteins.Plant molecular farming (PMF) is an upcoming promising interdisciplinary subject, and therefore the book contains contributions from experts across the disciplines. The utilization of plant viral vectors to produce biologics, virus-like particles and antimicrobial peptides via PMF have been highlighted. Molecular farming for the bulk production of recombinant pharmaceutical proteins and various types of human and veterinary vaccines in different crops/plants and genetically modified seeds has been included. The process of scaling up to manufacturing capacity, product formation by bioprocessing of plant cell suspension culture, and bioreactor engineering have been incorporated. Lastly, the book provides special coverage on utilizing PMF made products to control neglected tropical diseases and plant-made antigens as immunotherapies for allergic and autoimmune diseases.The book has chapters from leading experts on the subject, making it equally beneficial for researchers, policy planners, industrialists, medical professionals, entrepreneurs, and students of various related disciplines.

This book contains the original, peer-reviewed research papers from the International Symposium on Automatic Control and Emerging Technologies, held in Kenitra, Morrocco, on July 11-13, 2023. The topics covered include but are not limited to: System Identification, Linear/Nonlinear Control Systems, Data-driven Modelling and Control, Process Modelling and Process Control, Fault Diagnosis and Reliable Control, Intelligent Systems, and Machine Learning and Artificial Intelligence.The papers showcased here share the latest findings on topics with potential for academic research and industrial applications, making the book a valuable resource for researchers, engineers, and university students alike.

This volume presents modern trends in the area of symmetries and their applications based on contributions to the Workshop "Lie Theory and Its Applications in Physics" held in Sofia, Bulgaria (on-line) in June 2021.Traditionally, Lie theory is a tool to build mathematical models for physical systems. Recently, the trend is towards geometrization of the mathematical description of physical systems and objects. A geometric approach to a system yields in general some notion of symmetry which is very helpful in understanding its structure. Geometrization and symmetries are meant in their widest sense, i.e., representation theory, algebraic geometry, number theory, infinite-dimensional Lie algebras and groups, superalgebras and supergroups, groups and quantum groups, noncommutative geometry, symmetries of linear and nonlinear partial differential operators, special functions, and others. Furthermore, the necessary tools from functional analysis are included. This is a big interdisciplinary and interrelated field.The topics covered in this Volume are the most modern trends in the field of the Workshop: Representation Theory, Symmetries in String Theories, Symmetries in Gravity Theories, Supergravity, Conformal Field Theory, Integrable Systems, Quantum Computing and Deep Learning, Entanglement, Applications to Quantum Theory, Exceptional quantum algebra for the standard model of particle physics, Gauge Theories and Applications, Structures on Lie Groups and Lie Algebras.This book is suitable for a broad audience of mathematicians, mathematical physicists, and theoretical physicists, including researchers and graduate students interested in Lie Theory.

This book comprises state-of-the-art papers in manufacturing engineering & processes including computer-aided design and manufacturing, environmentally sustainable manufacturing processes, modelling, analysis, and simulation of manufacturing processes, composite materials manufacturing, nanomaterials and nano-manufacturing, semiconductor materials manufacturing, rapid manufacturing technologies, 3D printing and non-traditional manufacturing engineering and processes. In particular, the papers in the book cover latest advances especially in 3D printing and additive manufacturing techniques and processes for sustainable materials including ceramic and polymer-matrix composite where there is paucity of good papers in the literature. The contents of this volume will be useful to researchers and practicing engineers alike.

This book explores the experiences of the ethnic and religious minorities of Iran, such as Jews, Yarsani, Christian, Sabean Mandaean, Bahai, Zoroastrian, Baluch, Kurd, and others and provides a historical overview of their position in society before and after the 1979 Islamic revolution and highlights their contribution to the country's history, diversity, and development. It also focuses on the historical, sociopolitical, and economic factors that affected the minorities' development during the last century. Author Behnaz Hosseini has shaped this book with authentic material and has assembled the experiences and opinions of academics of diverse backgrounds who approach the minorities¿ issues in Iran in a constructive and ingenious way: from debating their efforts to preserve their identity and cultural heritage and ensure their survival to discussing their relations with the majority and other minorities, the role of religion in everyday life, and their contribution to the rich cultural history of Iran.

This book gives a complete overview of current developments in the nano drug delivery technology in the management of neurological disorders and brain diseases. The book is divided into three main sub-sections: A) Fundamental study on nanomaterials, nanocarriers, and nanoformulation-based drug delivery in neurological diseases management, B) Nano drug delivery therapy - a novel approach towards common neurological disorders and C) Novel nano delivery strategies in targeted neurological diseases management. This collective work presents diverse nano-based drug delivery technologies that are high-throughput, reliable, pioneering, and applicable to researchers of different countries despite their socio-economic conditions. It hopefully encourages researchers, innovators and policymaker to adapt nanomaterial-based drug delivery vehicles technologies using diverse nano-based formulation techniques as targeted therapy for treating and managing neurological disorders.

