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The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties

Gathering the proceedings of the XXVII Brazilian Congress on Biomedical Engineering, CBEB 2020, held on October 26-30, 2020, in Vitoria, Brazil, and promoted by the Brazilian Society of Biomedical Engineering - SBEB, this book gives emphasis to research and developments carried out by Brazilian scientists, institutions and professionals.

This volume provides an understanding of how systems of child protection evolve in disparate cultural, social and economic contexts. Using the former Soviet Union as a starting point, it examines how 13 countries have developed, defined and evolved their system of protecting children and providing services to families over the last 25 years since independence. The volume runs an uniform approach in each country and then traces the development of unique systems, contributing to the international understanding of child protection and welfare.  This volume is a fascinating study for social scientists, social workers, policy makers with particular interest to those focusing on children, youth, and family issues alike as each chapter offers a clear and compelling view of the central changes, competing claims and guiding assumptions that have formed each countries individual approach to child protection and family services.  

This book gathers outstanding papers presented at the European Conference on Numerical Mathematics and Advanced Applications (ENUMATH 2019). The conference was organized by Delft University of Technology and was held in Egmond aan Zee, the Netherlands, from September 30 to October 4, 2019. Leading experts in the field presented the latest results and ideas regarding the design, implementation and analysis of numerical algorithms, as well as their applications to relevant societal problems.ENUMATH is a series of conferences held every two years to provide a forum for discussing basic aspects and new trends in numerical mathematics and scientific and industrial applications, all examined at the highest level of international expertise. The first ENUMATH was held in Paris in 1995, with successive installments at various sites across Europe, including Heidelberg (1997), Jyvaskyla (1999), lschia Porto (2001), Prague (2003), Santiago de Compostela (2005), Graz (2007), Uppsala (2009), Leicester (2011), Lausanne (2013), Ankara (2015) and Bergen (2017).

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract.

The Arabian Seas Marine Region encompasses marine areas from Djibouti to Pakistan, including the northern part of Somalia, the Red Sea, the Arabian/Persian Gulf, and parts of the Arabian Sea. Human pressures on the coastal and marine environments are evident throughout the region, and have resulted in harmful environmental effects.

This book includes over three hundred and seventy-five short papers presented during the second EMCEI, which was held in Sousse, Tunisia in October 2019. After the success of the first EMCEI in 2017, the second installment tackled emerging environmental issues together with new challenges, e.g. by focusing on innovative approaches that contribute to achieving a sustainable environment in the Mediterranean and surrounding regions and by highlighting to decision makers from related sectors the environmental considerations that should be integrated into their respective activities. Presenting a wide range of environmental topics and new findings relevant to a variety of problems in these regions, this volume will appeal to anyone working in the subject area and particularly to students interested in learning more about new advances in environmental research initiatives in view of the worsening environmental degradation of the Mediterranean and surrounding regions, which has made environmental and resource protection into an increasingly important issue hampering sustainable development and social welfare.

The Commentary on the Treaty on the Functioning of the European Union (four volumes) is a major European project that aims to contribute to the development of ever closer conceptual and dogmatic standpoints with regard to the creation of "Europeanised research on Union law".

This handbook focuses on the education systems in the three Americas, North, Central and South America, and includes a chapter on most countries in the region.

This book proposes a novel approach to the design of accessible and inclusive sailing yachts, inspired by the principles of ΓÇ£Design for All.ΓÇ¥  The goal is to allow anyone, including users with disabilities and individuals belonging to the weaker segments, to sail without barriers. Starting from an analysis of existing pleasure boats, the author identifies a series of factors limiting the accessibility or usability of external and internal spaces. In turn, he discusses the most suitable solutions to each. By proposing an extensive set of design solutions applicable to the confined spaces on yachts, and which comply with the relevant anthropometric and dimensional rules, the book offers a timely snapshot of the potential benefits and applicability of an inclusive approach to yacht design, setting a new reference standard for inclusive and accessible nautical design.  

This book is devoted to the last part of Aristotle¿s collection of short treatises known today as the Parva Naturalia, i.e. the treatise On Youth and Old Age, on Life and Death, on Respiration. In the three main sections of the book, the author offers a translation, a commentary and a thorough analysis of this work. The author argues in favour of the unity of the work and contextualises its ideas within Aristotle¿s corpus and the medical tradition of his time. After an Introduction to the nature of the work and its significance for the history of natural philosophy and science, a new English translation follows, along with a detailed commentary of Chapters 1-6, which combines philosophical discussion with philological observations. The book includes four interpretive essays, which tackle problems related to the whole treatise on a more philosophical basis, including questions about the structure and unity ofthe work, the organisation of the material, Aristotle¿s methodological principles, his aims and target audience as well as the relevance of his selected themes to the thematic agenda of some Hippocratic writings. This book is of interest to students and researchers in Aristotle¿s psychophysiology, and his views about the embodied mind, as well as to anyone concerned with the history of natural philosophy and science more generally.

