Bøker utgitt av Springer Nature Switzerland AG

This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ¿Computational sequence design for DNA nanostructures¿ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.

This textbook presents, in a mathematically precise manner, a unified introduction to deterministic control theory. With the exception of a few more advanced concepts required for the final part of the book, the presentation requires only a knowledge of basic facts from linear algebra, differential equations, and calculus.In addition to classical concepts and ideas, the author covers the stabilization of nonlinear systems using topological methods, realization theory for nonlinear systems, impulsive control and positive systems, the control of rigid bodies, the stabilization of infinite dimensional systems, and the solution of minimum energy problems.This second edition includes new chapters that introduce a variety of topics, such as controllability with vanishing energy, boundary control systems, and delayed systems. With additional proofs, theorems, results, and a substantially larger index, this new edition will be an invaluable resource for students and researchers of control theory.Mathematical Control Theory: An Introduction will be ideal for a beginning graduate course in mathematical control theory, or for self-study by professionals needing a complete picture of the mathematical theory that underlies the applications of control theory.From reviews of the first edition:At last! We did need an introductory textbook on control which can be read, understood, and enjoyed by anyone. Gian-Carlo Rota, The Bulletin of Mathematics BooksIt covers a remarkable number of topics...The exposition is excellent, and the book is a joy to read. A novel one-semester course covering both linear and nonlinear systems could be given...The book is an excellent one for introducing a mathematician to control theory. Bulletin of the AMSIndeed, for mathematicians who look for the basic ideas or a general picture about the main branches of control theory, I believe this book can provide anexcellent bridge to this area. IEEE Control Systems Magazine

This volume presents a broad discussion of computational methods and theories on various classical and modern research problems from pure and applied mathematics. Readers conducting research in mathematics, engineering, physics, and economics will benefit from the diversity of topics covered. Contributions from an international community treat the following subjects: calculus of variations, optimization theory, operations research, game theory, differential equations, functional analysis, operator theory, approximation theory, numerical analysis, asymptotic analysis, and engineering.Specific topics include algorithms for difference of monotone operators, variational inequalities in semi-inner product spaces, function variation principles and normed minimizers, equilibria of parametrized N-player nonlinear games, multi-symplectic numerical schemes for differential equations, time-delay multi-agent systems, computational methods in non-linear design of experiments, unsupervisedstochastic learning, asymptotic statistical results, global-local transformation, scattering relations of elastic waves, generalized Ostrowski and trapezoid type rules, numerical approximation, Szász Durrmeyer operators and approximation, integral inequalities, behaviour of the solutions of functional equations, functional inequalities in complex Banach spaces, functional contractions in metric spaces.

This book aims to understand how the wellbeing benefits of urban green space (UGS) are analysed and valued and why they are interpreted and translated into action or inaction, into ¿success¿ and/or ¿failure¿. The provision, care and use of natural landscapes in urban settings (e.g. parks, woodland, nature reserves, riverbanks) are under-researched in academia and under-resourced in practice. Our growing knowledge of the benefits of natural urban spaces for wellbeing contrasts with asset management approaches in practice that view public green spaces as liabilities. Why is there a mismatch between what we know about urban green space and what we do in practice? What makes some UGS more ¿successful¿ than others? And who decides on this measure of ¿success¿ and how is this constituted? This book sets out to answer these and related questions by exploring a range of approaches to designing, planning and managing different natural landscapes in urban settings.

This revised and significantly expanded edition contains a rigorous examination of key concepts, new chapters and discussions within existing chapters, and added reference materials in the appendix, while retaining its classroom-tested approach to helping readers navigate through the deep ideas, vast collection of the fundamental methods of structural analysis. The authors show how to undertake the numerous analytical methods used in structural analysis by focusing on the principal concepts, detailed procedures and results, as well as taking into account the advantages and disadvantages of each method and sphere of their effective application. The end result is a guide to mastering the many intricacies of the range of methods of structural analysis. The book differentiates itself by focusing on extended analysis of beams, plane and spatial trusses, frames, arches, cables and combined structures; extensive application of influence lines for analysis of structures; simple and effective procedures for computation of deflections; introduction to plastic analysis, stability, and free and forced vibration analysis, as well as some special topics. Ten years ago, Professor Igor A. Karnovsky and Olga Lebed crafted a must-read book. Now fully updated, expanded, and titled Advanced Methods of Structural Analysis (Strength, Stability, Vibration), the book is ideal for instructors, civil and structural engineers, as well as researches and graduate and post graduate students with an interest in perfecting structural analysis.