This textbook is designed for students and researchers who are interested in materials and catalysts informatics with little to no prior experience in data science or programming languages. Starting with a comprehensive overview of the concept and historical context of materials and catalysts informatics, it serves as a guide for establishing a robust materials informatics environment. This essential resource is designed to teach vital skills and techniques required for conducting informatics-driven research, including the intersection of hardware, software, programming, machine learning within the field of data science and informatics. Readers will explore fundamental programming techniques, with a specific focus on Python, a versatile and widely-used language in the field. The textbook explores various machine learning techniques, equipping learners with the knowledge to harness the power of data science effectively. The textbook provides Python code examples, demonstrating materials informatics applications, and offers a deeper understanding through real-world case studies using materials and catalysts data. This practical exposure ensures readers are fully prepared to embark on their informatics-driven research endeavors upon completing the textbook. Instructors will also find immense value in this resource, as it consolidates the skills and information required for materials informatics into one comprehensive repository. This streamlines the course development process, significantly reducing the time spent on creating course material. Instructors can leverage this solid foundation to craft engaging and informative lecture content, making the teaching process more efficient and effective.

This book contains select proceedings of EPREC-2021 with a focus on power electronics and drives. The book includes original research and case studies that present recent developments in power electronics focusing on power inverters and converters. The book also consists of research work on electrical drives, regulated power supplies, operation of FACTS & HVDC, etc. The book will be a valuable reference guide for beginners, researchers, and professionals interested in the advancements of power electronics and drives.

This book includes focal and vital cases tried by presiding justices, guiding cases from the Supreme People¿s Court, and cases discussed at the Joint Meetings of Presiding Judges from various tribunals. This book is divided into three sections, including Cases by Justices, Guiding Cases, and Typical Cases, which will introduce readers to Chinese legal processes, legal methodology, and ideology in an intuitive, clear, and accurate manner. This book presents cases selected by the trial departments of the Supreme People¿s Court of China from their concluded cases. In order to give full weight to the legal value and social function of cases from the Supreme People¿s Court, and to achieve the goal of ¿serving the trial practices, serving economic and social development, serving legal education and legal scholarship, serving legal exchanges among Chinese and foreign legal communities, and serving the rule of law in Chinä, the China Applied Jurisprudence Institute, with the approval of the Supreme People¿s Court, opts to publish Selected Cases from the Supreme People¿s Court of the People¿s Republic of China in both Chinese and English, for domestic and overseas distribution.

This book uses Pierre Bourdieüs cultural capital model as a theoretical framework for exploring how students in Beijing and Hong Kong perceive parental influences¿their parents¿ cultural capital and support¿on their participation in musical activities. By studying students¿ perceptions of their parents¿ cultural capital and support for their musical activities, this book revisits the applicability of Bourdieüs cultural capital model in the contemporary Chinese context and reveals how inequality in terms of parental cultural capital governs parents¿ support and influences the intergenerational transmission of cultural capital, which in turn contributes to inequality in terms of students¿ cultural capital.

This book explores the current impasse that global regulators face in the digital sphere. Computer technology has advanced human civilization tenfold, but the freedom to interact with others in cyberspace has made individuals, discrete communities, organizations and governments more vulnerable to abuse.  In consequence, political decision-makers are seriously considering granting limited legal immunity to victims who decide to `hack- back.¿ Many victims frustrated by the slow pace of law enforcement in cyberspace have chosen to `take the law into their own hands,¿ retaliating against those who have stolen valuable data and damaged network operations. Political deliberations about limited immunity for hackbacks usually ignore global justice and moral justifications for `active defense¿ policies. Typically, cyber security policies balance deterrence against two different understandings of morality and the `good life¿ : fairness or welfare.  This book proposes a third moral rationale for cyber security policies : capability theory, developed principally by Amartya Sen and Martha Nussbaum. Properly formulated, a capability-based defense of retaliatory hackbacks can minimize attribution and cyber-escalation risks, deter bad behavior by casual computer users, disingenuous security experts, big tech companies, criminals and rogue governments, and satisfy calls for more retributive and distributive justice in the `open world¿. This book will appeal to legal theorists, political philosophers, social activists, investors, international relations scholars and businesspeople in the tech community.A. Jean Thomas is a lawyer and former programmer who has taught at two law schools. She has a BA from Swarthmore College, JD from University of Connecticut Law School and LL.M and S.J.D. from Harvard Law School.