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Focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. This book includes review chapters on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), and theory of protein-protein binding.

Delves into one of the greatest riddles perplexing modern science: Why are humans so smart? This title investigates the origins of human intelligence, starting with classical Darwinian concepts. It concludes with a speculative epigenetic theory of intelligence that does not require DNA mutations as a source of evolution.

Contains papers presented at the 19th International Conference on Genome Informatics (GIW 2008) held at the Marriott Surfers Paradise Resort, Gold Coast, Queensland, Australia from December 1 to 3, 2008. This title includes a total of 18 contributed papers that were selected for the presentation at GIW 2008.

Design for prevention or remediation of indoor air pollution requires expertise in optimizing geometrical configurations; knowledge of HVAC systems, perceived or expected contaminants and source locations; and economics. This title describes a series of numerical models that run in MATLAB.

Contains papers based on the presentations at the 8th Annual International Workshop on Bioinformatics and Systems Biology held at the Teikyo Hotel, Berlin, from June 9 to June 10, 2008. This workshop started in 2001 as an event for doctoral students to present and discuss their research results and approaches in bioinformatics and systems biology.

Entropy is a measure of order and disorder. If left alone, aging systems go spontaneously from a youthful, low entropy and order, to an old, high entropy and disorder. This book presents the commonality of entropy principles which govern the birth, maturation, and senescent history of aging humans, corporations, and the universe.

Presents an original approach to the history of the field of computer science. This title covers various aspects of computer science, going from the theory of computation, the theory of programming, and the theory of computer system performance, all the way to computer hardware and to major numerical applications of computers.

Traces through the formation of matter, of stars and planets, the Earth itself, and then through to the beginnings of life and the evolution of man. This book does not solve the mysteries of what initiated the Big Bang or how life evolved from inanimate matter, but it does make clear the nature of those problems.

The year 2007 marked not only the centenary of Imperial College London but also the 50th anniversary of the late Nobel Laureate Professor Abdus Salam's arrival at the College. Accordingly, a conference entitled "Salam + 50" organized by the Theoretical Physics Group was held at Imperial College on 7 July 2007.

Investigates the origins and implications of securitization crisis. This book offers an integrated series of case studies drawn from the United States, the United Kingdom and Australia. It charts what went wrong within the investment houses and why the regulatory systems failed.

Presents practical tools for managers to utilize so that they are better prepared for innovation with external actors and accordingly they can successfully implement open and networked innovation in their business.

Highlights the variety of opportunities that firms may have in the innovation and new business development with external actors. This book shows readers that firms can interact, innovate, and make business with different actors, both formally and informally, and use different levels of openness within inter-organizational innovation processes.

Taking the discovery of the electron, the formulation of Maxwellian electromagnetism and Einstein's elucidation of Brownian motion as its starting point, this title provides a comprehensive presentation of the three seminal ideas of 20th century physics: Special and General Relativity, Quantum Theory and the Nuclear Atom.

The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Project came into being, the people who created it, and the cadre of scientists who are attempting to see the promise of the Project realized.

Provides a comprehensive overview of fracture mechanics of conservative and dissipative materials, as well as a general formulation of nonlinear field theory of fracture mechanics and a rigorous treatment of dynamic crack problems involving coupled magnetic, electric, thermal and mechanical field quantities.

Concentrates on how to construct a Markov process by starting with a suitable pseudo-differential operator. Feller processes, Hunt processes associated with Lp-sub-Markovian semigroups and processes constructed by using the Martingale problem are at the center of the considerations.

Fully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. Correct interpretation of the data from such trials depends largely on adequate design and on performing the appropriate statistical analyses. This book provides a useful guide to medical statisticians and others faced with the often difficult problems of designing and analysing clinical trials.

This is the second volume on pseudo-differential operators and Markov processes. In this text two topics are discussed: the construction of Feller and Lp-sub-Markovian semigroups by starting with a pseudo-differential operator; and the potential theory of these semigroups and their generators.

A practical guide to the analysis of materials, including a description of the underlying theories and instrumental aberrations caused by real experiments. The main emphasis concerns the analysis of thin films and multilayers, primarily semiconductors, although the techniques are very general.

Shows how various optimization techniques are used in the novel anti-optimization technique, and how the structural optimization can be exponentially enhanced by incorporating the concept of worst-case scenario, thereby increasing the safety of the structures designed in various fields of engineering.

Provides an in-depth treatment of the study of the stability of engineering structures. This book is useful for professional engineers, graduate students and researchers interested in structural stability.

Addresses public health issues in traditional, complementary and alternative medicine (TCAM). This book presents reviews of TCAM research in a range of priority public health areas such as malaria and HIV. It offers a global overview of policy and legislative trends in this field.

Introduction to Engineering; History of Engineering; Contemporary Context of Engineering

Outlines the developments and research directions being made world-wide in earth sciences. This book explains how methodologies such as satellite remote sensing and supercomputing simulations are changing research in earth sciences; how the earth system is being viewed in a holistic way, linking the atmosphere, ocean and solid earth; and more.

Suitable for researchers and graduate students working in the field of nonlinear spectroscopy, this book represents the comprehensive treatment of high-order harmonic generation in laser-produced plumes, covering the principles, past and present experimental status and important applications.

Suitable for honours and BSc students majoring in physical chemistry, this book emphasizes on applications of thermodynamics to liquids and solids as well as gases. It also helps students learn that thermodynamics can be applied to systems which are not in equilibrium.

Sets out the paradoxical position of biomedical science finds itself in, in the early 21st century. This title deals with the creative nature of original science, how it is driven by curiosity and self-motivation and how these can be stifled by pettifogging managerialism.

The three greatest scientific mysteries, as yet poorly understood, are the origin of the universe, the origin of life and the development of consciousness. This book follows a narrow scientific pathway from the Big Bang to mankind, and depicts the causal relationship between each step and the next. It deals with many important areas of science.

Focuses on equity derivatives and charts and how key assumptions on the dynamics of stocks impact on the value of exotics. This title focuses on intuition and practical application.

Provides an important step in introducing principles and concepts within the field of toxicology. This edition highlights the underlying mechanisms of toxicity through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.