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Sodium Dithionite, Rongalite and Thiurea Oxides provides an in depth overview of historical and newly developed fields of application for important sulfur-containing reductants.

In full generality, minimizing a polynomial function over a closed semi-algebraic set requires complex mathematical equations. This book explains recent developments from singularity theory and semi-algebraic geometry for studying polynomial optimization problems. Classes of generic problems are defined in a simple and elegant manner by using only the two basic (and relatively simple) notions of Newton polyhedron and non-degeneracy conditions associated with a given polynomial optimization problem. These conditions are well known in singularity theory, however, they are rarely considered within the optimization community.Explanations focus on critical points and tangencies of polynomial optimization, H├╢lderian error bounds for polynomial systems, Frank-Wolfe-type theorem for polynomial programs and well posedness in polynomial optimization. It then goes on to look at optimization for the different types of polynomials. Through this text graduate students, PhD students and researchers of mathematics will be provided with the knowledge necessary to use semi-algebraic geometry in optimization.

This book is a guide to advanced techniques used widely in applied mathematical sciences research. Chapter by chapter, readers will be led from a foundation level understanding to advanced level understanding. This is the perfect text for graduate or PhD mathematical-science students looking for support in techniques such as practical analytical methods, finite elements and symmetry methods for differential equations.Analysis and Mathematical Physics is the sixth volume of the LTCC Advanced Mathematics Series. This series is the first to provide advanced introductions to mathematical science topics to advanced students of mathematics. Edited by the three joint heads of the London Taught Course Centre for PhD Students in the Mathematical Sciences (LTCC), each book supports readers in broadening their mathematical knowledge outside of their immediate research disciplines while also covering specialized key areas.

Set within the context of growing political pluralism and the increasing use of new communication technologies for social mobilisation, the Institute of Policy Studies organised a national conference on civil society in November 2013. This collection of the essays that were presented at or inspired by the conference provides nuanced analyses of the development of the sector in Singapore since the Institute's first such conference held in 1998. The first section of the book discusses the different philosophies and approaches that underpin how civic activists engage with the State; the second section examines some key forces of change that are re-shaping the sector; and, the third section sets out some emerging issues facing it. Combining insights from experts and civic activists themselves, this book proposes an agenda for the future development of the civil society in Singapore.

We live in a world that is increasingly dependent on international trade in a context of substantial regional/national political tensions. Adding to this is an emerging understanding and concern about the social impact of biosecurity and ecosystem services risks associated with such trade. As the key international trade 'arbiter', the World Trade Organization (WTO) has never before faced such complexity within its decision-making remit.With increasing numbers of bilateral and regional agreements, as well as new developments emerging such as the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) initiated by multi-national corporations in 2018, the WTO needs to implement ways of reinforcing its legitimacy and enhancing its relevance.This book provides an original analysis of these linked developments and delivers a timely contribution to resolving environment-related international trade disputes. It provides a clear roadmap for improving WTO trade dispute resolution procedures so both biosecurity and ecosystem services risks are considered in evaluating the social, economic and environmental impacts of international trade proposals. In so doing, the WTO should deliver enhanced multilateral social welfare.

This book helps develop a better understanding of how researchers from different scientific backgrounds view models and uncertainty. It provides key steps in fostering and encouraging interdisciplinary research, which is vital in addressing several big issues that society faces today, such as climate change, longevity, financial and actuarial risk management. To make progress in these areas, researchers must develop an understanding of differing perspectives and methods of those working in other disciplines.This title presents the views and understandings of eminent people in their respective fields through interviews on the topic of modelling and uncertainty. Each expert was asked the same set of questions to help readers understand the similarities and differences existing between various disciplines. It also helps to bridge some of the gaps encountered by those carrying out inter- and multi-disciplinary research and suggests new approaches to modelling and uncertainty quantification.

In the modern world, further development of society is impossible without environmentally friendly modes of transport and their effective interaction within the framework of Smart Energy and ECO-driving concepts. Written at a time of rapid development of information technologies in various fields, this book serves as a kind of bridge for the introduction of artificial intelligence into the electric transport power supply systems.The calculation models and methods proposed make it possible to choose the most efficient modern equipment for electric power supply of electric vehicles, which, as a result, saves investment costs and reduces time to make decisions for designing complex objects. Insight is also given into building and adjusting Smart Energy class equipment to achieve optimal and economical modes.

Historically, British chemistry has been perceived as a solely male endeavour. However, this perception is untrue: the allure of chemistry has attracted British women for centuries past. Since the 1880s, women chemists have studied academic chemistry and made interesting and significant contributions to their fields, yet they have been absent from the historical record. This book rectifies the gaps, providing a well-researched glimpse into the forgotten world of British women in chemistry from 1880-1949.This title showcases the determination of these women to survive and flourish in their chosen field. The authors show how women were fascinated by chemistry long before the modern era; unravelled the complex saga of chemistry at girls' secondary schools; found the other avenues by which women chemists pursued their love of the subject; and discovered a unifying passion for chemistry and poetry that extended from grade school to university and industrial employment.