Criminology has until recently neglected the nature and levels of crime outside the urban realm. This is not a surprise as crime tends to concentrate in urban areas and the police directs resources where the problems are. Yet, there are many reasons why scholars, decision-makers and society as a whole should care about crime and safety in rural areas. First, low crime rates in rural areas are mistakenly taken as a sign that crime is not a problem for those living there (Yarwood, 2001). Second, we argue that crime is not simply an urban phenomenon; it embodies the very same characteristics of the environment it is embedded, in certain cases, crime commission is only possible at those situational rural contexts (e.g., Stassen and Ceccato, 2020). Finally, crime in rural areas are in constant transformation given local and global influences, imposing challenges for policing and not least, for the long term sustainability of rural areas.This book highlights 20 reasons why crime and safety in rural areas is a topic of relevance. We attempt to untangle currently simplistic views of the rural by discussing a number of facets of the countryside as both safe and criminogenic, and more importantly, a hybrid place worth to be examined in its own right. Then, the book critically reviews a rich body of English-language literature in rural criminology that extends over more than five decades¿a scholarship that has engaged researchers and practitioners in all continents. The books finishes with a discussion of the emergent research questions of the field, and offers suggestions for further reading. This is an open access book.

This open access book applies insights from the network perspective in health research to explain the reproduction of health inequalities. It discusses the extant literature in this field that strongly correlates differences in social status with health behaviours and outcomes, and add to this literature by providing a coherent theoretical explanation for the causes of these health inequalities. It also shows that much research is needed on the precise factors and the social and socio-psychological mechanisms that are at play in creating and cementing social inequalities in health behaviours. While social support and social relations have received considerable attention within social and behavioural science research on health inequalities, this book considers the whole network of interpersonal relations, structures and influence mechanisms. This is the perspective of the social network analytical approach which has recently gained much attention in health research. The chapters of thisbook cover state-of-the-art research, open research questions, and perspectives for future research. The book provides network analyses on health inequalities from the perspective of sociology, psychology, and public health and is of interest to a wide range of scholars, students and practitioners trying to understand how health inequalities are reproduced across generations.

This open access book applies insights from the network perspective in health research to explain the reproduction of health inequalities. It discusses the extant literature in this field that strongly correlates differences in social status with health behaviours and outcomes, and add to this literature by providing a coherent theoretical explanation for the causes of these health inequalities. It also shows that much research is needed on the precise factors and the social and socio-psychological mechanisms that are at play in creating and cementing social inequalities in health behaviours. While social support and social relations have received considerable attention within social and behavioural science research on health inequalities, this book considers the whole network of interpersonal relations, structures and influence mechanisms. This is the perspective of the social network analytical approach which has recently gained much attention in health research. The chapters of thisbook cover state-of-the-art research, open research questions, and perspectives for future research. The book provides network analyses on health inequalities from the perspective of sociology, psychology, and public health and is of interest to a wide range of scholars, students and practitioners trying to understand how health inequalities are reproduced across generations.

This book deals with some aspects of the future shape of the socio-economic order which would be founded on sustainability principles and the role of law therein, instead of on the prevailing capitalist economic order. The volume elaborates in particular on how innovation, a crucial aspect of free-market capitalism and its laws which constitute the current socio-economic order, could result in a more sustainable economy which, in turn, could lead to a more sustainable society. Moreover, the book analyses current developments in financial and economic law and evaluates their perks, risks and sustainability levels.The book contains no less than 11 chapters in which a variety of experts share their state-of-the-art insights regarding specific domains of socio-economic life. As such, the book deals with topics that are at present fully under debate in societies, such as student credit and the dangers it entails, crypto­currencies and how the law tries to regulate this basically privatelaw instrument, groups of companies under Belgian (company) law, a proposal for improving the international monetary system, and seeds and intellectual property rights, besides various other similar themes.The book forms the latest volume of the book series Economic and Financial Law & Policy ¿ Shifting Insights & Values, and fully complies with the series¿ goal of critically exa­mining the legal methods and mechanisms that shape the global free markets and proposing alternatives to them. The book will hereby prove a valuable instru­ment for all researchers investigating these matters, besides policymakers and their ad­visers as well as all lawyers active in the field of economic law who look for a new per­spective on the subject matters dealt with.

This volume celebrates the life and career of Gordon Rausser, pioneer and leader in natural resource economics, while critically overviewing the emerging literature in the field. As the chair of the Agriculture and Resource Economics department at UC Berkeley, Rausser led the transformation of the department from a traditional agricultural economics department to a diverse resource economics department addressing issues of agriculture, food, natural resources, environmental economics, energy, and development. This book builds on this theme, showcasing not only the scope of Rausser's work but also key developments in the field.The volume is organized into two parts. The first part speaks about the lessons of Gordon Rausser's career, in particular, his role as a leader in different spheres, his capacity to integrate teaching and entrepreneurship, and his impact on the world food system. The second part will address some of thesignificant developments in the field he contributed to and how it relates to his work. The chapters include contributions from modern leaders in the economics field and cover diverse topics from many subfields including public policy, public finance, law, econometrics, macroeconomics, and water resources.Providing an excellent reference, as well as a celebration of a pivotal figure in the field, this volume will be useful for practitioners and scholars in agricultural and resource economics, especially the many individuals familiar with Gordon Rausser and his career.