mTOR Inhibitors and Epilepsy Comorbidities

This book provides an in-depth exploration of the role of mTOR inhibitors in the management of epilepsy and its comorbidities. The book covers the basic pharmacology of mTOR inhibitors and their effects on signaling pathways that regulate neuronal excitability, synaptic plasticity, and gene expression. It also discusses the clinical trials and biomarkers used to assess the efficacy and safety of mTOR inhibitors in epilepsy treatment. The book delves into the neuropathology of epilepsy, including neuroprotection, neuroinflammation, neurodegeneration, and epileptogenesis, and how mTOR inhibitors can modulate these processes. Additionally, the book covers the impact of mTOR inhibitors on neuronal homeostasis, neurotrophic factors, mitochondrial dysfunction, autophagy, oxidative stress, and neuroimaging. The book further explores the potential of personalized medicine and precision therapy in epilepsy treatment by considering cognitive dysfunction, mood disorders, sleep disorders, social functioning, quality of life, and patient-reported outcomes. Psychosocial interventions, animal models, translational research, neuropharmacology, network analysis, gene therapy, stem cells, neuroengineering, neurotechnology, precision diagnostics, and regulatory issues are also discussed in detail. Overall, the book provides a comprehensive guide for researchers and clinicians to better understand the potential benefits and limitations of mTOR inhibitors in epilepsy treatment, and offers insights into how precision medicine approaches can improve outcomes for patients with epilepsy and comorbidities.