Surface photovoltage (SPV) techniques provide information about photoactive materials with respect to charge separation in space. This book aims to share experience in measuring and analyzing SPV signals and addresses researchers and developers interested in learning more about and in applying SPV methods. For this purpose, basics about processes in photoactive materials and principles of SPV measurements are combined with examples from research and development over the last two decades.SPV measurements with Kelvin probes, fixed capacitors, electron beams and photoelectrons are explained. Details are given for continuous, modulated and transient SPV spectroscopy. Simulation principles of SPV signals by random walks are introduced and applied for small systems. Application examples are selected for the characterization of silicon surfaces, gallium arsenide layers, electronic states in colloidal quantum dots, transport phenomena in metal oxides and local charge separation across photocatalytic active crystallites.

The book is about bridging the huge gaps between what engineers know, what they do and why things go wrong. It puts engineering into a wider perspective so readers can see how it relates to other disciplines - especially science and technology. Many intellectuals have dismissed engineering as 'applied science', but this book shows how wrong it is to do so - engineers apply science, but their purpose is quite different.It takes the reader on a learning journey of reflections on the gaps between theory and practice in professional life - not just in engineering but across all disciplines. The learning is summarized through 20 learning points or lessons, each one placed in context. Some of the important lessons are about learning from failure, joining-up theory and practice, understanding process, classifying uncertainty, managing risks, finding resilience, thinking systems to improve performance and nurturing practical wisdom.

Currently the field of nanocatalysis is undergoing many exciting developments and the design of silica-based organic-inorganic hybrid nanocatalysts is a key focus of the researchers working in this field.This book aims to present a succinct overview of the recent research progress directed towards the fabrication of silica-based organic-inorganic hybrid catalytic systems encompassing the key advantages of silica nanoparticles and silica-coated magnetic nanoparticles in an integrated manner. Featuring comprehensive descriptions of almost all approaches utilized for the synthesis of nanomaterials including some latest techniques such as flow and microwave-assisted synthesis that enable large-scale synthesis, it proves useful not only to academics but also industrialists. It also includes a systematic discussion on the vital characterization techniques employed for authenticating the structure of these.The title also offers an enormous amount of knowledge about the fusion of nanotechnology with green chemistry that strives to meet the scientific challenges of protecting human health and the environment.

This book brings together the state of our knowledge on the interactions between climate change and marine biota. It focusses broadly on the environmental stressors during the Anthropocene period; when human activities started to have a significant global impact on earth's geological imprint and ecosystems. This period of rapid change is accompanied by rising carbon dioxide levels, increasing global temperatures, loss of oxygen in aquatic systems, and the fast release of pollutants into the environment among many other environmental stressors originating from large scale human activities, such as widespread overfishing.The Future of Marine Life in a Changing Ocean starts by providing the reader with a brief background on fundamental concepts in ocean science and climate. It then moves on to a brief description of recent changes in marine chemistry such as ocean acidification, a decline in oxygen levels in the oceans, ocean warming, and marine pollution, with some examples of shifts in ecosystem diversity. The chapters discuss these topics in the context of how a changing ocean impacts ecosystem health, the biological carbon pump, the sequestration of carbon dioxide from the surface ocean into the deep sea, and the perceived notion of the ocean's unlimited resilience to maintain its role as a 'carbon reservoir'. Topics include threats to marine diversity, ecosystem function, latitudinal shifts in productivity and diversity, and changes in global cycling of elements such as carbon. It concludes with an analysis of the impact of climate change on food security.Written for undergraduate and graduate students, and researchers in the natural and social sciences, this book provides a science background to study environmental change in marine ecosystems as well as a science framework to study policy, marine law and the economics of climate change. This book is an essential read for anyone hoping to understand key challenges facing our oceans.

This book focuses on the new frontiers of organofluorine chemistry in synthetic, organometallic, bioorganic, medicinal, agricultural, and materials chemistry as well as chemical physics and their applications to biomedical and material sciences. The extraordinary potential of fluorine-containing molecules in biology, pharmaceuticals, agrochemical, materials and their wide range of applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of organofluorine chemistry is rapidly expanding its frontiers.Featuring major leading researchers from all over the world and their cutting-edge research projects, this title reviews the recent advances and envision the new exciting developments in the future. Frontiers of Organofluorine Chemistry is an excellent reference book for professional researchers, and graduate students, in both industry and academia to get inspirations and new ideas for their projects.

