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This 2nd edition of the Handbook "Regulatory Toxicology" was written and updated by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It includes a number of new chapters that cover recent developments, such as regulation of nanoparticles, illicit designer drugs or tattoos.The Handbook deals comprehensively with the safety-ensuring methods and concepts employed for acute and chronic toxicity by regulatory agencies, industry and academics.

This book highlights progress towards the capture, storage, and utilization of energy through the development of advanced materials and systems based on abundant elements, materials, and commodities. Energy is critical to human sustainability and a global-scale deployment of renewable energy systems will be required. Hence, the chapters integrate the fundamental aspects that enable the technical advancements in detail, along with an emphasis on the need for highly sustainable materials to enable real impact for humankind: To determine innovation of energy capture and storage through characterizations of materials in areas of electrical generation and electrical storage systems; To demonstrate better performance, economic and environmental advantages than the current state of the art; To define new chemistries and materials for innovations in energy density design through lower operational temperatures, improve safety, expanding operational voltage, battery durability lifetimes, and reduce system costs. Advances critical technical and commercial objectives for novel high energy density materials;Evaluates operational material models for optimizing energy capture that are integrated by configurations as a system; Illustrates utilization of material life cycle assessment for high energy outputs generators for sustainable materials.

This edited book explicitly deals with the energy humanities, summarising existing knowledge in the area and outlining possible future directions for the nascent field. Assuming a variety of disciplinary stances and using a plethora of methodologies to address a number of pressing energy-related issues, the individual contributions showcase the crucial importance of including the humanities and social sciences into the current discussion on energy. Furthermore, they illustrate one of the central claims of the energy humanities, namely, that energy permeates all aspects of our contemporary modes of existence, and is inextricably linked with historical, political, social, ideological, and cultural issues, relationships, and practices.Through numerous case studies, Energy Humanities and Energy Transition looks to the past, present, and future in search of examples of best practices and possible models for pathways to a successful energy transition and life ¿after oil¿. While much of existing research on energy humanities has been criticised for its excessive focus on oil, this book considers a wide range of energy resources, including nuclear energy, renewables, and natural gas. Furthermore, it brings to the forefront under-researched topics such as the colonial legacy inscribed in energy infrastructure and the energy history of the humanities. The contributions in this volume explore not only how the perspectives and expertise of the humanities and social sciences can alter the discourse on energy transition, and our way of thinking about possible solutions and future scenarios, but also how their new focus on energy affects the disciplines themselves.Energy Humanities and Energy Transition presents a variety of theories, methods, topics, and disciplinary angles, meaning it will be of interest to a wide audience, from practitioners and policy makers, to students and researchers working across the humanities and social sciences. The thematically oriented structure, distinct focus of each individual chapter, and the comprehensive introduction and conclusion that contextualize the contributions within the wider framework of energy transition, make this edited book accessible to readers from many different fields and suitable for various university programs.

This self-contained book focuses on the safety assessment of existing structures subjected to multi-hazard scenarios through advanced numerical methods. Whereas the focus is on concrete dams and nuclear containment structures, the presented methodologies can also be applied to other large-scale ones.The authors explains how aging and shaking ultimately lead to cracking, and how these complexities are compounded by their random nature. Nonlinear (static and transient) finite element analysis is hence integrated with both earthquake engineering and probabilistic methods to ultimately derive capacity or fragility curves through a rigorous safety assessment.Expanding its focus beyond design aspects or the state of the practice (i.e., codes), this book is composed of seven sections:Fundamentals: theoretical coverage of solid mechnics, plasticity, fracture mechanics, creep, seismology, dynamic analysis, probability and statisticsDamage: that can affect concrete structures, such as cracking of concrete, AAR, chloride ingress, and rebar corrosion,Finite Element: formulation for both linear and nonlinear analysis including stress, heat and fracture mechanics,Engineering Models: for soil/fluid-structure interaction, uncertainty quantification, probablilistic and random finite element analysis, machine learning, performance based earthquake engineering, ground motion intensity measures, seismic hazard analysis, capacity/fragility functions and damage indeces,Applications to dams through potential failure mode analyses, risk-informed decision making, deterministic and probabilistic examples,Applications to nuclear structures through modeling issues, aging management programs, critical review of some analyses,Other applications and case studies: massive RC structures and bridges, detailed assessment of a nuclear containment structure evaluation for license renewal. This book should inspire students, professionals and most importantly regulators to rigorously apply the most up to date scientific methods in the safety assessment of large concrete structures.

Highlighting the latest advances in nonparametric and semiparametric statistics, this book gathers selected peer-reviewed contributions presented at the 4th Conference of the International Society for Nonparametric Statistics (ISNPS), held in Salerno, Italy, on June 11-15, 2018. It covers theory, methodology, applications and computational aspects, addressing topics such as nonparametric curve estimation, regression smoothing, models for time series and more generally dependent data, varying coefficient models, symmetry testing, robust estimation, and rank-based methods for factorial design. It also discusses nonparametric and permutation solutions for several different types of data, including ordinal data, spatial data, survival data and the joint modeling of both longitudinal and time-to-event data, permutation and resampling techniques, and practical applications of nonparametric statistics.The International Society for Nonparametric Statistics is a unique global organization, and its international conferences are intended to foster the exchange of ideas and the latest advances and trends among researchers from around the world and to develop and disseminate nonparametric statistics knowledge. The ISNPS 2018 conference in Salerno was organized with the support of the American Statistical Association, the Institute of Mathematical Statistics, the Bernoulli Society for Mathematical Statistics and Probability, the Journal of Nonparametric Statistics and the University of Salerno.