This book discusses the potential of a systemic and multidisciplinary design approach to improve urban quality, health, livability, and inclusiveness for people living in informal settlements. In most instances, attempts to address informal settlements lack an adequate assessment of their impact on the wider built environment and implementation of the UN¿s Sustainable Development Goals. The Integrated Modification Methodology (IMM), introduced here, offers a systematic, multidisciplinary design tool encompassing several of the aspects that define the environmental performance of urban systems. The book also demonstrates the application of the methodology to an informal settlement, proving its potential to guide systemicurban transformations, also in urban areas lacking formal planning. The case study investigated is in the Rocinha favela in Rio de Janeiro, which ischaracterized by poor water quality, lack of drainage and sanitation systems, and very few green spaces. Based on a rigorous methodology, the process described here can also be applied in similar contexts around the world.

This comprehensive guide to short implants will take the reader through their research and development, explain the clinical indications, evaluate the outcomes achieved with various implants, and explore restorative and laboratory considerations. Short implants have steadily gained greater market share in the last decade as practitioners sought alternatives to traditional length implants in order to avoid grafting procedures. Current manufacturers offer a variety of implant lengths and widths, allowing surgeons and restorative dentists the ability to select the best implant for each clinical circumstance. Cutting edge information is provided on the research and clinical results achieved utilizing a range of implants, specifically those developed by Nobel Biocare, Straumann, Jack Hahn, and Bicon. Readers will also find an extensive description of the role of ultra-short implants involving reconstruction in both cleft patients and cancer patients who have lost portions oftheir mandible and/or maxilla. This book is a must-have for those interested in learning how the use of short and ultra-short implants offers both surgeons and restorative dentists an opportunity to stand out from those that use only the traditional length implants.

This comprehensive guide to short implants will take the reader through their research and development, explain the clinical indications, evaluate the outcomes achieved with various implants, and explore restorative and laboratory considerations. Short implants have steadily gained greater market share in the last decade as practitioners sought alternatives to traditional length implants in order to avoid grafting procedures. Current manufacturers offer a variety of implant lengths and widths, allowing surgeons and restorative dentists the ability to select the best implant for each clinical circumstance. Cutting edge information is provided on the research and clinical results achieved utilizing a range of implants, specifically those developed by Nobel Biocare, Straumann, Jack Hahn, and Bicon. Readers will also find an extensive description of the role of ultra-short implants involving reconstruction in both cleft patients and cancer patients who have lost portions oftheir mandible and/or maxilla. This book is a must-have for those interested in learning how the use of short and ultra-short implants offers both surgeons and restorative dentists an opportunity to stand out from those that use only the traditional length implants.

This book provides a comprehensive resource on various aspects of the parasite Trypanosoma cruzi and the neglected tropical disease Chagas disease (American trypanosomiasis), the disorder resulting from infection with the parasite. Topics include the biological description and taxonomy of the parasite, epidemiology and transmission routes, laboratory techniques in use when working with the parasite, as well as diagnostic measures and treatment of Chagas disease. Furthermore, a chapter with life stories of people in contact with the disease in endemic as well as non-endemic countries is included. The book is therefore a valuable source for individuals engaged in basic research as well as patient care and health management related to American trypanosomiasis.

This book explores how population mobility varies among the countries of Asia. While much attention has been given to international migration, movement within countries is numerically much more significant. Coupling innovative methods developed in the global IMAGE project with the contextual knowledge of experts on 15 Asian countries, the book measures and explains how people across Asia differ in the probability of changing residence, the ages at which they move, and the impact of these migrations on the distribution of human settlement within each country. It demonstrates how stage of economic development, coupled with historical events, local contingencies, cultural norms, political frameworks, and the physical environment shape human migration. By using rigorous statistics in a robust comparative framework, this book provides a clear understanding of contemporary migration in Asia for students and academics, and a valuable resource for policy-makers and planners in Asia andbeyond.