From the lens of holistic systems theory, this book discusses strategic management adapted to evolving convergence in an era of advanced ICT from the viewpoint of the major management elements of strategy, organizations, technologies, operations and leadership.To discuss corporate change in response to such advanced technology in a theoretical and empirical manner, it is necessary not only to analyze and consider individual management elements such as strategy, organizations, technologies, operations and leadership in a piece-meal manner but also to determine the research issues from a framework based on a holistic management perspective through systems theory including interaction between and among the respective individual management elements (from micro to macro elements).Applying both innovation theory and capabilities theory, this book presents a new framework and knowledge for holistic strategic management from a systems theory lens that focuses on the issue of how major corporations can develop capabilities to achieve strategic innovation in response to the impacts of advanced ICT on corporate management.

Indole derivatives are the most common heterocycle compounds present in nature, for this reason, they have been referred to as "privileged structures". In fact, many approved drugs - and natural products - belong to this family. Among indole derivatives, oxindoles have a structural complexity, which have stimulated generations of synthetic chemists to design strategies for assembling these structures, and their enantioselective synthesis is still growing.This book proposes to describe the known enantioselective syntheses of oxindole derivatives. It is divided in six chapters each referring to a specific class of asymmetric oxindole derivatives. After the introduction, Chapter 2 describes all-carbon spirooxindoles; Chapter 3, open chain 3,3-dialkyloxindoles; Chapter 4, 3-substituted-3-aminooxindoles; Chapter 5, 3-substituted-3-hydroxyoxindoles; Chapter 6, 3-hetero-3-substituted oxindoles. It will be a useful tool for synthetic chemists, who assemble total synthesis of natural products, as well as for drug discovery chemists either in academic or in industry R&S laboratories.

Rethinking Evolution links Darwin's early insights to the molecular realm inside living cells. This updated evolutionary synthesis provides an accessible explanation for biological complexity that cuts through the confusion surrounding evolutionary theory in a practical way.In addition to a wide-ranging survey of proposed updates to the modern synthesis, this title provides extraordinary new insights including emergent evolutionary potential and the generative phenotype. Drawing on well-characterized empirical facts, Rethinking Evolution transcends classical Darwinian natural selection while retaining those core principles that have stood the test of time.The updated synthesis brings a broad spectrum of specialized research together to provide a more plausible naturalistic explanation for biological evolution than ever before. Perspectives ranging from the role of energy in the origin of life to the networks of protein-DNA interactions that govern multicellular development are woven together in a robust conceptual fabric consistent with 21st century cutting-edge research.Inspired in part by the surprising ways that DNA sequences change - such as his early discovery of a fundamental mispairing mechanism by which DNA sequences expand - and drawing on a career's worth of experience both as a research scientist as well as a biology and chemistry tutor - the author provides an engaging account that is essential reading - both for the public awareness and understanding of the science of evolution and for students and professionals in the biomedical sciences.

This title introduces the theory of arc schemes in algebraic geometry and singularity theory, with special emphasis on recent developments around the Nash problem for surfaces. The main challenges are to understand the global and local structure of arc schemes, and how they relate to the nature of the singularities on the variety. Since the arc scheme is an infinite dimensional object, new tools need to be developed to give a precise meaning to the notion of a singular point of the arc scheme.Other related topics are also explored, including motivic integration and dual intersection complexes of resolutions of singularities. Written by leading international experts, it offers a broad overview of different applications of arc schemes in algebraic geometry, singularity theory and representation theory.

This work presents a comprehensive theory describing atomic diffusion in silicon crystals under strong nonequilibrium conditions caused by ion implantation and interaction with the surface or other interfaces. A set of generalized equations that describe diffusion of impurity atoms and point defects are presented in a form suitable for solving numerically. Based on this theory, partial diffusion models are constructed, and the simulation of many doping processes used in microelectronics is carried out.Coupled Diffusion of Impurity Atoms and Point Defects in Silicon Crystals is a useful text for researchers, engineers, and advanced students in semiconductor physics, microelectronics, and nanoelectronics. It helps readers acquire a deep understanding of the physics of diffusion and demonstrates the practical application of the theoretical ideas formulated to find cheaper solutions in the course of manufacturing semiconductor devices and integrated microcircuits.

A unique title comparing rural policies and employment in the two most developed parts of the world — the EU and USA. While both regions are concerned for their vast rural areas, each adopts a strikingly different approach to create and maintain employment there, making rural space attractive to businesses and residents.This book focuses on a major issue of socioeconomic and policy concern, i.e. whether jobs and incomes can be protected or created in rural areas, where often agriculture no longer provides a large and secure basis for employment. Within a "paired" chapter structure covering both the European Union and the United States of America, it deals with several themes of interest including farm policies, labor entry and exit, and rural and household enterprise diversification. Specific "special studies" also analyze recent developments within countries or regions.

This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

Managing Innovation is a three-part series covering contemporary technology and innovation management research areas. Each volume comprises key articles from both the International Journal of Innovation Management and the International Journal of Innovation and Technology Management, published by World Scientific, and provides an international, disciplinary approach across its broad coverage of topics.Relevant for both academics and practitioners, this volume focuses on key aspects of crowd innovation including motivations, challenges and benefits of this approach.