This book includes 16 selected contributions presented at the 23rd Evolutionary Biology Meeting, which took place in Marseille in September 2019. The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g. for medical research. The aim of these meetings is to promote the exchange of ideas to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.

This richly illustrated book is a wide-ranging guide to modern diagnostics and treatment planning in orthodontics, which are mandatory prior to the initiation of any type of comprehensive treatment. The importance of three-dimensional (3D) imaging techniques has been increasingly recognized owing to the shortcomings of conventional two-dimensional imaging in some patients, such as those requiring complex adult treatment and those with temporomandibular joint dysfunctions or sleep disturbances. In the first part of this book, readers will find clear description and illustration of the diagnostic role of the latest 3D imaging techniques, including cone beam computed tomography, intra-oral scanning, and magnetic resonance imaging. The second part explains in detail the application of 3D techniques in treatment planning for orthodontic and orthognathic surgery. Guidance is also provided on the use of image fusion software for the purposes of accurate diagnosis and precise design of themost appropriate biomechanical approach in patients with malocclusions.

This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.

The use of non-standard technologies such as superconductivity, cryogenics and radiofrequency pose challenges for the safe operation of accelerator facilities that cannot be addressed using only best practice from occupational safety in conventional industry. This book introduces readers to different occupational safety issues at accelerator facilities and is directed to managers, scientists, technical personnel and students working at current or future accelerator facilities. While the focus is on occupational safety ¿ how to protect the people working at these facilities ¿ the book also touches on ¿machine safety¿ ¿ how to prevent accelerators from doing structural damage to themselves. This open access book offers a first introduction to safety at accelerator facilities. Presenting an overview of the safety-related aspects of the specific technologies employed in particle accelerators, it highlights the potential hazards at such facilities and current prevention and protection measures. It closes with a review of safety management and organization at accelerator facilities.

This book is reflective of a science-based vision of the future development paradigm of economic and social systems. It deals with the digitization as the technological basis for the future development of economic and social systems and presents a review of groundbreaking technologies and prospects for their application. The specific character of the industry and prospects for the application of digital technologies in business are analyzed. A rationale is provided for future prospects for the sustainable development of economic and social systems in a digital economy. The authors determine the process of the formation and development of the information-oriented society, social and educational aspects of the digitization, as well as the institutional framework of the digital future of social and economic systems. The book combines the best works following the results of the 12th International Research-to-Practice Conference ¿Artificial Intelligence: Anthropogenic Nature vs. Social Origin¿ that was held by the Institute of Scientific Communications (ISC) in cooperation with the Siberian Federal University and the Krasnoyarsk Regional Fund of support of scientific and scientific¿technical activities on 5¿7 December 2019, in Krasnoyarsk, Russia, as well as following the results of the 3rd International Research-to-Practice Conference ¿Economic and Social Systems: Paradigms for the Future¿ that was held by the ISC in cooperation with the Pyatigorsk State University on 5¿6 February 2020. The target audience of the book consists of representatives of the academic community concerned with the future prospects for the development of economic and social systems, as well as economic agents engaged in the digitization of business processes, and representatives of public agencies regulating the development of business systems for their progressivity, sustainability and competitiveness.

This open access book presents the major outcomes of the fourth edition of the Future of Higher Education ¿ Bologna Process Researchers Conference (FOHE-BPRC 4) which was held in January 2020 and which has already established itself as a landmark in the European higher education environment. The conference is part of the official calendar of the European Higher Education Area (EHEA) for events that promote and sustain the development of EHEA. The conference provides a unique forum for dialogue between researchers, experts and policy makers in the field of higher education, all of which is documented in this proceedings volume. The book focuses on the following five sub-themes: - Furthering the Internationalization of Higher Education: Particular - Challenges in the EHEA - Access and Success for Every Learner in Higher Education - Advancing Learning and Teaching in the EHEA: Innovation and Links With Research - The Future of the EHEA - Principles, Challenges and Ways Forward - Bologna Process in the Global Higher Education Arena. Going Digital? While acknowledging the efforts and achievements so far at EHEA level, the Paris Ministerial Communiqué highlights the need to intensify crossdisciplinary and cross-border cooperation. One of the ways to achieve this objective is to develop more efficient peer-learning activities, involving policymakers and other stakeholders from as many member states as possible for which this book provides a platform. It acknowledges the importance of a continued dialogue between researchers and decisionmakers and benefits from the experience already acquired, this way enabling the higher education community to bring its input into the 2020. European Higher Education Area (EHEA) priorities for 2020 onwards. European Higher Education Area: Challenges for a New Decade marks 21 years of Bologna Process and 10 years of EHEAand brings together an unique collection of contributions that not only reflect on all that has been achieved in these years, but more importantly, shape directions for the future. This book is published under an open access CC BY license.