Bøker utgitt av Springer Verlag, Singapore

This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances.Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecularmotors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.

This book features a collection of extended papers based on presentations given at the SimHydro 2019 conference, held in Sophia Antipolis in June 2019 with the support of French Hydrotechnic Society (SHF), focusing on ¿Which models for extreme situations and crisis management?¿ Hydraulics and related disciplines are frequently applied in extreme situations that need to be understood accurately before implementing actions and defining appropriate mitigation measures. However, in such situations currently used models may be partly irrelevant due to factors like the new physical phenomena involved, the scale of the processes, and the hypothesis included in the different numerical tools. The availability of computational resources and new capacities like GPU offers modellers the opportunity to explore various approaches to provide information for decision-makers. At the same time, the topic of crisis management has sparked interest from stakeholders who need to share a commonunderstanding of a situation. Hydroinfomatics tools can provide essential information in crises; however, the design and integration of models in decision-support systems require further development and the engagement of various communities, such as first responders. In this context, methodologies, guidelines and standards are more and more in demand in order to ensure that the systems developed are efficient and sustainable.Exploring both the limitations and performance of current models, this book presents the latest developments based on new numerical schemes, high-performance computing, multiphysics and multiscale methods, as well as better integration of field-scale model data. As such, it will appeal to practitioners, stakeholders, researchers and engineers active in this field.

This book systematically provides a prospective integrated approach for complexity social science in its view of statistical physics and mathematics, with an impressive collection of the knowledge and expertise of leading researchers from all over the world. The book mainly covers both finitary methods of statistical equilibrium and data-driven analysis by econophysics.The late Professor Masanao Aoki of UCLA, who passed away at the end of July 2018, in his later years dedicated himself to the reconstruction of macroeconomics mainly in terms of statistical physics. Professor Aoki, who was already an IEEE fellow, was also named an Econometric Society Fellow in 1979. Until the early 1990s, however, his contributions were focused on the new developments of a novel algorithm for the time series model and their applications to economic data. Those contributions were undoubtedly equivalent to the Nobel Prize-winning work of Granger's "co-integration method". Afterthe publications of his New Approaches to Macroeconomic Modeling and Modeling Aggregate Behavior and Fluctuations in Economics, both published by Cambridge University Press, in 1996 and 2002, respectively, his contributions rapidly became known and spread throughout the field. In short, these new works challenged econophysicists to develop evolutionary stochastic dynamics, multiple equilibria, and externalities as field effects and revolutionized the stochastic views of interacting agents. In particular, the publication of Reconstructing Macroeconomics, also by Cambridge University Press (2007), in cooperation with Hiroshi Yoshikawa, further sharpened the process of embodying ¿a perspective from statistical physics and combinatorial stochastic processes¿ in economic modeling. Interestingly, almost concurrently with Prof. Aoki¿s newest development, similar approaches were appearing. Thus, those who were working in the same context around the world at that time cametogether, exchanging their results during the past decade. In memory of Prof. Aoki, this book has been planned by authors who followed him to present the most advanced outcomes of his heritage.